DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG31729 and Atp8b2

DIOPT Version :9

Sequence 1:	NP_609634.1	Gene:	CG31729 / 34736	FlyBaseID:	FBgn0051729	Length:	1256	Species:	Drosophila melanogaster
Sequence 2:	NP_001355579.1	Gene:	Atp8b2 / 54667	MGIID:	1859660	Length:	1209	Species:	Mus musculus

Alignment Length:	1172	Identity:	349/1172 - (29%)
Similarity:	535/1172 - (45%)	Gaps:	215/1172 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   207 WFRPRELRARTVNLGRVNTEKF--PPNEIRNQKYNFITFLPLVLFEQFRFFLNLYFLLMALSQFI 269
            |....|.|||..:  |...|||  ..|.|:..|||.:||||:.|||||:...|.|||.:.:.|.|
Mouse    27 WGTEEERRARAND--REYNEKFQYASNCIKTSKYNIVTFLPVNLFEQFQEVANTYFLFLLILQLI 89

  Fly   270 PDIRIGYPYTYWGPLGFVLMVTICREAVDDLRRHQRDHEVNSQKYKRLSSTNISG-YEMVPSSKL 333
            |.|.....:|...||..||.:|..::|.||..||:.|::||:    |.|...|:| .:......:
Mouse    90 PQISSLSWFTTIVPLVLVLTITAVKDATDDYFRHKSDNQVNN----RHSQVLINGVLQQEQWMNV 150

  Fly   334 KVGDVIIVEKNERVPADLILLRTSDRSGSVFVRTDQLDGETDWKPRLAVPYTQKLSRDSELHSID 398
            .|||:|.:|.|:.|.|||:||.:|:..|..::.|.:|||||:.|.|.|:|.|.:|...|:|...|
Mouse   151 CVGDIIKLENNQFVAADLLLLSSSEPHGLCYIETAELDGETNMKVRQAIPVTSELGDVSQLARFD 215

  Fly   399 ASFYVEKPQNDIHSFIATFCMADGSED--------TGLSVENTLWANTVVAAGTATGIVIYTGCE 455
            .....|.|.|.:..|..|....:....        .|..:.||.|         ..|:||:.|.:
Mouse   216 GEVICEPPNNKLDKFSGTLYWKENKFPLSNQNMLLRGCVLRNTEW---------CFGLVIFAGPD 271

  Fly   456 TRSVMNNSQPRSKVGLLDMEINGLTKVLFCAVLGLSLVMMMLKGFGG---------------PW- 504
            |:.:.|:.:.:.|...:|..:|  |.||:  :.|..:.|.::...|.               ||
Mouse   272 TKLMQNSGRTKFKRTSIDRLMN--TLVLW--IFGFLVCMGVILAIGNAIWEHEVGTRFQVYLPWD 332

  Fly   505 ----------YRYMFRFVLLFSYIIPISLRVNLDMGKAFYSWQMQNDSNI------QGTVVRSTT 553
                      :...:.::::.:.::||||.|::::.:..:|:.:..|..:      .....|:||
Mouse   333 EAVDSAFFSGFLSFWSYIIILNTVVPISLYVSVEVIRLGHSYFINWDKKMFCMKKRTPAEARTTT 397

  Fly   554 IPEELGRISYVLTDKTGTLTQNEMVFKKIHLGIVSHDADTFHHIGQMIQKLSGNILQQQQGSLSS 618
            :.||||::.|:.:|||||||||.|||.|..:...|: .|.|..:|...:.
Mouse   398 LNEELGQVEYIFSDKTGTLTQNIMVFNKCSINGHSY-GDVFDVLGHKAEL--------------- 446

  Fly   619 SSSGGDSTKPMMFGNRMRRPEGWREW-----EAV-----------RALALCHNVTPVSDDEDNRS 667
                |:..:|:.|.......:.:..|     |||           |.|:|||.   |..:|.|
Mouse   447 ----GERPEPVDFSFNPLADKKFLFWDSSLLEAVKMGDPHTHEFFRLLSLCHT---VMSEEKN-- 502

  Fly   668 VSTASTVTGGNNSPTKSVINIEAPGSTDTEHQYQAASPDEIALVKWTEQVGLTLIARDLNTMTLQ 732
                                       :.|..|:|.||||.|||......|....:|...|:|:
Mouse   503 ---------------------------EGELYYKAQSPDEGALVTAARNFGFVFRSRTPKTITV- 539

  Fly   733 VKTPSEDNDILLHYQILQLFPFTSESKRMGIIVRESKTGQITFYLKGADVVM---------SSIV 788
                 .:....:.||:|.:..|.:..|||.:|||..: |:|..|.||||.::         ..:.
Mouse   540 -----HELGTAITYQLLAILDFNNIRKRMSVIVRNPE-GKIRLYCKGADTILLDRLHPPTQELLS 598

  Fly   789 QYNDWLSEESGNMAREGLRTLVVAKKVLTEEQYSDFETRYNAARLSITDRVAKVAAVTESLEREL 853
            ...|.|:|.:|    :||||||:|.|.|.||.|.::..|...|.|:...|..::|::.|.:|.::
Mouse   599 STTDHLNEYAG----DGLRTLVLAYKDLDEEYYEEWARRRLQASLAQDSREDRLASIYEEVESDM 659

  Fly   854 ELLCLTGVEDRLQENVRPTLELLRNAGVRVWMLTGDKLETACCIAKSSQLIGRNQGLHVLRSVKT 918
            .||..|.:||:||:.|..|:.||..|.:::|:|||||.|||..|..|.:::..:.....:.:..|
Mouse   660 MLLGATAIEDKLQQGVPETIALLTLANIKIWVLTGDKQETAVNIGYSCKMLTDDMTEVFVVTGHT 724

  Fly   919 RTDAHQELNSFRRK--------------QG-----------------HALVISGESLEVCLQY-Y 951
            ..:..:||...|:|              ||                 :||||:|.||...|:. .
Mouse   725 VLEVREELRKARKKMVDSSHAVGNGFTYQGNLSSSKLTSVLEAVAGEYALVINGHSLAHALEADM 789

  Fly   952 RPEFLELATASPAVVCCRCSPTQKAQVVALIQKHTGKRTCAVGDGGNDVSMIQQADAGVGIEGRE 1016
            ..||||.|.|..||:|||.:|.||||||.|::|:....|.|:|||.||||||:.|..||||.|:|
Mouse   790 ELEFLETACACKAVICCRVTPLQKAQVVELVKKYKKAVTLAIGDGANDVSMIKTAHIGVGISGQE 854

  Fly  1017 GRQASLAGDFSIPQFSHIAKLLLIHGRRSYKRSAALSQFVIHRGLIITTLQAVFSAVFYLSSVAL 1081
            |.||.||.|:|..||..:.:|||:|||.||.|......:..::....|.:...|......|:..:
Mouse   855 GIQAVLASDYSFSQFKFLQRLLLVHGRWSYLRMCKFLCYFFYKNFAFTMVHFWFGFFCGFSAQTV 919

  Fly  1082 YQGFLMVGYSTLYTMFPVFSL-VLDQDITSETAVTYPELYKDLSKGRSLSYKTFFIWVLISIYQG 1145
            |..:.:..|:.:||..||.:: |.|||:..:.::.||:||:........:.:.|||.:...||.
Mouse   920 YDQYFITLYNIVYTSLPVLAMGVFDQDVPEQRSMEYPKLYEPGQLNLLFNKREFFICIAQGIYT- 983

  Fly  1146 GVIMY--------------GALILFVDEFIHIVAISFSALIMTELIMVALTVRTWHRLMVLAELF 1196
            .|:|:              |..:.....|...||.|   |::...:.:.|....|..:.......
Mouse   984 SVLMFFIPYGVFAEATRDDGTQLADYQSFAVTVATS---LVIVVSVQIGLDTGYWTAINHFFIWG 1045

  Fly  1197 SLALYLISLAVLHE--YFD-----WEFI------WSYDFLW-KVSLITLVSCLPLYIIKFLRKKC 1247
            |||:|...|..:|.  .||     :.|:      .:...:| .::|.|.|..:|:...:|||...
Mouse  1046 SLAVYFAILFAMHSNGLFDMFPNQFRFVGNAQNTLAQPTVWLTIALTTAVCIMPVVAFRFLRLSL 1110

  Fly  1248 SP 1249
            .|
Mouse  1111 KP 1112

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31729	NP_609634.1	PhoLip_ATPase_N	227..279	CDD:292826	24/53 (45%)
		ATPase-Plipid	228..1252	CDD:273734	341/1151 (30%)
		E1-E2_ATPase	323..525	CDD:278548	60/236 (25%)
		Cation_ATPase	<704..783	CDD:289987	28/78 (36%)
		HAD_like	<975..1019	CDD:304363	26/43 (60%)
		PhoLip_ATPase_C	1021..1249	CDD:292829	64/256 (25%)
Atp8b2	NP_001355579.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	12..36		3/8 (38%)
		P-type_ATPase_APLT_Dnf-like	50..991	CDD:319770	314/1021 (31%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1179..1209
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167835012
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53737
OrthoDB	1	1.010	-	-		D587717at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.860