DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG31729 and atp8b5b

DIOPT Version :9

Sequence 1:	NP_609634.1	Gene:	CG31729 / 34736	FlyBaseID:	FBgn0051729	Length:	1256	Species:	Drosophila melanogaster
Sequence 2:	XP_691903.2	Gene:	atp8b5b / 563450	ZFINID:	ZDB-GENE-120502-1	Length:	1189	Species:	Danio rerio

Alignment Length:	1196	Identity:	337/1196 - (28%)
Similarity:	537/1196 - (44%)	Gaps:	255/1196 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   211 RELRA--RTVNLGRVNTEKFPPNEIRNQKYNFITFLPLVLFEQFRFFLNLYFLLMALSQFIPDIR 273
            |.|||  |..||    :.|:..|.|:..|||..|||||.|||||:...|.||:.:.:.|.||.|.
Zfish    21 RRLRANDREFNL----SFKYANNAIKTSKYNVFTFLPLNLFEQFQRLANAYFVFLLILQLIPQIS 81

  Fly   274 IGYPYTYWGPLGFVLMVTICREAVDDLRRHQRDHEVNSQKYKRLSSTNISGYEMVPSSKLKVGDV 338
            ....:|...||..||.:|:.::..||:.||:.|.:||::|.:.|....:.....:   .::|||:
Zfish    82 SLSWFTTVVPLLLVLSITLAKDLSDDITRHKNDKQVNNRKVEVLIDGELKTERWM---NVQVGDI 143

  Fly   339 IIVEKNERVPADLILLRTSDRSGSVFVRTDQLDGETDWKPRLAVPYTQKLSRD-SELHSIDASFY 402
            :.:|.||.|.|||:||.:|:....:::.|.:|||||:.|.:.|:..|.:|..| ..|.:......
Zfish   144 VKLENNEFVTADLLLLSSSEPLNLIYIETAELDGETNLKVKQALTLTGELCNDIQRLAAFKGEVR 208

  Fly   403 VEKPQNDIHSFIATFCMADGSED----------TGLSVENTLWANTVVAAGTATGIVIYTGCETR 457
            .|.|.|.:..|..|..:  |.|.          .|.::.||.|         ..|:|::.|.:|:
Zfish   209 CEPPNNRLDKFTGTLVV--GGETFALDNERILLRGCTLRNTEW---------CFGLVLFGGPDTK 262

  Fly   458 SVMNNSQPRSKVGLLDMEINGLTKVLF------CAVL-----------GLSLVMMMLKGFGG--- 502
            .:.|:.:...|...:|..:|.|...:|      |.:|           |.|.::.:.:..|.
Zfish   263 LMQNSGKSIFKRTSIDHLMNVLVLFIFGFLAFMCTILSIGNAIWEYQEGNSFIVFLPRADGANAS 327

  Fly   503 -PWYRYMFRFVLLFSYIIPISLRVNLD---MGKAFY-SW-----QMQNDSNIQGTVVRSTTIPEE 557
             ..:...:.:|::.:.::||||.|:::   :|.::: .|     .:::|:..|   .|:||:.||
Zfish   328 LSAFLTFWSYVIILNTVVPISLYVSVEILRLGNSYFIDWDRKMYHVKSDTPAQ---ARTTTLNEE 389

  Fly   558 LGRISYVLTDKTGTLTQNEMVFKKIHLGIVSHDADTFHHIGQMIQ--------KLSGNILQQQQG 614
            ||:|.|:.:|||||||||.|.|.:..:...|: .:.....||.::        ..|.|:|
Zfish   390 LGQIKYIFSDKTGTLTQNIMTFNRCSINGKSY-GEVVDFAGQRVEVTEKTEKVDFSWNLL----- 448

  Fly   615 SLSSSSSGGDSTKPMMFGNRMRRPE----GWREWEA-VRALALCHNVTPVSDDEDNRSVSTASTV 674
                       ..|..|.:..:..|    |..|..| .|.|||||.|.|..
Zfish   449 -----------ADPKFFFHDHKLVEAVKLGSPEVHAFFRLLALCHTVMPEE-------------- 488

  Fly   675 TGGNNSPTKSVINIEAPGSTDTEHQYQAASPDEIALVKWTEQVGLTLIARDLNTMTLQVKTPSED 739
                              .|..:..|||.||||.|||......|....||...|:::      .:
Zfish   489 ------------------KTQGDLFYQAQSPDEGALVTAARNFGFVFRARTPETISV------VE 529

  Fly   740 NDILLHYQILQLFPFTSESKRMGIIVRESKTGQITFYLKGADVVM--------SSIVQYNDWLSE 796
            ..|...|::|.:..|.:..|||.:|||..: |::..|.||||.::        |.:::..   :|
Zfish   530 MGIETTYELLAVLDFNNVRKRMSVIVRNPE-GKLMLYCKGADTIIYERLHPSCSKVMEVT---TE 590

  Fly   797 ESGNMAREGLRTLVVAKKVLTEEQYSDFETRYNAARLSITDRVAKVAAVTESLERELELLCLTGV 861
            .....|.||||||.:|.|.|.|::::::..|::.|.:::.||..|:.|:.|.:|::|.|:..:.|
Zfish   591 HLNEYAGEGLRTLALAYKDLDEDKFAEWRRRHHEASIALEDREEKLDAIYEEIEKDLILIGASAV 655

  Fly   862 EDRLQENVRPTLELLRNAGVRVWMLTGDKLETACCIAKSSQLIGRNQGLHVLRSVKTRTDAHQEL 926
            ||:||:.|..|:|.|..|.:::|:|||||.|||..|..|..::........:.:..|..:..:||
Zfish   656 EDKLQDGVPQTIEQLAKADIKIWVLTGDKQETAENIGYSCNMLREEMTEIFIVAANTAEEVREEL 720

  Fly   927 NSFRRKQG------------------------------HALVISGESLEVCLQY-YRPEFLELAT 960
            .:.|:|..                              :.|||:|.||...||. .:.|.|..|.
Zfish   721 VNARKKMSPESGDEPPMEKSRFLGKKSQVVEDEKVDGEYGLVINGHSLAFALQKDMQVELLRTAC 785

  Fly   961 ASPAVVCCRCSPTQKAQVVALIQKHTGKRTCAVGDGGNDVSMIQQADAGVGIEGREGRQASLAGD 1025
            ....|:|||.:|.||||||.|::||....|.|:|||.||||||:.|..||||.|:||.||.|:.|
Zfish   786 MCQTVICCRVTPLQKAQVVELVKKHKKAVTLAIGDGANDVSMIKTAHIGVGISGQEGMQAVLSSD 850

  Fly  1026 FSIPQFSHIAKLLLIHGRRSYKRSAALSQFVIHRGLIITTLQAVFSAVFYLSSVALYQGFLMVGY 1090
            ||..||.::.:|||:|||.||.|.....::..::....|.:...::.....|:..:|..:.:..|
Zfish   851 FSFAQFRYLQRLLLVHGRWSYLRMCTFLRYFFYKNFTFTFVHFWYAFFCGFSAQTVYDEWYITLY 915

  Fly  1091 STLYTMFPVFSLVL-DQDITSETAVTYPELYKDLSKGRSLSYKTFFIWVLISIYQGGVIMYGALI 1154
            :.:||..||..:.| |||:....:..||:||   :.|:...|.:...:..|.::.    .|.:||
Zfish   916 NLVYTALPVLGISLFDQDVNDRWSFQYPQLY---APGQMNQYFSKMAFAKILLHS----CYSSLI 973

  Fly  1155 LFV-----------DEFIHIVAISFSALIMTELIMVALTVR---------------TWHRL---- 1189
            ||.           |:...|......||:....:::|::|:               .|..|
Zfish   974 LFFVPWAAMWDTVRDDGKDIADYQSFALLAQTCLLIAVSVQLGLDTYYWTAVNHFFLWGSLSVYF 1038

  Fly  1190 MVLAELFSLALYLISLAVLHEYFDWEFIWSYDFL------------WKVSLITLVSC-LPLYIIK 1241
            .|...::|..:|||            |..|:.|:            |....:|.:.| ||:...:
Zfish  1039 AVTFTMYSNGMYLI------------FTSSFPFIGTARNSLNQPNVWLTIFLTTILCVLPVVAKR 1091

  Fly  1242 FL-----------------RKKCSPP 1250
            ||                 :.|..||
Zfish  1092 FLFIQFKPTINDKVRHKVKQAKAEPP 1117

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31729	NP_609634.1	PhoLip_ATPase_N	227..279	CDD:292826	23/51 (45%)
		ATPase-Plipid	228..1252	CDD:273734	329/1177 (28%)
		E1-E2_ATPase	323..525	CDD:278548	56/233 (24%)
		Cation_ATPase	<704..783	CDD:289987	27/78 (35%)
		HAD_like	<975..1019	CDD:304363	27/43 (63%)
		PhoLip_ATPase_C	1021..1249	CDD:292829	63/288 (22%)
atp8b5b	XP_691903.2	PhoLip_ATPase_N	25..87	CDD:292826	27/65 (42%)
		ATPase-Plipid	36..1107	CDD:273734	326/1165 (28%)
		Cation_ATPase	480..584	CDD:289987	37/142 (26%)
		HAD_like	<815..846	CDD:304363	20/30 (67%)
		PhoLip_ATPase_C	846..1100	CDD:292829	62/272 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170578132
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53737
OrthoDB	1	1.010	-	-		D587717at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.860