DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG31729 and atp8b3

DIOPT Version :9

Sequence 1:	NP_609634.1	Gene:	CG31729 / 34736	FlyBaseID:	FBgn0051729	Length:	1256	Species:	Drosophila melanogaster
Sequence 2:	XP_003201102.2	Gene:	atp8b3 / 566530	ZFINID:	ZDB-GENE-050208-424	Length:	1174	Species:	Danio rerio

Alignment Length:	1186	Identity:	346/1186 - (29%)
Similarity:	561/1186 - (47%)	Gaps:	204/1186 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   163 THSTTVIDPENG-------SSTVFYQHNRRKSKSRSIGNVCKLCLCSCWRKWFRPRELRARTVNL 220
            |.|||    |||       :...|:|..||:|           .||..|
Zfish    22 TGSTT----ENGIKWEVRANGRDFHQSCRRRS-----------VLCIRW---------------- 55

  Fly   221 GRVNTEKFPPNEIRNQKYNFITFLPLVLFEQFRFFLNLYFLLMALSQFIPDIRIGYPYTYWGPLG 285
            ||     :..|.:|:.||..:||.||.|:|||:...||:|||:.:.|.:|.|.....||...||.
Zfish    56 GR-----YADNVVRSYKYTPLTFFPLNLYEQFQRAANLFFLLIVILQCVPVIATIPWYTTMLPLL 115

  Fly   286 FVLMVTICREAVDDLRRHQRDHEVNSQKYKRLSSTNISGYEMVPSSKLKVGDVIIVEKNERVPAD 350
            .||.|..|::...|:.|.:.|.::|.:....|:.   .|::.|....:.|||::.|.|::.:|||
Zfish   116 IVLFVRGCKDLATDVGRRRSDAQINRRPCDILTP---EGFKTVKWKDVCVGDILRVHKDQVIPAD 177

  Fly   351 LILLRTSDRSGSVFVRTDQLDGETDWKPRLAVPYTQ-KLSRDS---ELHSIDASFYVEKPQNDIH 411
            |:||.:::.....:|.|..:||||:.|.|.|:..|. :|:.||   .|.:.||....|:|..::|
Zfish   178 LLLLCSTEPYSLCYVETADIDGETNLKFRQALTVTHTELNGDSTEQNLAAFDAIVRCEEPNGNLH 242

  Fly   412 SFIATFCMADGSEDTGLSVENTLWANTVVA-AGTATGIVIYTGCETRSVMNNSQPRSKVGLLDME 475
            ||...|...  .|...|..::.|...||:. ...|.|:.||||.:::.:.|..:.:.|...:::.
Zfish   243 SFRGEFHWK--GERHLLGTDHLLLRGTVLRNTDYAYGLTIYTGSDSKILQNCGRLKLKKTHVEIL 305

  Fly   476 INGLTKVLFCAVLGLSLVMMMLKGF------------------GGPWYRYMFRF---VLLFSYII 519
            :|....|:...:|..:|::.:..|.                  ..|.|:....|   ::|.|..:
Zfish   306 LNKTVLVILLFMLTTALLLAIGAGIFEYRISPNYDVVSIVQRDSSPAYQGFLTFWGYIILLSPSM 370

  Fly   520 PISLRVNLDMGKAFY----SWQMQ---NDSNIQGTVVRSTTIPEELGRISYVLTDKTGTLTQNEM 577
            |:||.:..::....:    .|.::   .|:|.... .|:||:.||||::.::|:|||||||||.:
Zfish   371 PMSLYITFEVIHMVHCLLIGWDVEMYWEDTNCPAH-ARTTTLNEELGQVGHLLSDKTGTLTQNRL 434

  Fly   578 VFKKIHLGIVSHDADTFHHIGQMIQKLSGNILQQQQG---SLSSSSSGGDSTKPMMFGNRMRRPE 639
            :|::..  |..|              :.|:|.|:.:.   |.:..|.||.........:::|...
Zfish   435 LFRQCF--IAGH--------------IYGDISQKSKPLDLSWNRFSCGGLKFSDQRLVDKLRGRG 483

  Fly   640 GWREWEAVRALALCHNVTPVSDDEDNRSVSTASTVTGGNNSPTKSVINIEAPGSTDTEHQYQAAS 704
            .....|...||||||.|  :|:.:|...                               .|||||
Zfish   484 SLECQEFFTALALCHTV--MSEWKDGLP-------------------------------HYQAAS 515

  Fly   705 PDEIALVKWTEQVGLTLIARDLNTMTLQVKTPSEDNDILLHYQILQLFPFTSESKRMGIIVRESK 769
            |||.|||....::|...::|..:|:|:      .:..:..:||:|.|..|||:.:||.::|| |.
Zfish   516 PDEEALVCAARELGWVFLSRTRDTLTI------SEMGLTRNYQLLALLDFTSKRRRMSVLVR-SP 573

  Fly   770 TGQITFYLKGADVVMSSIVQYNDWLSEESGNMARE-----GLRTLVVAKKVLTEEQYSDFETRYN 829
            .||:..|.||||:|:...:| .||..:||.:.|.|     .||||.||.:.:.|..::::....|
Zfish   574 GGQLKLYSKGADIVILERLQ-KDWPLQESTDRALELFAQSCLRTLCVAVRPVPEALWTEWSRALN 637

  Fly   830 AARLSITDRVAKVAAVTESLERELELLCLTGVEDRLQENVRPTLELLRNAGVRVWMLTGDKLETA 894
            .|..:..::...:..:.:.:|::|.||.:|.:||||||.|..|:..||.|||:||:|||||.|||
Zfish   638 LAGTATGNQETLLEEIYDQMEKDLMLLGVTAIEDRLQEGVPETIASLRRAGVKVWVLTGDKTETA 702

  Fly   895 CCIAKSSQLIGRNQGL-------HVLRSVKTRTDAHQ--------ELNSFRRKQGHALVISGESL 944
            ..:..:.:|:..:..|       .:|.|..:..|...        :..:...|.  ||||||..|
Zfish   703 VNVGYACKLMDPDTTLIQGEELRQLLESPSSNVDVKSKEPEVWITDKKAVMSKA--ALVISGPEL 765

  Fly   945 EVCLQ--YYRPEFLELATASPAVVCCRCSPTQKAQVVALIQKHTGKRTCAVGDGGNDVSMIQQAD 1007
            ....:  .:..:|:.|:....:|:|||.:|.|||:||.:::||:...|.|:|||.|||:||:.|.
Zfish   766 AELTKSSEWGAKFVALSGQCQSVLCCRVTPAQKAEVVEMVRKHSASITMAIGDGANDVNMIKTAH 830

  Fly  1008 AGVGIEGREGRQASLAGDFSIPQFSHIAKLLLIHGRRSYKRSAALSQFVIHRGLIITTLQAVFSA 1072
            .|||:.|.||.||.|..||::.|||.:.||||:||..||.|.:.|.::.:::......:...:|
Zfish   831 IGVGLCGVEGSQAVLNADFALAQFSFLRKLLLVHGHWSYYRISILLRYFLYKTTAFALVHTWYS- 894

  Fly  1073 VFY--LSSVALYQGFLMVGYSTLYTMFPV-FSLVLDQDITSETAVTYPELYKDLSKGRSLSYKTF 1134
             ||  .|:..:|:.:.:..::|.||..|: .:.:.:|||::.:.:.:||:|....|.:..:....
Zfish   895 -FYNGFSAQPMYESWYISLFTTTYTSLPIQCTGIFEQDISARSCLCWPEIYSIGQKKQLFNPSVL 958

  Fly  1135 FIWVLISIYQG--------GVIMYGALILFVDEFIHIVAISFSALIMTELIMVALTVRTWHRLMV 1191
            ...:|.|.|..        |::.|.||    |.....:.|..|.|..|.| .|.|..:.|.:..|
Zfish   959 ASTLLYSFYSSIIFFFVPMGILQYSAL----DFQTLAITIETSVLFATTL-EVILCTKYWTKWNV 1018

  Fly  1192 LAELFSLALYLISLAVLH----------EYFDWEFI------WSYDFLW-KVSLITLVSCLPLYI 1239
            .|.:||||.:.:|...||          :||   |:      :|...:| .:.:.|.|:.||...
Zfish  1019 AAVIFSLAAFFLSTLALHSTRLFTASPKDYF---FLGASQNAYSTPEVWLTIFVTTCVAVLPSIT 1080

  Fly  1240 IKFLRKKCSPPSYLKL 1255
            .:.|....:.|:..|:
Zfish  1081 TRALGVVLANPNKHKI 1096

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31729	NP_609634.1	PhoLip_ATPase_N	227..279	CDD:292826	20/51 (39%)
		ATPase-Plipid	228..1252	CDD:273734	328/1109 (30%)
		E1-E2_ATPase	323..525	CDD:278548	61/227 (27%)
		Cation_ATPase	<704..783	CDD:289987	30/78 (38%)
		HAD_like	<975..1019	CDD:304363	23/43 (53%)
		PhoLip_ATPase_C	1021..1249	CDD:292829	67/255 (26%)
atp8b3	XP_003201102.2	PhoLip_ATPase_N	52..109	CDD:292826	24/77 (31%)
		ATPase-Plipid	58..1096	CDD:273734	328/1112 (29%)
		Cation_ATPase	<515..591	CDD:289987	31/82 (38%)
		R3H	650..706	CDD:294210	28/55 (51%)
		HAD_like	<813..837	CDD:304363	14/23 (61%)
		PhoLip_ATPase_C	844..1084	CDD:292829	66/249 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170578130
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53737
OrthoDB	1	1.010	-	-		D587717at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	4.860