DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG31729 and ATP9B

DIOPT Version :9

Sequence 1:	NP_609634.1	Gene:	CG31729 / 34736	FlyBaseID:	FBgn0051729	Length:	1256	Species:	Drosophila melanogaster
Sequence 2:	XP_011524265.1	Gene:	ATP9B / 374868	HGNCID:	13541	Length:	1174	Species:	Homo sapiens

Alignment Length:	1119	Identity:	686/1119 - (61%)
Similarity:	833/1119 - (74%)	Gaps:	91/1119 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly   195 VCK----LCLCSCWRKWF-----RPRELRARTVNLG--RVNTEKFPPNEIRNQKYNFITFLPLVL 248
            ||.    ||...|  .|.     |.:||:||||.||  ....||.|.|.|:|||||..||:|.||
Human    89 VCDGWKFLCTSCC--GWLINICRRKKELKARTVWLGCPEKCEEKHPRNSIKNQKYNVFTFIPGVL 151

  Fly   249 FEQFRFFLNLYFLLMALSQFIPDIRIGYPYTYWGPLGFVLMVTICREAVDDLRRHQRDHEVNSQK 313
            :|||:||||||||:::.|||:|.::|||.||||.||||||.||:.|||:|:.||.|||.|||||.
Human   152 YEQFKFFLNLYFLVISCSQFVPALKIGYLYTYWAPLGFVLAVTMTREAIDEFRRFQRDKEVNSQL 216

  Fly   314 YKRLSSTNISGYEMVPSSKLKVGDVIIVEKNERVPADLILLRTSDRSGSVFVRTDQLDGETDWKP 378
            |.:|:   :.|...|.||.::|||:||||||:|:|:|::.||||:::||.|:||||||||||||.
Human   217 YSKLT---VRGKVQVKSSDIQVGDLIIVEKNQRIPSDMVFLRTSEKAGSCFIRTDQLDGETDWKL 278

  Fly   379 RLAVPYTQKLSRDSELHSIDASFYVEKPQNDIHSFIATFCMADGSE--DTGLSVENTLWANTVVA 441
            ::||..||:|....:|.||.|..|.:|||.|||||..||...|...  ...||:||||||:|:||
Human   279 KVAVSCTQQLPALGDLFSISAYVYAQKPQMDIHSFEGTFTREDSDPPIHESLSIENTLWASTIVA 343

  Fly   442 AGTATGIVIYTGCETRSVMNNSQPRSKVGLLDMEINGLTKVLFCAVLGLSLVMMMLKGFGGPWYR 506
            :||..|:|||||.|||||||.|.|::||||||:|:|.|||.||.|::.||:||:.|:||.|||||
Human   344 SGTVIGVVIYTGKETRSVMNTSNPKNKVGLLDLELNRLTKALFLALVALSIVMVTLQGFVGPWYR 408

  Fly   507 YMFRFVLLFSYIIPISLRVNLDMGKAFYSWQMQNDSNIQGTVVRSTTIPEELGRISYVLTDKTGT 571
            .:|||:||||||||||||||||||||.|.|.|..|.||.|||||::||||||||:.|:|||||||
Human   409 NLFRFLLLFSYIIPISLRVNLDMGKAVYGWMMMKDENIPGTVVRTSTIPEELGRLVYLLTDKTGT 473

  Fly   572 LTQNEMVFKKIHLGIVSHDADTFHHIGQMIQKLSGNILQQQQGSLSSSSSGGDST------KPMM 630
            ||||||:||::|||.||:.|||...|...::    :...|.|     |.:||::|      |...
Human   474 LTQNEMIFKRLHLGTVSYGADTMDEIQSHVR----DSYSQMQ-----SQAGGNNTGSTPLRKAQS 529

  Fly   631 FGNRMRRPEGWREWEAVRALALCHNVTPVSDDEDNRSVSTASTVTGGNNSPTKSVINIEAPGS-T 694
            ...::|:....|..|||:|:.||||||||   .::|:..|..|...            ||... :
Human   530 SAPKVRKSVSSRIHEAVKAIVLCHNVTPV---YESRAGVTEETEFA------------EADQDFS 579

  Fly   695 DTEHQYQAASPDEIALVKWTEQVGLTLIARDLNTMTLQVKTPSEDNDILLHYQILQLFPFTSESK 759
            |....|||:||||:|||:|||.|||||::|||.:|  |:||||..   :|.:.||||||||||||
Human   580 DENRTYQASSPDEVALVQWTESVGLTLVSRDLTSM--QLKTPSGQ---VLSFCILQLFPFTSESK 639

  Fly   760 RMGIIVRESKTGQITFYLKGADVVMSSIVQYNDWLSEESGNMAREGLRTLVVAKKVLTEEQYSDF 824
            |||:|||:..|.:||||:|||||.||.||||||||.||.||||||||||||||||.||||||.||
Human   640 RMGVIVRDESTAEITFYMKGADVAMSPIVQYNDWLEEECGNMAREGLRTLVVAKKALTEEQYQDF 704

  Fly   825 E--------------------------TRYNAARLSITDRVAKVAAVTESLERELELLCLTGVED 863
            |                          :||..|:||:.||..|||||.||||||:||||||||||
Human   705 EPMQSSSVESTHSTYTCAHRRLPLCPQSRYTQAKLSMHDRSLKVAAVVESLEREMELLCLTGVED 769

  Fly   864 RLQENVRPTLELLRNAGVRVWMLTGDKLETACCIAKSSQLIGRNQGLHVLRSVKTRTDAHQELNS 928
            :||.:||||||:|||||:::|||||||||||.||||||.|:.|.|.:|:.|.|.:|.:||.|||:
Human   770 QLQADVRPTLEMLRNAGIKIWMLTGDKLETATCIAKSSHLVSRTQDIHIFRQVTSRGEAHLELNA 834

  Fly   929 FRRKQGHALVISGESLEVCLQYYRPEFLELATASPAVVCCRCSPTQKAQVVALIQKHTGKRTCAV 993
            ||||...||||||:||||||:||..||:|||...||||||||||||||::|.|:|:|||:||||:
Human   835 FRRKHDCALVISGDSLEVCLKYYEHEFVELACQCPAVVCCRCSPTQKARIVTLLQQHTGRRTCAI 899

  Fly   994 GDGGNDVSMIQQADAGVGIEGREGRQASLAGDFSIPQFSHIAKLLLIHGRRSYKRSAALSQFVIH 1058
            |||||||||||.||.|:||||:||:|||||.||||.||.||.:||::|||.||||||||.|||:|
Human   900 GDGGNDVSMIQAADCGIGIEGKEGKQASLAADFSITQFRHIGRLLMVHGRNSYKRSAALGQFVMH 964

  Fly  1059 RGLIITTLQAVFSAVFYLSSVALYQGFLMVGYSTLYTMFPVFSLVLDQDITSETAVTYPELYKDL 1123
            |||||:|:|||||:|||.:||.||||||||||:|:||||||||||||||:..|.|:.||||||||
Human   965 RGLIISTMQAVFSSVFYFASVPLYQGFLMVGYATIYTMFPVFSLVLDQDVKPEMAMLYPELYKDL 1029

  Fly  1124 SKGRSLSYKTFFIWVLISIYQGGVIMYGALILFVDEFIHIVAISFSALIMTELIMVALTVRTWHR 1188
            :||||||:|||.|||||||||||::|||||:||..||:|:|||||:|||:|||:||||||||||.
Human  1030 TKGRSLSFKTFLIWVLISIYQGGILMYGALVLFESEFVHVVAISFTALILTELLMVALTVRTWHW 1094

  Fly  1189 LMVLAELFSLALYLISLAVLHEYF-----------DWEFIWSYDFLWKVSLITLVSCLPLYIIKF 1242
            |||:||..||..|:.|||.|:|||           |..||.:..||||||.||:|||||||::|:
Human  1095 LMVVAEFLSLGCYVSSLAFLNEYFGIGRVSFGAFLDVAFITTVTFLWKVSAITVVSCLPLYVLKY 1159

  Fly  1243 LRKKCSPPSYLKLS 1256
            ||:|.|||||.||:
Human  1160 LRRKLSPPSYCKLA 1173

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31729	NP_609634.1	PhoLip_ATPase_N	227..279	CDD:292826	32/51 (63%)
		ATPase-Plipid	228..1252	CDD:273734	665/1069 (62%)
		E1-E2_ATPase	323..525	CDD:278548	124/203 (61%)
		Cation_ATPase	<704..783	CDD:289987	52/78 (67%)
		HAD_like	<975..1019	CDD:304363	32/43 (74%)
		PhoLip_ATPase_C	1021..1249	CDD:292829	167/238 (70%)
ATP9B	XP_011524265.1	PhoLip_ATPase_N	125..182	CDD:292826	33/56 (59%)
		ATPase-Plipid	132..1169	CDD:273734	665/1068 (62%)
		E1-E2_ATPase	224..427	CDD:278548	124/202 (61%)
		Cation_ATPase	579..661	CDD:289987	54/86 (63%)
		HAD_like	<881..922	CDD:304363	30/40 (75%)
		PhoLip_ATPase_C	927..1166	CDD:292829	167/238 (70%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165144891
Domainoid	1	1.000	351	1.000	Domainoid score	I1018
eggNOG	1	0.900	-	-		E1_KOG0210
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H21915
Inparanoid	1	1.050	1318	1.000	Inparanoid score	I151
Isobase	1	0.950	-	0	Normalized mean entropy	S481
OMA	1	1.010	-	-		QHG53737
OrthoDB	1	1.010	-	-		D587717at2759
OrthoFinder	1	1.000	-	-		FOG0002153
OrthoInspector	1	1.000	-	-		otm41538
orthoMCL	1	0.900	-	-		OOG6_101160
Panther	1	1.100	-	-	LDO	PTHR24092
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1437
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	16	15.720