DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG31729 and atp11a

DIOPT Version :9

Sequence 1:	NP_609634.1	Gene:	CG31729 / 34736	FlyBaseID:	FBgn0051729	Length:	1256	Species:	Drosophila melanogaster
Sequence 2:	XP_005171058.2	Gene:	atp11a / 562925	ZFINID:	ZDB-GENE-090311-52	Length:	1212	Species:	Danio rerio

Alignment Length:	1192	Identity:	360/1192 - (30%)
Similarity:	549/1192 - (46%)	Gaps:	235/1192 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   201 CSCWRKWFRPRELRARTVNLGRVN---------TEKFPPNEIRNQKYNFITFLPLVLFEQFRFFL 256
            |:....|     :.:|||.:|...         .::||.|.|.:.||.|..|:|..||||||...
Zfish    14 CTGEENW-----VDSRTVYIGHKEPPPGTEAYIPQRFPDNRIVSSKYTFWNFIPKNLFEQFRRIA 73

  Fly   257 NLYFLLMALSQFIPDIRIGYPYTYWGPLGFVLMVTICREAVDDLRRHQRDHEVNSQKYKRLSSTN 321
            |.|||::.|.|.|.|.... |.|...||.||:.||..::..:|..||:.|:.||.      ...:
Zfish    74 NFYFLIIFLVQLIIDTPTS-PMTSGLPLFFVITVTAIKQGYEDWIRHKADNSVNQ------CPVH 131

  Fly   322 ISGYEMV---PSSKLKVGDVIIVEKNERVPADLILLRTSDRSGSVFVRTDQLDGETDWKPRLAVP 383
            |..:..|   .|.||:|||::.|::||..|.|||||.||...|:.||.|..||||:..|...||.
Zfish   132 IVQHGKVVRKQSQKLRVGDIVQVKENETFPCDLILLSTSREDGTCFVTTASLDGESSHKTYYAVQ 196

  Fly   384 YTQKLSRDSELHSIDASFYVEKPQNDIHSFIA---TFCMAD-------GSED---TGLSVENTLW 435
            .|:..|...|:.::.|:...|:||.|::.|:.   .:...|       |||:   .|.:::||.:
Zfish   197 DTKAFSTAEEVDTLHATIECEQPQPDLYKFVGRINIYLDRDEPIARPLGSENLLLRGATLKNTEY 261

  Fly   436 ANTVVAAGTATGIVIYTGCETRSVMNNSQPRSKVGLLDMEINGLTKVLFCAVLGLSLVMMMLK-- 498
            .:.|         .||||.||:..:|......|...::..:|....|..|.::..:|:..:||
Zfish   262 IHAV---------AIYTGMETKMALNYQSKSQKRSAVEKSMNAYLIVYLCILISKALINTVLKYV 317

  Fly   499 -----GFGGPWYRY-----------------MFRFVLLFSYIIPISLRVNLDM----GKAFYSW- 536
                 ....|||..                 ...|::||:||||:|:.|.::|    |..|..|
Zfish   318 WQADPNRDEPWYNQRTESERQRHVLIRAFTDFLAFMVLFNYIIPVSMYVTVEMQKFLGSYFILWD 382

  Fly   537 -QMQNDSNIQGTVVRSTTIPEELGRISYVLTDKTGTLTQNEMVFKKIHLGIVSHDADTF--HHIG 598
             .|.::...:..:|.::.:.||||::.||.||||||||:|.|..::..:     |...:  |.|
Zfish   383 DDMFDEEVGERPLVNTSDLNEELGQVEYVFTDKTGTLTENNMELRECCV-----DGHVYVPHAI- 441

  Fly   599 QMIQKLSGNILQQQQGSLSSSSSGGDSTKPMMFGNRMRRPEGWREWEAVRALALCHNVTPVSDDE 663
                 .:|.||....|.....||.|...|.             ||....|||.|||.| .|.::|
Zfish   442 -----CNGQILPGAAGMDMIDSSPGVEGKE-------------REELFFRALCLCHTV-QVKEEE 487

  Fly   664 DNRSVSTASTVTGGNNSPTKSVINIEAPGSTDTEHQ------YQAASPDEIALVKWTEQVGLTLI 722
                     ||.|     .|..|           ||      |.::||||:|||:..:::|.|.:
Zfish   488 ---------TVDG-----IKRGI-----------HQGKATSFYISSSPDEVALVEGMKRLGFTYL 527

  Fly   723 ARDLNTMTLQVKTPSEDNDILLHYQILQLFPFTSESKRMGIIVRESKTGQITFYLKGAD------ 781
            .  |....:::....::.:   .:::|.:..|.|..:||.:||| |.:|:...:.||||
Zfish   528 R--LKDSHMEILNREDEME---RFELLDVLNFDSVRRRMSVIVR-SNSGEYYLFCKGADSSVFPR 586

  Fly   782 VVMSSI------VQYNDWLSEESGNMAREGLRTLVVAKKVLTEEQYSDFETRYNAARLSITDRVA 840
            ||...:      |::|          |.||||||.||.|.|::|:|.:......:|:|::.:|..
Zfish   587 VVSGKVEQVRARVEHN----------AVEGLRTLCVAYKRLSQEEYEETCRLLTSAKLALQERDK 641

  Fly   841 KVAAVTESLERELELLCLTGVEDRLQENVRPTLELLRNAGVRVWMLTGDKLETACCIAKSSQLIG 905
            |:|...:.:|::..||..|.||||||:....|:|.|..||::||:|||||:|||.....:|:|..
Zfish   642 KLAEAYDVIEKDFILLGATAVEDRLQDKAADTIESLHKAGIKVWVLTGDKMETAAATCYASKLFH 706

  Fly   906 RN-------------QGLHVLRSVKTRTDAHQELNSFRRK---------QGHALVISGESLEVCL 948
            ||             |.||.:....:||...|. .|..|.         |.:.|:|.|.:|...|
Zfish   707 RNTQILELTTKRTEEQSLHDVLFDLSRTVLRQH-GSMTRDTFSGLSGDYQDYGLIIDGATLSAVL 770

  Fly   949 Q----------YYRPEFLELATASPAVVCCRCSPTQKAQVVALI---QKHTGKRTCAVGDGGNDV 1000
            :          .|:..|||:.....||:|||.:|.||||:|.||   ::|  ..|.|:|||.|||
Zfish   771 KPTQDATSNGGNYKEIFLEICRNCSAVLCCRMAPLQKAQIVKLIKASKEH--PITLAIGDGANDV 833

  Fly  1001 SMIQQADAGVGIEGREGRQASLAGDFSIPQFSHIAKLLLIHGRRSYKRSAALSQFVIHRGLIITT 1065
            |||.:|..|:||.|:|||||:...|::|.:|.|:.|:||:||...|.|.|.|.|:..::.:....
Zfish   834 SMILEAHVGIGIMGKEGRQAARNSDYAITKFKHLKKMLLVHGHYYYIRIAELVQYFFYKNVCFIF 898

  Fly  1066 LQAVFSAVFYLSSVALYQGFLMVGYSTLYTMFPV--FSLVLDQDITSETAVTYPELYKDLSKGRS 1128
            .|.::......|...||....:..|:..:|..|:  :|| ::|.|..:.....|.||:|::|...
Zfish   899 PQFLYQFFCGFSQQPLYDTAYLTLYNISFTSLPILLYSL-MEQHINMDILKRDPSLYRDIAKNSL 962

  Fly  1129 LSYKTFFIWVLISIYQGGVIMYGALILFVDEFI----HIVA--------------ISFSALIMTE 1175
            |::.||..|..:.::...|..:||..||.:...    .::|              :.|:.|:.|.
Zfish   963 LTWPTFIYWTFLGVFDAVVFFFGAFFLFDNTTFTSNGQLMATNTQMMFGNWTFGTLVFTVLVFTV 1027

  Fly  1176 LIMVALTVRTWHRLMVLAELFSLALYLISLAVLHEYFDWEFI----WSYDFL--------W-KVS 1227
            .:.:||....|..:.......||..|:| .::|.....|.|:    ..|.|:        | .:.
Zfish  1028 TLKLALDTHYWTWINHFVIWGSLLFYVI-FSLLWGGIIWPFLNYQRMYYVFMQMLSSGPAWLSII 1091

  Fly  1228 LITLVSCLPLYIIKFLRKKCSP 1249
            |:.:||.||..:.|.|.:...|
Zfish  1092 LLIIVSLLPDVLKKVLCRALWP 1113

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31729	NP_609634.1	PhoLip_ATPase_N	227..279	CDD:292826	24/51 (47%)
		ATPase-Plipid	228..1252	CDD:273734	354/1156 (31%)
		E1-E2_ATPase	323..525	CDD:278548	71/241 (29%)
		Cation_ATPase	<704..783	CDD:289987	24/84 (29%)
		HAD_like	<975..1019	CDD:304363	25/46 (54%)
		PhoLip_ATPase_C	1021..1249	CDD:292829	63/260 (24%)
atp11a	XP_005171058.2	P-type_ATPase_APLT_Dnf-like	47..977	CDD:319770	322/1015 (32%)
atp11a	XP_005171058.2	PhoLip_ATPase_C	854..1114	CDD:318452	64/262 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170578121
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D587717at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.850