Protein Alignment CG31729 and Atp11a

DIOPT Version :10

• Sequence 1: NP_609634.1
• Gene: CG31729 / 34736
• FlyBaseID: FBgn0051729
• Length: 1256
• Species: Drosophila melanogaster
• Sequence 2: NP_056619.1
• Gene: Atp11a / 50770
• MGIID: 1354735
• Length: 1187
• Species: Mus musculus
• Alignment Length: 1153
• Identity: 350/1153 - (30%)
• Similarity: 561/1153 - (48%)
• Gaps: 200/1153 - (17%)

  Fly   201 CSCWRKWFRPRELRARTVNLGRVN---------TEKFPPNEIRNQKYNFITFLPLVLFEQFRFFL 256
            |:....|     :.:||:.:|...         .:::|.|.|.:.||.|..|:|..||||||...
Mouse    14 CAGEENW-----VDSRTIYVGHKEPPPGAEAYIPQRYPDNRIVSSKYTFWNFIPKNLFEQFRRIA 73

  Fly   257 NLYFLLMALSQFIPDIRIGYPYTYWGPLGFVLMVTICREAVDDLRRHQRDHEVNSQKYKRLSSTN 321
            |.|||::.|.|.|.|.... |.|...||.||:.||..::..:|..||:.|:.:|......:....
Mouse    74 NFYFLIIFLVQLIIDTPTS-PVTSGLPLFFVITVTAIKQGYEDWLRHKADNAMNQCPVHFIQHGK 137

  Fly   322 ISGYEMVPSSKLKVGDVIIVEKNERVPADLILLRTSDRSGSVFVRTDQLDGETDWKPRLAVPYTQ 386
            :...:   |.||:|||:::|:::|..|.|||.|.::...|:..|.|..||||:..|...||..|:
Mouse   138 LVRKQ---SRKLRVGDIVMVKEDETFPCDLIFLSSNRADGTCHVTTASLDGESSHKTHYAVQDTK 199

  Fly   387 KLSRDSELHSIDASFYVEKPQNDIHSFIATFCMAD----------GSED---TGLSVENTLWANT 438
            ....::::.|:.|:...|:||.|::.|:....:.:          |||:   .|.:::||
Mouse   200 GFHTEADVDSLHATIECEQPQPDLYKFVGRINVYNDLNDPVVRPLGSENLLLRGATLKNT----- 259

  Fly   439 VVAAGTATGIVIYTGCETRSVMNNSQPRSKVGLLDMEINGLTKVLFCAVLGLSLVMMMLKGF--- 500
                ....|:.||||.||:..:|......|...::..:|....|..|.::..:|:..:||..
Mouse   260 ----EKIFGVAIYTGMETKMALNYQSKSQKRSAVEKSMNTFLIVYLCILVSKALINTVLKYVWQS 320

  Fly   501 ----GGPWY---------RYMF--------RFVLLFSYIIPISLRVNLDM----GKAFYSW--QM 538
                ..|||         |.:|        .|::||:||||:|:.|.::|    |..|.:|  .|
Mouse   321 EPFRDEPWYNEKTESERQRNLFLRAFTDFLAFMVLFNYIIPVSMYVTVEMQKFLGSYFITWDEDM 385

  Fly   539 QNDSNIQGTVVRSTTIPEELGRISYVLTDKTGTLTQNEMVFKKIHL-GIVSHDADTFHHIGQMIQ 602
            .::...:|.:|.::.:.||||::.|:.||||||||:|.|.||:..: |.|        ::..:|
Mouse   386 FDEEMGEGPLVNTSDLNEELGQVEYIFTDKTGTLTENNMAFKECCIEGHV--------YVPHVI- 441

  Fly   603 KLSGNILQQQQG-SLSSSSSG--GDSTKPMMFGNRMRRPEGWREWEAVRALALCHNVTPVSDDED 664
             .:|.:|....| .:..||.|  |...:.:.|                ||:.|||.| .|.||.
Mouse   442 -CNGQVLPDSSGIDMIDSSPGVCGREREELFF----------------RAICLCHTV-QVKDDH- 487

  Fly   665 NRSVSTASTVTGGNNSP-TKSVINIEAPGSTDTEHQYQAASPDEIALVKWTEQVGLTLIARDLNT 728
                 ....|.|...|| .||.:             |.::||||:|||:..:::|.|.:....|.
Mouse   488 -----CGDDVDGPQKSPDAKSCV-------------YISSSPDEVALVEGVQRLGFTYLRLKDNY 534

  Fly   729 MTLQVKTPSEDNDILLHYQILQLFPFTSESKRMGIIVRESKTGQITFYLKGAD------VVMSSI 787
            |.:.    :.:||| ..:::|::..|.|..:||.:||: |.||:|..:.||||      |:...:
Mouse   535 MEIL----NRENDI-ERFELLEVLTFDSVRRRMSVIVK-STTGEIYLFCKGADSSIFPRVIEGKV 593

  Fly   788 VQYNDWLSEESGNMAREGLRTLVVAKKVLTEEQYSDFETRYNAARLSITDRVAKVAAVTESLERE 852
            .|....:...    |.||||||.||.|.|..|||.|......:|::::.||..|:|...|.:|::
Mouse   594 DQVRSRVERN----AVEGLRTLCVAYKRLEPEQYEDACRLLQSAKVALQDREKKLAEAYEQIEKD 654

  Fly   853 LELLCLTGVEDRLQENVRPTLELLRNAGVRVWMLTGDKLET--ACCIA-----KSSQLIG----- 905
            |.||..|.|||||||....|:|.|:.||::||:|||||:||  |.|.|     :|:||:.
Mouse   655 LVLLGATAVEDRLQEKAADTIEALQKAGIKVWVLTGDKMETASATCYACKLFRRSTQLLELTTKK 719

  Fly   906 -RNQGLH---------VLRSVKTRT-DAHQELNSFRRKQGHALVISGESLEVCLQ---------Y 950
             ..|.||         |||...:.| |:...|::.....|  |:|.|.:|.:.::         .
Mouse   720 LEEQSLHDVLFDLSKTVLRCSGSMTRDSFSGLSTDMHDYG--LIIDGAALSLIMKPREDGSSSGN 782

  Fly   951 YRPEFLELATASPAVVCCRCSPTQKAQVVALI---QKHTGKRTCAVGDGGNDVSMIQQADAGVGI 1012
            ||..|||:.....||:|||.:|.||||:|.||   ::|  ..|.|:|||.||||||.:|..|:|:
Mouse   783 YRELFLEICRNCSAVLCCRMAPLQKAQIVKLIKFSKEH--PITLAIGDGANDVSMILEAHVGIGV 845

  Fly  1013 EGREGRQASLAGDFSIPQFSHIAKLLLIHGRRSYKRSAALSQFVIHRGLIITTLQAVFSAVFYLS 1077
            .|:|||||:...|::||:|.|:.|:||:||...|.|.:.|.|:..::.:.....|.::......|
Mouse   846 IGKEGRQAARNSDYAIPKFKHLKKMLLVHGHFYYIRISELVQYFFYKNVCFIFPQFLYQFFCGFS 910

  Fly  1078 SVALYQGFLMVGYSTLYTMFPV--FSLVLDQDITSETAVTYPELYKDLSKGRSLSYKTFFIWVLI 1140
            ...||....:..|:..:|..|:  :|| ::|.:..:.....|.||:|::|...|.::.|..|..:
Mouse   911 QQTLYDTAYLTLYNISFTSLPILLYSL-MEQHVGIDVLKRDPTLYRDIAKNALLRWRVFIYWTFL 974

  Fly  1141 SIYQGGVIMYGALILFVDEFIHI----------VAISFSALIMTELIMVALTVRTW----HRLMV 1191
            .::...|..:||..:|.:..:.|          ..:.|:.:::|..:.:||....|    |.::.
Mouse   975 GVFDALVFFFGAYFIFENTTVTINGQMFGNWTFGTLVFTVMVLTVTLKLALDTHYWTWINHFVIW 1039

  Fly  1192 LAELFSLALYLISLAVLHEYFDWEFIWSYDFLWKVSLITLVSCLPLYI 1239
            .:.||.:|..|:...|:     |.|: ||..::.| .|:::|..|.::
Mouse  1040 GSLLFYIAFSLLWGGVI-----WPFL-SYQRMYYV-FISMLSSGPAWL 1080

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG31729	NP_609634.1	P-type_ATPase_APLT_Neo1-like	230..1177	CDD:319841	327/1047 (31%)
		Cation_ATPase	<704..781	CDD:463817	27/76 (36%)
Atp11a	NP_056619.1	P-type_ATPase_APLT_Dnf-like	47..986	CDD:319770	321/1012 (32%)
		MelB	<955..>1095	CDD:441813	29/133 (22%)