DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG31729 and atp10d

DIOPT Version :9

Sequence 1:	NP_609634.1	Gene:	CG31729 / 34736	FlyBaseID:	FBgn0051729	Length:	1256	Species:	Drosophila melanogaster
Sequence 2:	XP_012818017.1	Gene:	atp10d / 549378	XenbaseID:	XB-GENE-1000388	Length:	1373	Species:	Xenopus tropicalis

Alignment Length:	1283	Identity:	360/1283 - (28%)
Similarity:	578/1283 - (45%)	Gaps:	297/1283 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   225 TEKFPPNEIRNQKYNFITFLPLVLFEQFRFFLNLYFLLMALSQFIPDIRIGYPYTYWGPLGFVLM 289
            |:.:..|.|:..||..:.|:|..|||||....|||||.:....::|.:..........||..||.
Frog    68 TKAYKNNRIQTTKYTLLNFIPRNLFEQFHRAANLYFLFLVFLNWVPLVEAFQKEITMLPLVAVLT 132

  Fly   290 VTICREAVDDLRRHQRDHEVNS----------QKYKRLSSTNISGYEMVPSSKLKVGDVIIVEKN 344
            :...::.::|.|:::.|..:|:          :|||.....:::           ||..|.::.:
Frog   133 IIAIKDGLEDYRKYKLDKVINNIVTQVYCRKEKKYKESCWKDVN-----------VGHFIRLQCD 186

  Fly   345 ERVPADLILLRTSDRSGSVFVRTDQLDGETDWKPRLAVPYTQKLSRDSEL--HSIDASFYVEKPQ 407
            |.:|||::||.:||..|...:.|..|||||:.|.|..|   :..|.|.|.  .........|.|.
Frog   187 EIIPADMVLLHSSDPDGICHIETSSLDGETNLKQRQVV---KGYSMDDEFDPEKFSGRIQCENPT 248

  Fly   408 NDIHSFIATFCMADGSEDTGLSVENTLWANTVVAAGTA-TGIVIYTGCETRSVMNNSQPRSKVGL 471
            :||.|| ..|......|..|||.:|.|....:|....| .|||:|.|.||::::|||.||.|...
Frog   249 SDISSF-KGFLDHPNKEKIGLSKQNLLLRGCIVRNTEAVVGIVVYAGHETKAMLNNSGPRYKRSR 312

  Fly   472 LDMEINGLTKVLFCAVLGLSLVM-------MMLKGF-----------GGPWYR------YMF-RF 511
            |:..:|  |.:|:..:|.:::.:       :.|.||           ||....      ||| ..
Frog   313 LERRLN--TDILWSVLLLIAMCLFGAIGHGLWLAGFPESPIFSIPEPGGQHTSPALAGFYMFWTM 375

  Fly   512 VLLFSYIIPISLRVNLDMGKAFYSWQMQNDSNI----QGTVV--RSTTIPEELGRISYVLTDKTG 570
            ::|...:|||||.|::::.|....:.:||||..    ..:::  |:..|.|:||::.|:.:||||
Frog   376 IILLQVLIPISLYVSIEIVKLGQIYFIQNDSEFYCEKSDSMIECRALNIAEDLGQVQYIFSDKTG 440

  Fly   571 TLTQNEMVFKKIHLGIV--SHDADT----------FH-----HIGQMIQKLSGNILQQQQG---- 614
            |||:|:|||::..:..:  ||:|:.          .|     |:..:.|.......:|::.
Frog   441 TLTENKMVFRRCSIAGMEYSHEANARRLESYQESDMHGSNLCHVTCISQSSVCKSKEQRKAASNK 505

  Fly   615 SLSSSSSGGD--------STKPMMFGNRMRR-----PEGWREWEAVR------------------ 648
            ||::.:.|.|        :.:.:.|.:.|.:     |....:::.:.
Frog   506 SLNNFAQGEDNDGASHPPNPRHVAFSSPMEKDVVPDPRLLSKFDQINPKSLYMSEEAEDTALETS 570

  Fly   649 -------ALALCHNV-------------------TPVSDDED---------NRSVSTASTVTG-- 676
                   |||:|:.|                   ||:...|:         .|.:|.:|..:|
Frog   571 YIVDFFLALAICNTVVVSLPNQPRQKVRMPSMVRTPMKSLEEIKQMFQRFSVRKLSASSFTSGKD 635

  Fly   677 -----GNN--------------SPT-----KSVINIEAPGSTDT--------------------- 696
                 |:|              |||     ||:.:::|.||.::
Frog   636 CPSENGSNFGSKLSFFTRGKLASPTAELADKSINDLQAAGSLNSTAELEPEVLEQSNFVTACDEL 700

  Fly   697 ------EHQYQAASPDEIALVKWTEQVGLTLIARDLNTMTLQVKTPSEDNDIL-----LHYQILQ 750
                  |..|:|.||||.|||.         .||..| .|||.:||.:....|     |.:|:|.
Frog   701 DKAAACELCYEAESPDEAALVH---------AARAYN-CTLQSRTPDQVTVELGFIGPLTFQVLH 755

  Fly   751 LFPFTSESKRMGIIVRESKTGQITFYLKGADVVMSSIVQYNDWLSEES----------------- 798
            :.||.|..|||.:|:|...|.::..|.||||   |:|:......||::
Frog   756 ILPFDSVRKRMSVIIRHPLTNKVVVYTKGAD---SAIMDLIAMTSEDNKAAMVKKNIQMLTQKHL 817

  Fly   799 GNMAREGLRTLVVAKKVLTEEQYSDFETRYNAARLSITDRVAKVAAVTESLERELELLCLTGVED 863
            .:.|:.|||||.:||||:|:.:|:::...:..|..||.:|...:......||.:|.||..||:||
Frog   818 DDYAKGGLRTLCIAKKVMTDSEYAEWLQSHFLAETSIDNREEMLYESAVRLETKLTLLGATGIED 882

  Fly   864 RLQENVRPTLELLRNAGVRVWMLTGDKLETACCIAKSSQLIGRNQGL-----HVLRSVKT----- 918
            ||||.|..|:|.||.||:.:|||||||.|||..||.:.:|:..:..|     |...|.:|
Frog   883 RLQEGVPDTIESLRKAGINIWMLTGDKEETAVNIAYACRLLEHSDKLFNLSKHEKESCETLMNIM 947

  Fly   919 --RTDAHQELNSF----RRKQG--HALVISGESLEVCL-QYYRPEFLELATASPAVVCCRCSPTQ 974
              ..|:..:.|:|    :.|.|  ..|||.|.:||:.: :..:.:||:|.....||:|||.:|.|
Frog   948 IDEIDSLGKPNAFSSGQQDKSGLHFGLVIDGGTLEIAMHESLQSKFLQLTERCRAVICCRATPLQ 1012

  Fly   975 KAQVVALIQKHTGKRTCAVGDGGNDVSMIQQADAGVGIEGREGRQASLAGDFSIPQFSHIAKLLL 1039
            |::||.|::.:......|:|||.|||||||.||.||||.|:||.||.::.||::..|.|:.||||
Frog  1013 KSKVVKLVRNNLQVMALAIGDGANDVSMIQVADIGVGISGQEGMQAVMSSDFAVSHFKHLRKLLL 1077

  Fly  1040 IHGRRSYKRSAALSQFVIHRGLIITTLQAVFSAVFYLSSVALYQGFLMVGYSTLYTMF-PVFSLV 1103
            :||...|.|.|.:..:..::.|:...|...:......|..|:...::::.::.|:|.. |:...:
Frog  1078 VHGHWCYTRLANMILYFFYKNLMFVNLLFWYQFFCGFSGTAMTDFWMLILFNLLFTSVPPIIYGI 1142

  Fly  1104 LDQDITSETAVTYPELYKDLSKGRSLSYKTFFIWVLISIYQGGVIMYGALILFVDEFIHIVA--- 1165
            ||:|:::||....|||||.....::....||::.:|.:.||      .....|:..|.:|.:
Frog  1143 LDKDVSAETLTALPELYKSGQTSQAYRSSTFWVTILDAFYQ------SLACFFIPYFAYIGSDLG 1201

  Fly  1166 -ISFSALIMTELIMVAL-------TVRTW-HRLMVLAEL-----FSLALYLISL----------A 1206
             .||...::|..:.|.|       ...|| |.:::.|.:     ||||...:.:          .
Frog  1202 IYSFGNFLITSALFVVLLHLLIESKSLTWIHWIVMGASIAAYFAFSLAFGAVCINCNPPANPYWI 1266

  Fly  1207 VLHEYFDWEFIWSYDFLWKVSLITL-VSCLPLYIIKFLRKKCSPPSYL 1253
            |.:...|..|       :.|.|::: ::.||.|:.:..:....|...|
Frog  1267 VQNHVRDPAF-------YLVCLLSIFIALLPRYVCRIFQGTVFPTPQL 1307

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31729	NP_609634.1	PhoLip_ATPase_N	227..279	CDD:292826	17/51 (33%)
		ATPase-Plipid	228..1252	CDD:273734	358/1277 (28%)
		E1-E2_ATPase	323..525	CDD:278548	71/229 (31%)
		Cation_ATPase	<704..783	CDD:289987	33/83 (40%)
		HAD_like	<975..1019	CDD:304363	24/43 (56%)
		PhoLip_ATPase_C	1021..1249	CDD:292829	59/256 (23%)
atp10d	XP_012818017.1	P-type_ATPase_APLT_Dnf-like	73..1191	CDD:319770	334/1153 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D587717at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010