DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG31729 and Atp8b1

DIOPT Version :9

Sequence 1:	NP_609634.1	Gene:	CG31729 / 34736	FlyBaseID:	FBgn0051729	Length:	1256	Species:	Drosophila melanogaster
Sequence 2:	NP_001001488.2	Gene:	Atp8b1 / 54670	MGIID:	1859665	Length:	1251	Species:	Mus musculus

Alignment Length:	1210	Identity:	338/1210 - (27%)
Similarity:	560/1210 - (46%)	Gaps:	215/1210 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   172 ENGSSTVFYQHNR----RKSKSRSIGNVCKLCLCSCWRKWFRPRELRAR----TVNLGRVNTEKF 228
            |:..|||..:.||    .:.|..:....|      .|:.....|:...:    ......:...|:
Mouse    34 EDQGSTVEPEQNRVNREAEKKRETFRKDC------TWQVKANDRKFHEQPHFMNTKFFCIKESKY 92

  Fly   229 PPNEIRNQKYNFITFLPLVLFEQFRFFLNLYFLLMALSQFIPDIRIGYPYTYWGPLGFVLMVTIC 293
            ..|.|:..|||..||||:.|||||:...|.|||::.:.|.||.|.....||...||..||.:|..
Mouse    93 ASNAIKTYKYNGFTFLPMNLFEQFKRAANFYFLILLILQAIPQISTLAWYTTLVPLLLVLGITAI 157

  Fly   294 REAVDDLRRHQRDHEVNSQKYKRLSSTNISGYEMVPSSKLKVGDVIIVEKNERVPADLILLRTSD 358
            ::.|||:.||:.|.|:|::..:.:..   ..::::....::|||||.::||:.:|||::||.:|:
Mouse   158 KDLVDDVARHKMDKEINNRTCEVIKD---GRFKIIKWKDIQVGDVIRLKKNDFIPADILLLSSSE 219

  Fly   359 RSGSVFVRTDQLDGETDWKPRLAVPYT-QKLSRDSELHSIDASFYVEKPQNDIHSFIATFCMADG 422
            .:...:|.|.:|||||:.|.::|:..| |.|..:..|.:.|.....|:|.|.:..|..|....
Mouse   220 PNSLCYVETAELDGETNLKFKMALEITDQYLQIEDNLATFDGFIECEEPNNRLDKFTGTLFWK-- 282

  Fly   423 SEDTGLSVENTLWANTVVA-AGTATGIVIYTGCETRSVMNNSQPRSKVGLLDMEINGLTKVLFCA 486
            ::...|..:..|....|:. .....|:||:.|.:|:.:.|:.:.|.|...:|..:|.:...:|..
Mouse   283 NQSFPLDADKILLRGCVIRNTDVCHGLVIFAGADTKIMKNSGKTRFKRTKIDYLMNYMVYTIFIV 347

  Fly   487 VL----GLSLVMMMLKGFGG--PWYRY--------------MFRFVLLFSYIIPISLRVNLD--- 528
            ::    ||::.....:...|  .||.|              .:.::::.:.::||||.|:::
Mouse   348 LILVSAGLAIGHAYWEAQVGNYSWYLYDGENATPSYRGFLNFWGYIIVLNTMVPISLYVSVEVIR 412

  Fly   529 MGKA-FYSWQMQ-----NDSNIQGTVVRSTTIPEELGRISYVLTDKTGTLTQNEMVFKK--IHLG 585
            :|:: |.:|.:|     .|:..:   .|:||:.|:||:|.|:.:|||||||||.|.|||  |:..
Mouse   413 LGQSHFINWDLQMYYAEKDTPAK---ARTTTLNEQLGQIHYIFSDKTGTLTQNIMTFKKCCINGT 474

  Fly   586 IVSHDADTFHHIGQMIQKL--------SGNILQQQQGSLSSSSSGGDSTKPMMFGNRMRRPEGWR 642
            |.....|...|....|:.:        .|.:.......:....||             :.||
Mouse   475 IYGDHRDASQHSHSKIELVDFSWNTFADGKLAFYDHYLIEQIQSG-------------KEPE--- 523

  Fly   643 EWEAVR----ALALCHNVTPVSDDEDNRSVSTASTVTGGNNSPTKSVINIEAPGSTDTEHQYQAA 703
                ||    .|::||.|  :.|..|.:                   ||            ||||
Mouse   524 ----VRQFFFLLSICHTV--MVDRIDGQ-------------------IN------------YQAA 551

  Fly   704 SPDEIALVKWTEQVGLTLIARDLNTMTLQVKTPSEDNDILLHYQILQLFPFTSESKRMGIIVRES 768
            ||||.|||......|...:||..||:|:. :..||..     |.:|.:..|.|:.|||.|||| :
Mouse   552 SPDEGALVNAARNFGFAFLARTQNTITVS-ELGSERT-----YNVLAILDFNSDRKRMSIIVR-T 609

  Fly   769 KTGQITFYLKGADVVMSSIVQYNDWLSEESGN----MAREGLRTLVVAKKVLTEEQYSDFETRYN 829
            ..|.|..|.||||.|:...:...:...:|:.:    .|.|.||||.:..|.:.|::::::..::.
Mouse   610 PEGSIRLYCKGADTVIYERLHRMNPTKQETQDALDIFASETLRTLCLCYKEIEEKEFTEWNNKFM 674

  Fly   830 AARLSITDRVAKVAAVTESLERELELLCLTGVEDRLQENVRPTLELLRNAGVRVWMLTGDKLETA 894
            ||.::.::|...:..|.|.:|::|.||..|.:||:||:.|..|:..|..|.:::|:|||||.|||
Mouse   675 AASVASSNRDEALDKVYEEIEKDLILLGATAIEDKLQDGVPETISKLAKADIKIWVLTGDKKETA 739

  Fly   895 CCIAKSSQLIGRN----QGLHVLRSVKTRTDAHQELNSFRRK-------------QGHALVISGE 942
            ..|..:.:|:..:    .|..:...:.||.:..:.......|             :..||:|:|.
Mouse   740 ENIGFACELLTEDTTICYGEDINSLLHTRMENQRNRGGVSAKFAPPVYEPFFPPGENRALIITGS 804

  Fly   943 SL-EVCLQ------------YYRPE-----------------------FLELATASPAVVCCRCS 971
            .| |:.|:            :.|.|                       |::||....||:|||.:
Mouse   805 WLNEILLEKKTKRSKILKLKFPRTEEERRMRSQSRRRLEEKKEQRQKNFVDLACECSAVICCRVT 869

  Fly   972 PTQKAQVVALIQKHTGKRTCAVGDGGNDVSMIQQADAGVGIEGREGRQASLAGDFSIPQFSHIAK 1036
            |.|||.||.|::::....|.|:|||.|||:||:.|..||||.|:||.||.::.|:|..||.::.:
Mouse   870 PKQKAMVVDLVKRYKKAITLAIGDGANDVNMIKTAHIGVGISGQEGMQAVMSSDYSFAQFRYLQR 934

  Fly  1037 LLLIHGRRSYKRSAALSQFVIHRGLIITTLQAVFSAVFYLSSVALYQGFLMVGYSTLYTMFPVFS 1101
            |||:|||.||.|.....::..::....|.:...:|.....|:...|:.:.:..|:.||:..||..
Mouse   935 LLLVHGRWSYIRMCKFLRYFFYKNFAFTLVHFWYSFFNGYSAQTAYEDWFITLYNVLYSSLPVLL 999

  Fly  1102 L-VLDQDITSETAVTYPELYKDLSKGRSLSYKTFFIWVLISIYQGGVIMY---GALILFVDE--- 1159
            : :||||::.:.::.:|.||....:....:||.||:.:|..:....|:.:   ||.:..|.:
Mouse  1000 MGLLDQDVSDKLSLRFPGLYVVGQRDLLFNYKRFFVSLLHGVLTSMVLFFIPLGAYLQTVGQDGE 1064

  Fly  1160 -------FIHIVAISFSALIMTELIMVALTVRTWHRLMVLAELFSLALYL-----ISLAVLHEYF 1212
                   |...||   |||::|....:.|....|..:...:...|:|||.     ...|.:|..|
Mouse  1065 APSDYQSFAVTVA---SALVITVNFQIGLDTSYWTFVNAFSIFGSIALYFGIMFDFHSAGIHVLF 1126

  Fly  1213 DWEFIWS--------YDFLWKVSLITLVSC-LPLYIIKFL 1243
            ...|.::        ..::|...::|:..| ||:..|:||
Mouse  1127 PSAFQFTGTASNALRQPYIWLTIILTVAVCLLPVVAIRFL 1166

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31729	NP_609634.1	PhoLip_ATPase_N	227..279	CDD:292826	23/51 (45%)
		ATPase-Plipid	228..1252	CDD:273734	327/1146 (29%)
		E1-E2_ATPase	323..525	CDD:278548	56/223 (25%)
		Cation_ATPase	<704..783	CDD:289987	33/78 (42%)
		HAD_like	<975..1019	CDD:304363	23/43 (53%)
		PhoLip_ATPase_C	1021..1249	CDD:292829	63/251 (25%)
Atp8b1	NP_001001488.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..52		6/17 (35%)
		PhoLip_ATPase_N	86..142	CDD:292826	23/55 (42%)
		ATPase-Plipid	92..1179	CDD:273734	327/1146 (29%)
		E1-E2_ATPase	171..>234	CDD:278548	19/65 (29%)
		Cation_ATPase	534..628	CDD:289987	45/133 (34%)
		HAD_like	<875..919	CDD:304363	22/43 (51%)
		PhoLip_ATPase_C	919..1173	CDD:292829	63/251 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167835013
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53737
OrthoDB	1	1.010	-	-		D587717at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.860