Protein Alignment CG31729 and ATP8B1

DIOPT Version :9

• Sequence 1: NP_609634.1
• Gene: CG31729 / 34736
• FlyBaseID: FBgn0051729
• Length: 1256
• Species: Drosophila melanogaster
• Sequence 2: NP_001361314.1
• Gene: ATP8B1 / 5205
• HGNCID: 3706
• Length: 1251
• Species: Homo sapiens
• Alignment Length: 1164
• Identity: 335/1164 - (28%)
• Similarity: 548/1164 - (47%)
• Gaps: 227/1164 - (19%)

  Fly   223 VNTEKFPPNEIRNQKYNFITFLPLVLFEQFRFFLNLYFLLMALSQFIPDIRIGYPYTYWGPLGFV 287
            :...|:..|.|:..|||..||:|:.|||||:...|||||.:.:.|.:|.|.....||...||..|
Human    87 IKESKYANNAIKTYKYNAFTFIPMNLFEQFKRAANLYFLALLILQAVPQISTLAWYTTLVPLLVV 151

  Fly   288 LMVTICREAVDDLRRHQRDHEVNSQKYKRLSSTNISGYEMVPSSKLKVGDVIIVEKNERVPADLI 352
            |.||..::.|||:.||:.|.|:|::..:.:..   ..:::....:::|||||.::||:.||||::
Human   152 LGVTAIKDLVDDVARHKMDKEINNRTCEVIKD---GRFKVAKWKEIQVGDVIRLKKNDFVPADIL 213

  Fly   353 LLRTSDRSGSVFVRTDQLDGETDWKPRLAVPYT-QKLSRDSELHSIDASFYVEKPQNDIHSFIAT 416
            ||.:|:.:...:|.|.:|||||:.|.::::..| |.|.|:..|.:.|.....|:|.|.:..|..|
Human   214 LLSSSEPNSLCYVETAELDGETNLKFKMSLEITDQYLQREDTLATFDGFIECEEPNNRLDKFTGT 278

  Fly   417 FCMADGSEDTGLSVENTLWANT--------VVAAGTAT-------GIVIYTGCETRSVMNNSQPR 466
            .                .|.||        ::..|...       |:||:.|.:|:.:.|:.:.|
Human   279 L----------------FWRNTSFPLDADKILLRGCVIRNTDFCHGLVIFAGADTKIMKNSGKTR 327

  Fly   467 SKVGLLDMEINGLTKVLFCAVLGLSLVMMMLKGF------GGPWYRY-------MFR-FVLLFSY 517
            .|...:|..:|.:...:|..::.||..:.:...:      ...||.|       .:| |::.:.|
Human   328 FKRTKIDYLMNYMVYTIFVVLILLSAGLAIGHAYWEAQVGNSSWYLYDGEDDTPSYRGFLIFWGY 392

  Fly   518 II------PISLRVNLD---MGKA-FYSWQMQ-----NDSNIQGTVVRSTTIPEELGRISYVLTD 567
            ||      ||||.|:::   :|:: |.:|.:|     .|:..:   .|:||:.|:||:|.|:.:|
Human   393 IIVLNTMVPISLYVSVEVIRLGQSHFINWDLQMYYAEKDTPAK---ARTTTLNEQLGQIHYIFSD 454

  Fly   568 KTGTLTQNEMVFKK--IHLGIVSHDADTFHHIGQMIQKLSGNILQQQQGSLSSSSSGGDSTKPMM 630
            ||||||||.|.|||  |:..|.....|...|        :.|.::|...|.::.:.|    |...
Human   455 KTGTLTQNIMTFKKCCINGQIYGDHRDASQH--------NHNKIEQVDFSWNTYADG----KLAF 507

  Fly   631 FGNRM-------RRPEGWREWEAVR----ALALCHNVTPVSDDEDNRSVSTASTVTGGNNSPTKS 684
            :.:.:       :.||       ||    .||:||.|
Human   508 YDHYLIEQIQSGKEPE-------VRQFFFLLAVCHTV---------------------------- 537

  Fly   685 VINIEAPGSTDTEHQYQAASPDEIALVKWTEQVGLTLIARDLNTMTLQVKTPSEDNDILLHYQIL 749
                 ....||.:..||||||||.|||......|...:||..||:|:. :..:|..     |.:|
Human   538 -----MVDRTDGQLNYQAASPDEGALVNAARNFGFAFLARTQNTITIS-ELGTERT-----YNVL 591

  Fly   750 QLFPFTSESKRMGIIVRESKTGQITFYLKGADVVMSSIVQYNDWLSEESGN----MAREGLRTLV 810
            .:..|.|:.|||.|||| :..|.|..|.||||.|:...:...:...:|:.:    .|.|.||||.
Human   592 AILDFNSDRKRMSIIVR-TPEGNIKLYCKGADTVIYERLHRMNPTKQETQDALDIFANETLRTLC 655

  Fly   811 VAKKVLTEEQYSDFETRYNAARLSITDRVAKVAAVTESLERELELLCLTGVEDRLQENVRPTLEL 875
            :..|.:.|::::::..::.||.::.|:|...:..|.|.:|::|.||..|.:||:||:.|..|:..
Human   656 LCYKEIEEKEFTEWNKKFMAASVASTNRDEALDKVYEEIEKDLILLGATAIEDKLQDGVPETISK 720

  Fly   876 LRNAGVRVWMLTGDKLETACCIAKSSQLIGR----------NQGLHV-LRSVKTRTDAHQEL--- 926
            |..|.:::|:|||||.|||..|..:.:|:..          |..||. :.:.:.|...:.:.
Human   721 LAKADIKIWVLTGDKKETAENIGFACELLTEDTTICYGEDINSLLHARMENQRNRGGVYAKFAPP 785

  Fly   927 --NSFRRKQGH-ALVISGESL-EVCLQ------------YYRPE--------------------- 954
              .||....|: ||:|:|..| |:.|:            :.|.|
Human   786 VQESFFPPGGNRALIITGSWLNEILLEKKTKRNKILKLKFPRTEEERRMRTQSKRRLEAKKEQRQ 850

  Fly   955 --FLELATASPAVVCCRCSPTQKAQVVALIQKHTGKRTCAVGDGGNDVSMIQQADAGVGIEGREG 1017
              |::||....||:|||.:|.|||.||.|::::....|.|:|||.|||:||:.|..||||.|:||
Human   851 KNFVDLACECSAVICCRVTPKQKAMVVDLVKRYKKAITLAIGDGANDVNMIKTAHIGVGISGQEG 915

  Fly  1018 RQASLAGDFSIPQFSHIAKLLLIHGRRSYKRSAALSQFVIHRGLIITTLQAVFSAVFYLSSVALY 1082
            .||.::.|:|..||.::.:|||:|||.||.|.....::..::....|.:...:|.....|:...|
Human   916 MQAVMSSDYSFAQFRYLQRLLLVHGRWSYIRMCKFLRYFFYKNFAFTLVHFWYSFFNGYSAQTAY 980

  Fly  1083 QGFLMVGYSTLYTMFPVFSL-VLDQDITSETAVTYPELYKDLSKGRSLSYKTFFIWVLISIYQGG 1146
            :.:.:..|:.|||..||..: :||||::.:.::.:|.||....:....:||.||:.:|..:....
Human   981 EDWFITLYNVLYTSLPVLLMGLLDQDVSDKLSLRFPGLYIVGQRDLLFNYKRFFVSLLHGVLTSM 1045

  Fly  1147 VIMY---GALILFVDE----------FIHIVAISFSALIMTELIMVALTVRTWHRLMVLAELFSL 1198
            ::.:   ||.:..|.:          |...:|   |||::|....:.|....|..:...:...|:
Human  1046 ILFFIPLGAYLQTVGQDGEAPSDYQSFAVTIA---SALVITVNFQIGLDTSYWTFVNAFSIFGSI 1107

  Fly  1199 ALYL-----ISLAVLHEYFDWEFIWS--------YDFLWKVSLITLVSC-LPLYIIKFL 1243
            |||.     ...|.:|..|...|.::        ..::|...::.:..| ||:..|:||
Human  1108 ALYFGIMFDFHSAGIHVLFPSAFQFTGTASNALRQPYIWLTIILAVAVCLLPVVAIRFL 1166

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG31729	NP_609634.1	PhoLip_ATPase_N	227..279	CDD:292826	22/51 (43%)
		ATPase-Plipid	228..1252	CDD:273734	334/1159 (29%)
		E1-E2_ATPase	323..525	CDD:278548	62/237 (26%)
		Cation_ATPase	<704..783	CDD:289987	32/78 (41%)
		HAD_like	<975..1019	CDD:304363	23/43 (53%)
		PhoLip_ATPase_C	1021..1249	CDD:292829	61/251 (24%)
ATP8B1	NP_001361314.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..54
		P-type_ATPase_APLT_Dnf-like	94..1051	CDD:319770	308/1037 (30%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165144906
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53737
OrthoDB	1	1.010	-	-		D587717at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.860