DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG31729 and Atp9b

DIOPT Version :9

Sequence 1:	NP_609634.1	Gene:	CG31729 / 34736	FlyBaseID:	FBgn0051729	Length:	1256	Species:	Drosophila melanogaster
Sequence 2:	XP_006526569.1	Gene:	Atp9b / 50771	MGIID:	1354757	Length:	1167	Species:	Mus musculus

Alignment Length:	1103	Identity:	682/1103 - (61%)
Similarity:	827/1103 - (74%)	Gaps:	74/1103 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly   198 LCLCSCWRKWF-----RPRELRARTVNLG--RVNTEKFPPNEIRNQKYNFITFLPLVLFEQFRFF 255
            ||...|  .|.     |.:||:||||.||  ....||.|.|.|:|||||..||:|.||:|||:||
Mouse    94 LCTSCC--DWLINVCQRKKELKARTVWLGCPEKCEEKHPRNSIKNQKYNVFTFIPGVLYEQFKFF 156

  Fly   256 LNLYFLLMALSQFIPDIRIGYPYTYWGPLGFVLMVTICREAVDDLRRHQRDHEVNSQKYKRLSST 320
            ||||||:::.|||:|.::|||.||||.||||||.|||.|||:|:.||.|||.|:|||.|.:|:
Mouse   157 LNLYFLVVSCSQFVPALKIGYLYTYWAPLGFVLAVTIAREAIDEFRRFQRDKEMNSQLYSKLT-- 219

  Fly   321 NISGYEMVPSSKLKVGDVIIVEK---------------------NERVPADLILLRTSDRSGSVF 364
             :.|...|.||.::|||:|||||                     |:|:|:|::.||||:::||.|
Mouse   220 -VRGKVQVKSSDIQVGDLIIVEKAFLSCGQHPLMYMLQASASFQNQRIPSDMVFLRTSEKAGSCF 283

  Fly   365 VRTDQLDGETDWKPRLAVPYTQKLSRDSELHSIDASFYVEKPQNDIHSFIATFCMADGSE--DTG 427
            :||||||||||||.::||..||:|....:|.||.|..|.:|||.|||||..||...|...  ...
Mouse   284 IRTDQLDGETDWKLKVAVSCTQRLPALGDLFSISAYVYAQKPQLDIHSFEGTFTREDSDPPIHES 348

  Fly   428 LSVENTLWANTVVAAGTATGIVIYTGCETRSVMNNSQPRSKVGLLDMEINGLTKVLFCAVLGLSL 492
            ||:||||||:|:||:||..|:|||||.|||||||.|.|::||||||:|:|.|||.||.|::.||:
Mouse   349 LSIENTLWASTIVASGTVIGVVIYTGKETRSVMNTSNPKNKVGLLDLELNQLTKALFLALVVLSV 413

  Fly   493 VMMMLKGFGGPWYRYMFRFVLLFSYIIPISLRVNLDMGKAFYSWQMQNDSNIQGTVVRSTTIPEE 557
            ||:.|:||.|||||.:|||:||||||||||||||||||||.|.|.:..|.||.|||||::|||||
Mouse   414 VMVTLQGFAGPWYRNLFRFLLLFSYIIPISLRVNLDMGKAAYGWMIMKDENIPGTVVRTSTIPEE 478

  Fly   558 LGRISYVLTDKTGTLTQNEMVFKKIHLGIVSHDADTFHHIGQMIQKLSGNILQQQQGSLSSSS-- 620
            |||:.|:||||||||||||||||::|||.||:..||...|...:......:..|..|...||:
Mouse   479 LGRLVYLLTDKTGTLTQNEMVFKRLHLGTVSYGTDTMDEIQSHVLNSYLQVHSQPSGHNPSSAPL 543

  Fly   621 SGGDSTKPMMFGNRMRRPEGWREWEAVRALALCHNVTPVSDDEDNRSVSTASTVTGGNNSPTKSV 685
            ....|:.|     ::::....|..|||:|:|||||||||.:        ..:.:||....
Mouse   544 RRSQSSTP-----KVKKSVSSRIHEAVKAIALCHNVTPVYE--------ARAGITGETEF----- 590

  Fly   686 INIEAPGS-TDTEHQYQAASPDEIALVKWTEQVGLTLIARDLNTMTLQVKTPSEDNDILLHYQIL 749
              .||... :|....|||:||||:|||:|||.||||||:|||.:|  |:||||..   :|.|.||
Mouse   591 --AEADQDFSDENRTYQASSPDEVALVRWTESVGLTLISRDLASM--QLKTPSGQ---VLTYCIL 648

  Fly   750 QLFPFTSESKRMGIIVRESKTGQITFYLKGADVVMSSIVQYNDWLSEESGNMAREGLRTLVVAKK 814
            |:|||||||||||||||:..|.:||||:|||||.||:||||||||.||.|||||||||||||||:
Mouse   649 QMFPFTSESKRMGIIVRDESTAEITFYMKGADVAMSTIVQYNDWLEEECGNMAREGLRTLVVAKR 713

  Fly   815 VLTEEQYSDFETRYNAARLSITDRVAKVAAVTESLERELELLCLTGVEDRLQENVRPTLELLRNA 879
            .||||||.|||:||:.|:|||.||..|||||.||||||:||||||||||:||.:||||||:||||
Mouse   714 TLTEEQYQDFESRYSQAKLSIHDRALKVAAVVESLEREMELLCLTGVEDQLQADVRPTLEMLRNA 778

  Fly   880 GVRVWMLTGDKLETACCIAKSSQLIGRNQGLHVLRSVKTRTDAHQELNSFRRKQGHALVISGESL 944
            |:::|||||||||||.||||||.|:.|.|.:||.|.|.:|.:||.|||:||||...||||||:||
Mouse   779 GIKIWMLTGDKLETATCIAKSSHLVSRTQDIHVFRPVTSRGEAHLELNAFRRKHDCALVISGDSL 843

  Fly   945 EVCLQYYRPEFLELATASPAVVCCRCSPTQKAQVVALIQKHTGKRTCAVGDGGNDVSMIQQADAG 1009
            ||||:||..|.:|||...||||||||||||||.:|.|:::||.|||||:|||||||||||.||.|
Mouse   844 EVCLRYYEHELVELACQCPAVVCCRCSPTQKAHIVTLLRQHTRKRTCAIGDGGNDVSMIQAADCG 908

  Fly  1010 VGIEGREGRQASLAGDFSIPQFSHIAKLLLIHGRRSYKRSAALSQFVIHRGLIITTLQAVFSAVF 1074
            :||||:||:|||||.||||.||.||.:||::|||.||||||||.|||:||||||:|:|||||:||
Mouse   909 IGIEGKEGKQASLAADFSITQFRHIGRLLMVHGRNSYKRSAALGQFVMHRGLIISTMQAVFSSVF 973

  Fly  1075 YLSSVALYQGFLMVGYSTLYTMFPVFSLVLDQDITSETAVTYPELYKDLSKGRSLSYKTFFIWVL 1139
            |.:||.||||||||||:|:||||||||||||||:..|.|:.||||||||:||||||:|||.||||
Mouse   974 YFASVPLYQGFLMVGYATIYTMFPVFSLVLDQDVKPEMAILYPELYKDLTKGRSLSFKTFLIWVL 1038

  Fly  1140 ISIYQGGVIMYGALILFVDEFIHIVAISFSALIMTELIMVALTVRTWHRLMVLAELFSLALYLIS 1204
            |||||||::|||||:||.|||:|:|||||:|||:|||:|||||:||||.|||:||..||..|:.|
Mouse  1039 ISIYQGGILMYGALLLFEDEFVHVVAISFTALILTELLMVALTIRTWHWLMVVAEFLSLGCYVAS 1103

  Fly  1205 LAVLHEYF-----------DWEFIWSYDFLWKVSLITLVSCLPLYIIKFLRKKCSPPSYLKLS 1256
            ||.|:|||           |..||.:..||||||.||:|||||||::|:|::|.|||||.|||
Mouse  1104 LAFLNEYFGIGRVSFGAFLDVAFITTVTFLWKVSAITVVSCLPLYVLKYLKRKLSPPSYSKLS 1166

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31729	NP_609634.1	PhoLip_ATPase_N	227..279	CDD:292826	32/51 (63%)
		ATPase-Plipid	228..1252	CDD:273734	662/1060 (62%)
		E1-E2_ATPase	323..525	CDD:278548	124/224 (55%)
		Cation_ATPase	<704..783	CDD:289987	54/78 (69%)
		HAD_like	<975..1019	CDD:304363	31/43 (72%)
		PhoLip_ATPase_C	1021..1249	CDD:292829	166/238 (70%)
Atp9b	XP_006526569.1	P-type_ATPase_APLT_Neo1-like	131..1076	CDD:319841	612/972 (63%)
Atp9b	XP_006526569.1	Cation_ATPase	596..680	CDD:372530	56/88 (64%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167834998
Domainoid	1	1.000	342	1.000	Domainoid score	I1071
eggNOG	1	0.900	-	-		E1_KOG0210
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H21915
Inparanoid	1	1.050	1309	1.000	Inparanoid score	I154
Isobase	1	0.950	-	0	Normalized mean entropy	S481
OMA	1	1.010	-	-		QHG53737
OrthoDB	1	1.010	-	-		D587717at2759
OrthoFinder	1	1.000	-	-		FOG0002153
OrthoInspector	1	1.000	-	-		otm43588
orthoMCL	1	0.900	-	-		OOG6_101160
Panther	1	1.100	-	-	LDO	PTHR24092
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5489
SonicParanoid	1	1.000	-	-		X1437
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	18	17.750