DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG31729 and ATP8A2

DIOPT Version :9

Sequence 1:NP_609634.1 Gene:CG31729 / 34736 FlyBaseID:FBgn0051729 Length:1256 Species:Drosophila melanogaster
Sequence 2:NP_057613.4 Gene:ATP8A2 / 51761 HGNCID:13533 Length:1188 Species:Homo sapiens


Alignment Length:1120 Identity:328/1120 - (29%)
Similarity:528/1120 - (47%) Gaps:170/1120 - (15%)


- Green bases have known domain annotations that are detailed below.


  Fly   175 SSTVFYQHNRRKSKSRSIGNVCKLCLCSCWRKWFRPRELRARTVNLGRVNTEKFPPNEIRNQKYN 239
            ||..:.:.....|::.|:|:               ..|..|||:.|.:.:..||..|:|...||:
Human    30 SSLGYKKAEDEMSRATSVGD---------------QLEAPARTIYLNQPHLNKFRDNQISTAKYS 79

  Fly   240 FITFLPLVLFEQFRFFLNLYFLLMALSQFIPDIRIGYPYTYWGPLGFVLMVTICREAVDDLRRHQ 304
            .:||||..|:||.|...|.:||.:||.|.|||:.....||...||..:|.:...:|.|:|.:||:
Human    80 VLTFLPRFLYEQIRRAANAFFLFIALLQQIPDVSPTGRYTTLVPLIIILTIAGIKEIVEDFKRHK 144

  Fly   305 RDHEVNSQKYKRLSSTNISGYEMVPSSKLKVGDVIIVEKNERVPADLILLRTSDRSGSVFVRTDQ 369
            .|:.||.:|...|.:   ..:..:...::.|||::.|...:.:|||::||.:|:.....:|.|..
Human   145 ADNAVNKKKTIVLRN---GMWHTIMWKEVAVGDIVKVVNGQYLPADVVLLSSSEPQAMCYVETAN 206

  Fly   370 LDGETDWKPRLAVPYTQKLSRDSELHSIDASFYVEKPQNDIHSFIATF------CMADGSED--- 425
            |||||:.|.|..:.:|..:.....|..:..:...|.|...::.|....      .:|.|.:.   
Human   207 LDGETNLKIRQGLSHTADMQTREVLMKLSGTIECEGPNRHLYDFTGNLNLDGKSLVALGPDQILL 271

  Fly   426 TGLSVENTLWANTVVAAGTATGIVIYTGCETRSVMNNSQPRSKVGLLDMEINGLTKVLFCAVLGL 490
            .|..:.||.|         ..|||:|||.:|: :|.||   :|..|....:..:|.|....:.|:
Human   272 RGTQLRNTQW---------VFGIVVYTGHDTK-LMQNS---TKAPLKRSNVEKVTNVQILVLFGI 323

  Fly   491 SLVMMMLKGFGG----------PWY------------RYMFRFVLLFSYIIPISLRVNLDMGK-- 531
            .|||.::...|.          .||            ..:..|::|::.:|||||.|.|::.|  
Human   324 LLVMALVSSAGALYWNRSHGEKNWYIKKMDTTSDNFGYNLLTFIILYNNLIPISLLVTLEVVKYT 388

  Fly   532 --AFYSW--QMQNDSNIQGTVVRSTTIPEELGRISYVLTDKTGTLTQNEMVFKKIHLGIVSHDAD 592
              .|.:|  .|....|....:.|::.:.||||::.|:.:|||||||.|.|.|||..:..|     
Human   389 QALFINWDTDMYYIGNDTPAMARTSNLNEELGQVKYLFSDKTGTLTCNIMNFKKCSIAGV----- 448

  Fly   593 TFHHIGQMIQKLSGNILQQQQGSLSSSSSGGDSTKPMMFGN-RMRRPEGWREWEAVRALALCHNV 656
            |:.|..::.::.|.:...:.....|.|.   |...|.:..| ..|.|......|.:..||:||.|
Human   449 TYGHFPELAREPSSDDFCRMPPPCSDSC---DFDDPRLLKNIEDRHPTAPCIQEFLTLLAVCHTV 510

  Fly   657 TPVSDDEDNRSVSTASTVTGGNNSPTKSVINIEAPGSTDTEHQYQAASPDEIALVKWTEQVGLTL 721
            .|..|               |:|     :|             |||:||||.||||..:::|...
Human   511 VPEKD---------------GDN-----II-------------YQASSPDEAALVKGAKKLGFVF 542

  Fly   722 IARDLNTMTLQVKTPSEDNDILLHYQILQLFPFTSESKRMGIIVRESKTGQITFYLKGAD-VVMS 785
            .||...::.::.....:.      :.||.:..|:|:.|||.:||| :.:|::..|.|||| |:..
Human   543 TARTPFSVIIEAMGQEQT------FGILNVLEFSSDRKRMSVIVR-TPSGRLRLYCKGADNVIFE 600

  Fly   786 SIVQYNDWLSEESGNM---AREGLRTLVVAKKVLTEEQYSDFETRYNAARLSITDRVAKVAAVTE 847
            .:.:.:.::.|...::   |.||||||.||...|:|.:|.::...|..|...:.||..::....|
Human   601 RLSKDSKYMEETLCHLEYFATEGLRTLCVAYADLSENEYEEWLKVYQEASTILKDRAQRLEECYE 665

  Fly   848 SLERELELLCLTGVEDRLQENVRPTLELLRNAGVRVWMLTGDKLETACCIAKSSQLIGRNQGLHV 912
            .:|:.|.||..|.:|||||..|..|:..|..|.:::|:|||||.|||..|..|.:|:.:|..|.:
Human   666 IIEKNLLLLGATAIEDRLQAGVPETIATLLKAEIKIWVLTGDKQETAINIGYSCRLVSQNMALIL 730

  Fly   913 LRSVK---TRTDAHQEL----NSFRRKQGHALVISGESLEVCLQY-YRPEFLELATASPAVVCCR 969
            |:...   ||....|..    |...::...||:|.|.:|:..|.: .|..||:||.:..||:|||
Human   731 LKEDSLDATRAAITQHCTDLGNLLGKENDVALIIDGHTLKYALSFEVRRSFLDLALSCKAVICCR 795

  Fly   970 CSPTQKAQVVALIQKHTGKRTCAVGDGGNDVSMIQQADAGVGIEGREGRQASLAGDFSIPQFSHI 1034
            .||.||:::|.:::|.....|.|:|||.|||.|||.|..||||.|.||.||:...|::|.|||::
Human   796 VSPLQKSEIVDVVKKRVKAITLAIGDGANDVGMIQTAHVGVGISGNEGMQATNNSDYAIAQFSYL 860

  Fly  1035 AKLLLIHGRRSYKRSAALSQFVIHRGLIITTLQAVFSAVFYLSSVALYQGFLMVGYSTLYTMFPV 1099
            .||||:||..||.|......:..::.:::..::..|:.|...|...|::.:.:..|:.::|..|.
Human   861 EKLLLVHGAWSYNRVTKCILYCFYKNVVLYIIELWFAFVNGFSGQILFERWCIGLYNVIFTALPP 925

  Fly  1100 FSL-VLDQDITSETAVTYPELYKDLSKGRSLSYKTFFIWVLISIYQGGVI--MYGALILF----- 1156
            |:| :.::..|.|:.:.:|:|||....|...:.|.|  |       |..|  :..:||||     
Human   926 FTLGIFERSCTQESMLRFPQLYKITQNGEGFNTKVF--W-------GHCINALVHSLILFWFPMK 981

  Fly  1157 ------------VDEFIHIVAISFSALIMTELIMVALTVRTWHRLMVLAELFSLALYLISLAVLH 1209
                        ..:::.:..|.::.:::|..:...|....|.:...||...|:..:|:      
Human   982 ALEHDTVLTSGHATDYLFVGNIVYTYVVVTVCLKAGLETTAWTKFSHLAVWGSMLTWLV------ 1040

  Fly  1210 EYFDWEFIWSYDFLW 1224
                  |...|..:|
Human  1041 ------FFGIYSTIW 1049

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG31729NP_609634.1 PhoLip_ATPase_N 227..279 CDD:292826 23/51 (45%)
ATPase-Plipid 228..1252 CDD:273734 317/1067 (30%)
E1-E2_ATPase 323..525 CDD:278548 58/232 (25%)
Cation_ATPase <704..783 CDD:289987 27/79 (34%)
HAD_like <975..1019 CDD:304363 22/43 (51%)
PhoLip_ATPase_C 1021..1249 CDD:292829 50/224 (22%)
ATP8A2NP_057613.4 ATPase-Plipid 68..1106 CDD:273734 317/1067 (30%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1162..1188
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165144887
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG53737
OrthoDB 1 1.010 - - D587717at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
43.860

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