DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG31729 and ATP10D

DIOPT Version :9

Sequence 1:	NP_609634.1	Gene:	CG31729 / 34736	FlyBaseID:	FBgn0051729	Length:	1256	Species:	Drosophila melanogaster
Sequence 2:	NP_065186.3	Gene:	ATP10D / 57205	HGNCID:	13549	Length:	1426	Species:	Homo sapiens

Alignment Length:	1335	Identity:	374/1335 - (28%)
Similarity:	584/1335 - (43%)	Gaps:	316/1335 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   200 LCSCWRKWFRPRELRAR------TVNLGRVNTEKFP----PNEIRNQKYNFITFLPLVLFEQFRF 254
            |.:|.||..:..:|..|      .:...:...|||.    .|.||..||..:.|:|..|||||..
Human    33 LLACGRKSSQTPKLSGRHRIVVPHIQPFKDEYEKFSGAYVNNRIRTTKYTLLNFVPRNLFEQFHR 97

  Fly   255 FLNLYFLLMALSQFIPDIRIGYPYTYWGPLGFVLMVTICREAVDDLRRHQRDHEVN---SQKYKR 316
            ..|||||.:.:..::|.:..........||..||.:...::.::|.|:::.|.::|   ::.|.|
Human    98 AANLYFLFLVVLNWVPLVEAFQKEITMLPLVVVLTIIAIKDGLEDYRKYKIDKQINNLITKVYSR 162

  Fly   317 LSSTNISGYEMVPSSKLKVGDVIIVEKNERVPADLILLRTSDRSGSVFVRTDQLDGETDWKPRLA 381
            .....|...    ...:.|||.|.:..||.:|||::||.::|..|...:.|..||||::.|.|..
Human   163 KEKKYIDRC----WKDVTVGDFIRLSCNEVIPADMVLLFSTDPDGICHIETSGLDGESNLKQRQV 223

  Fly   382 V-PYTQKLSRDSEL--HSIDASFYVEKPQNDIHSFIATFCMADGSEDTGLSVENTLWAN-TVVAA 442
            | .|.:   :|||:  ....:....|.|.||:..| ..|......|..|||.||.|... |:...
Human   224 VRGYAE---QDSEVDPEKFSSRIECESPNNDLSRF-RGFLEHSNKERVGLSKENLLLRGCTIRNT 284

  Fly   443 GTATGIVIYTGCETRSVMNNSQPRSKVGLLDMEINGLTKVLFCAVLGLSLVMMMLKGF--GGPWY 505
            ....|||:|.|.||::::|||.||.|...|:...|  |.||:|.:|   ||:|.|.|.  .|.|.
Human   285 EAVVGIVVYAGHETKAMLNNSGPRYKRSKLERRAN--TDVLWCVML---LVIMCLTGAVGHGIWL 344

  Fly   506 R-------------------------YMF-RFVLLFSYIIPISLRVNLDMGKA-----------F 533
            .                         ||| ..::|...:|||||.|::::.|.           |
Human   345 SRYEKMHFFNVPEPDGHIISPLLAGFYMFWTMIILLQVLIPISLYVSIEIVKLGQIYFIQSDVDF 409

  Fly   534 YSWQMQNDSNIQGTVVRSTTIPEELGRISYVLTDKTGTLTQNEMVFKKIHLG------------- 585
            |:.:|  ||.:|   .|:..|.|:||:|.|:.:|||||||:|:|||::..:.
Human   410 YNEKM--DSIVQ---CRALNIAEDLGQIQYLFSDKTGTLTENKMVFRRCSVAGFDYCHEENARRL 469

  Fly   586 -----IVSHDAD---------------------TFHHIGQMIQKLSGNILQQQQGSLSSSSSG-G 623
                 .||.|.|                     |.|: |.:..|.|.::    .||..:..|| |
Human   470 ESYQEAVSEDEDFIDTVSGSLSNMAKPRAPSCRTVHN-GPLGNKPSNHL----AGSSFTLGSGEG 529

  Fly   624 DSTKP---------------------------------MMFGNRMRRP--EGWREWEAVRALALC 653
            .|..|                                 |.....::.|  |.....:...|||:|
Human   530 ASEVPHSRQAAFSSPIETDVVPDTRLLDKFSQITPRLFMPLDETIQNPPMETLYIIDFFIALAIC 594

  Fly   654 HNVT-------------------PVSDDEDNRSV--------STASTVTGGNN------------ 679
            :.|.                   |:...|:.:|:        |::.::..|..
Human   595 NTVVVSAPNQPRQKIRHPSLGGLPIKSLEEIKSLFQRWSVRRSSSPSLNSGKEPSSGVPNAFVSR 659

  Fly   680 ----------SPTKSVIN--IEAPG-------STDTEHQ------------------------YQ 701
                      ||.:..::  .|:|.       .|:||.|                        |:
Human   660 LPLFSRMKPASPVEEEVSQVCESPQCSSSSACCTETEKQHGDAGLLNGKAESLPGQPLACNLCYE 724

  Fly   702 AASPDEIALVKWTEQVGLTLIARDLNTMTLQVKTPSE---DNDIL--LHYQILQLFPFTSESKRM 761
            |.||||.|||          .|......||:.:||.:   |...|  |.:|:|.:.||.|..|||
Human   725 AESPDEAALV----------YAARAYQCTLRSRTPEQVMVDFAALGPLTFQLLHILPFDSVRKRM 779

  Fly   762 GIIVRESKTGQITFYLKGADVVMSSI--VQYNDWLSEESGNM-------------AREGLRTLVV 811
            .::||...:.|:..|.||||.|:..:  |...|..|.|...|             |::|||||.:
Human   780 SVVVRHPLSNQVVVYTKGADSVIMELLSVASPDGASLEKQQMIVREKTQKHLDDYAKQGLRTLCI 844

  Fly   812 AKKVLTEEQYSDFETRYNAARLSITDRVAKVAAVTESLERELELLCLTGVEDRLQENVRPTLELL 876
            ||||:::.:|:::...:..|..||.:|...:......||.:|.||..||:||||||.|..::|.|
Human   845 AKKVMSDTEYAEWLRNHFLAETSIDNREELLLESAMRLENKLTLLGATGIEDRLQEGVPESIEAL 909

  Fly   877 RNAGVRVWMLTGDKLETACCIAKSSQLIGRNQGLH----------------VLRSVKTRTDAHQE 925
            ..||:::|||||||.|||..||.:.:|:..:..|.                :|:.::.:|.|..|
Human   910 HKAGIKIWMLTGDKQETAVNIAYACKLLEPDDKLFILNTQSKDACGMLMSTILKELQKKTQALPE 974

  Fly   926 LNSFR---------RKQG--HALVISGESLEVCLQ-YYRPEFLELATASPAVVCCRCSPTQKAQV 978
            ..|..         |..|  ..|:|:|::||..|| ..:.:||||.:...||||||.:|.||::|
Human   975 QVSLSEDLLQPPVPRDSGLRAGLIITGKTLEFALQESLQKQFLELTSWCQAVVCCRATPLQKSEV 1039

  Fly   979 VALIQKHTGKRTCAVGDGGNDVSMIQQADAGVGIEGREGRQASLAGDFSIPQFSHIAKLLLIHGR 1043
            |.|::.|....|.|:|||.|||||||.||.|:|:.|:||.||.:|.||::.||.|::||||:||.
Human  1040 VKLVRSHLQVMTLAIGDGANDVSMIQVADIGIGVSGQEGMQAVMASDFAVSQFKHLSKLLLVHGH 1104

  Fly  1044 RSYKRSAALSQFVIHRGLIITTLQAVFSAVFYLSSVALYQGFLMVGYSTLYTMF-PVFSLVLDQD 1107
            ..|.|.:.:..:..::.:....|...:......|..::...::::.::.|:|.. ||...||::|
Human  1105 WCYTRLSNMILYFFYKNVAYVNLLFWYQFFCGFSGTSMTDYWVLIFFNLLFTSAPPVIYGVLEKD 1169

  Fly  1108 ITSETAVTYPELYKDLSKGRSLSYKTFFIWVLISIYQGGVIMYGALILF----VDEFIHIVAISF 1168
            :::||.:..||||:...|..:....||:|.:|.:.||..|..:.....:    .|.|.....::.
Human  1170 VSAETLMQLPELYRSGQKSEAYLPHTFWITLLDAFYQSLVCFFVPYFTYQGSDTDIFAFGNPLNT 1234

  Fly  1169 SAL--IMTELIMVALTVRTW-HRLMVLAELFSLALYLISLAVL--------HEYFDW---EFIWS 1219
            :||  ::..|::.:.:: || |.|:::..:.|..|:.|....:        :.|  |   |.:..
Human  1235 AALFIVLLHLVIESKSL-TWIHLLVIIGSILSYFLFAIVFGAMCVTCNPPSNPY--WIMQEHMLD 1296

  Fly  1220 YDFLWKVSLITLVSCLPLYIIKFLRKKCSPPSYLK 1254
            ..|.....|.|.::.||.::.:.|:....|...|:
Human  1297 PVFYLVCILTTSIALLPRFVYRVLQGSLFPSPILR 1331

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31729	NP_609634.1	PhoLip_ATPase_N	227..279	CDD:292826	20/55 (36%)
		ATPase-Plipid	228..1252	CDD:273734	365/1297 (28%)
		E1-E2_ATPase	323..525	CDD:278548	75/233 (32%)
		Cation_ATPase	<704..783	CDD:289987	31/83 (37%)
		HAD_like	<975..1019	CDD:304363	24/43 (56%)
		PhoLip_ATPase_C	1021..1249	CDD:292829	58/246 (24%)
ATP10D	NP_065186.3	ATPase-Plipid	71..1327	CDD:273734	363/1291 (28%)
		PhoLip_ATPase_N	<71..122	CDD:292826	18/50 (36%)
		E1-E2_ATPase	128..>216	CDD:278548	26/91 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	506..531		8/29 (28%)
		Cation_ATPase	<727..807	CDD:289987	32/89 (36%)
		HAD_like	<1051..1082	CDD:304363	20/30 (67%)
		PhoLip_ATPase_C	1082..1327	CDD:292829	58/247 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165144898
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53737
OrthoDB	1	1.010	-	-		D587717at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.860