DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG31729 and Atp8a2

DIOPT Version :9

Sequence 1:	NP_609634.1	Gene:	CG31729 / 34736	FlyBaseID:	FBgn0051729	Length:	1256	Species:	Drosophila melanogaster
Sequence 2:	NP_056618.1	Gene:	Atp8a2 / 50769	MGIID:	1354710	Length:	1148	Species:	Mus musculus

Alignment Length:	1115	Identity:	318/1115 - (28%)
Similarity:	522/1115 - (46%)	Gaps:	174/1115 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   212 ELRARTVNLGRVNTEKFPPNEIRNQKYNFITFLPLVLFEQFRFFLNLYFLLMALSQFIPDIRIGY 276
            |..||.:.|.:.:..||..|.|...||:.:||||..|:||.|...|.:||.:||.|.|||:....
Mouse    12 EAPARIIYLNQSHLNKFCDNRISTAKYSVLTFLPRFLYEQIRRAANAFFLFIALLQQIPDVSPTG 76

  Fly   277 PYTYWGPLGFVLMVTICREAVDDLRRHQRDHEVNSQKYKRLSSTNISGYEMVPSSKLKVGDVIIV 341
            .||...||..:|.:...:|.::|.:||:.|:.||.:|...|.:   ..:..:...::.|||::.|
Mouse    77 RYTTLVPLVIILTIAGIKEIIEDFKRHKADNAVNKKKTIVLRN---GMWHTIMWKEVAVGDIVKV 138

  Fly   342 EKNERVPADLILLRTSDRSGSVFVRTDQLDGETDWKPRLAVPYTQKLSRDSELHSIDASFYVEKP 406
            ...:.:|||::|..:|:..|..:|.|..|||||:.|.|..:.:|..:.....|..:......|.|
Mouse   139 LNGQYLPADMVLFSSSEPQGMCYVETANLDGETNLKIRQGLSHTTDMQTRDVLMKLSGRIECEGP 203

  Fly   407 QNDIHSFIATFCMADGSEDT----------GLSVENTLWANTVVAAGTATGIVIYTGCETRSVMN 461
            ...::.|.....: ||....          |..:.||.|         ..|:|:|||.::: :|.
Mouse   204 NRHLYDFTGNLHL-DGKSSVALGPDQILLRGTQLRNTQW---------VFGVVVYTGHDSK-LMQ 257

  Fly   462 NSQPRSKVGLLDMEINGLTKVLFCAVLGLSLVMMMLKGFGG----------PWY----------- 505
            ||   :|..|....:..:|.|....:.|:.|||.::...|.          .||
Mouse   258 NS---TKAPLKRSNVEKVTNVQILVLFGILLVMALVSSVGALFWNGSHGGKSWYIKKMDTNSDNF 319

  Fly   506 -RYMFRFVLLFSYIIPISLRVNLDMGK----AFYSWQM-----QNDSNIQGTVVRSTTIPEELGR 560
             ..:..|::|::.:|||||.|.|::.|    .|.:|.|     :||:   ..:.|::.:.||||:
Mouse   320 GYNLLTFIILYNNLIPISLLVTLEVVKYTQALFINWDMDMYYIENDT---PAMARTSNLNEELGQ 381

  Fly   561 ISYVLTDKTGTLTQNEMVFKKIHLGIVSHDADTFHHIGQMIQKLSGNILQQQQGSLSSSSSGGDS 625
            :.|:.:|||||||.|.|.|||..:..|     |:.|..::.::.|.:...:.   .|.::...|.
Mouse   382 VKYLFSDKTGTLTCNIMNFKKCSIAGV-----TYGHFPELAREQSSDDFCRM---TSCTNDSCDF 438

  Fly   626 TKPMMFGN-RMRRPEGWREWEAVRALALCHNVTPVSDDEDNRSVSTASTVTGGNNSPTKSVINIE 689
            ..|.:..| ..:.|......|.:..||:||.|.|..|.::                    :|
Mouse   439 NDPRLLKNIEDQHPTAPCIQEFLTLLAVCHTVVPEKDGDE--------------------II--- 480

  Fly   690 APGSTDTEHQYQAASPDEIALVKWTEQVGLTLIARDLNTMTLQVKTPSEDNDILLHYQILQLFPF 754
                      |||:||||.||||..:::|.....|...::.::.....:.      :.||.:..|
Mouse   481 ----------YQASSPDEAALVKGAKKLGFVFTGRTPYSVIIEAMGQEQT------FGILNVLEF 529

  Fly   755 TSESKRMGIIVRESKTGQITFYLKGAD-VVMSSIVQYNDWLSEESGNM---AREGLRTLVVAKKV 815
            :|:.|||.:||| ..:||:..|.|||| |:...:.:.:.::.|...::   |.||||||.||...
Mouse   530 SSDRKRMSVIVR-LPSGQLRLYCKGADNVIFERLSKDSKYMEETLCHLEYFATEGLRTLCVAYAD 593

  Fly   816 LTEEQYSDFETRYNAARLSITDRVAKVAAVTESLERELELLCLTGVEDRLQENVRPTLELLRNAG 880
            |:|.:|.::...|..|.:.:.||..::....|.:|:.|.||..|.:|||||..|..|:..|..|.
Mouse   594 LSENEYEEWLKVYQEASIILKDRAQRLEECYEIIEKNLLLLGATAIEDRLQAGVPETIATLLKAE 658

  Fly   881 VRVWMLTGDKLETACCIAKSSQLIGRNQGLHVLRSVK---TRTDAHQEL----NSFRRKQGHALV 938
            :::|:|||||.|||..|..|.:|:.:|..|.:|:...   ||....|..    |...::...||:
Mouse   659 IKIWVLTGDKQETAINIGYSCRLVSQNMALILLKEDSLDATRAAITQHCTDLGNLLGKENDVALI 723

  Fly   939 ISGESLEVCLQY-YRPEFLELATASPAVVCCRCSPTQKAQVVALIQKHTGKRTCAVGDGGNDVSM 1002
            |.|.:|:..|.: .|..||:||.:..||:|||.||.||:::|.:::|.....|.|:|||.|||.|
Mouse   724 IDGHTLKYALSFEVRRSFLDLALSCKAVICCRVSPLQKSEIVDVVKKRVKAITLAIGDGANDVGM 788

  Fly  1003 IQQADAGVGIEGREGRQASLAGDFSIPQFSHIAKLLLIHGRRSYKRSAALSQFVIHRGLIITTLQ 1067
            ||.|..||||.|.||.||:...|::|.|||::.||||:||..||.|......:..::.:::..::
Mouse   789 IQTAHVGVGISGNEGMQATNNSDYAIAQFSYLEKLLLVHGAWSYNRVTKCILYCFYKNVVLYIIE 853

  Fly  1068 AVFSAVFYLSSVALYQGFLMVGYSTLYTMFPVFSL-VLDQDITSETAVTYPELYKDLSKGRSLSY 1131
            ..|:.|...|...|::.:.:..|:.::|..|.|:| :.::..|.|:.:.:|:||:........:.
Mouse   854 LWFAFVNGFSGQILFERWCIGLYNVIFTALPPFTLGIFERSCTQESMLRFPQLYRITQNAEGFNT 918

  Fly  1132 KTFFIWVLISIYQGGVI--MYGALILF-----------------VDEFIHIVAISFSALIMTELI 1177
            |.|  |       |..|  :..:||||                 ..:::.:..|.::.:::|..:
Mouse   919 KVF--W-------GHCINALVHSLILFWVPMKALEHDTPVTSGHATDYLFVGNIVYTYVVVTVCL 974

  Fly  1178 MVALTVRTWHRLMVLAELFSLALYLISLAVLHEYFDWEFIW-----------------SYDFLWK 1225
            ...|....|.:...||...|:.::|:...|      :..||                 |..:.|.
Mouse   975 KAGLETTAWTKFSHLAVWGSMLIWLVFFGV------YSTIWPTIPIAPDMKGQATMVLSSAYFWL 1033

  Fly  1226 VSLITLVSCL 1235
            ...:...:||
Mouse  1034 GLFLVPTACL 1043

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31729	NP_609634.1	PhoLip_ATPase_N	227..279	CDD:292826	23/51 (45%)
		ATPase-Plipid	228..1252	CDD:273734	313/1099 (28%)
		E1-E2_ATPase	323..525	CDD:278548	56/233 (24%)
		Cation_ATPase	<704..783	CDD:289987	27/79 (34%)
		HAD_like	<975..1019	CDD:304363	22/43 (51%)
		PhoLip_ATPase_C	1021..1249	CDD:292829	52/252 (21%)
Atp8a2	NP_056618.1	PhoLip_ATPase_N	17..79	CDD:292826	24/61 (39%)
		ATPase-Plipid	28..1066	CDD:273734	313/1099 (28%)
		E1-E2_ATPase	85..>170	CDD:278548	24/87 (28%)
		Cation_ATPase	466..564	CDD:289987	37/137 (27%)
		HAD_like	<776..805	CDD:304363	19/28 (68%)
		PhoLip_ATPase_C	808..1059	CDD:292829	52/251 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53737
OrthoDB	1	1.010	-	-		D587717at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.930