DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG31729 and Atp11c

DIOPT Version :9

Sequence 1:	NP_609634.1	Gene:	CG31729 / 34736	FlyBaseID:	FBgn0051729	Length:	1256	Species:	Drosophila melanogaster
Sequence 2:	XP_006257661.1	Gene:	Atp11c / 317599	RGDID:	1564481	Length:	1130	Species:	Rattus norvegicus

Alignment Length:	1170	Identity:	345/1170 - (29%)
Similarity:	521/1170 - (44%)	Gaps:	225/1170 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   211 RELRARTVNLGR---VNTE-----KFPPNEIRNQKYNFITFLPLVLFEQFRFFLNLYFLLMALSQ 267
            :.:..|||.:|.   ..||     :|..|.|.:.||....|||..||||||...|.|||::.|.|
  Rat    16 KRVGTRTVFVGNHPISGTEAYIAQRFCDNRIVSSKYTLWNFLPKNLFEQFRRIANFYFLIIFLVQ 80

  Fly   268 FIPDIRIGYPYTYWGPLGFVLMVTICREAVDDLRRHQRDHEVNS------QKYKRLSSTNISGYE 326
            ...|.... |.|...||.||:.||..::..:|..||:.|:|||.      :..||:..
  Rat    81 VTVDTPTS-PVTSGLPLFFVITVTAIKQGYEDWLRHRADNEVNKSTVYIIENAKRVRK------- 137

  Fly   327 MVPSSKLKVGDVIIVEKNERVPADLILLRTSDRSGSVFVRTDQLDGETDWKPRLAVPYTQKLSRD 391
              .|.|:|||||:.|:.:|..|.|||||.:....|:.:|.|..||||::.|...||..|.:|...
  Rat   138 --ESEKIKVGDVVEVQADETFPCDLILLSSCTTDGTCYVTTASLDGESNCKTHYAVRDTIELCTA 200

  Fly   392 SELHSIDASFYVEKPQNDIHSFIATFCMADGSEDT---GLSVENTLWAN-TVVAAGTATGIVIYT 452
            ..:.::.|:...|:||.|::.|:....:...|.:.   .|..||.|... |:.......|:.:||
  Rat   201 ESIDNLRAAIECEQPQPDLYKFVGRISIYSNSIEAVARSLGPENLLLKGATLKNTKKIYGVAVYT 265

  Fly   453 GCETRSVMN---NSQPRSKVGLLDMEING---------LTKVLFCAVLGLSLVMMMLKGFGGPWY 505
            |.||:..:|   .||.||.|   :..||.         |||...|..  |..|.........|||
  Rat   266 GMETKMALNYQGKSQKRSAV---EKSINAFLIVYLFILLTKAAVCTT--LKYVWQSTPYNDEPWY 325

  Fly   506 -------RYMFR----------FVLLFSYIIPISLRVNLDM----GKAFYSWQMQ-NDSNI-QGT 547
                   |..|:          |::||::|||:|:.|.::|    |..|.||... .|..| :|.
  Rat   326 NQKTQKERETFKVLKMFTDFLSFMVLFNFIIPVSMYVTVEMQKFLGSFFISWDKDFFDEEINEGA 390

  Fly   548 VVRSTTIPEELGRISYVLTDKTGTLTQNEMVFKKIHLGIVSHDADTFHHIGQMIQKLSGNILQQQ 612
            :|.::.:.||||::.||.||||||||:|.|.|.:..:....:...|        |::.|  |.|.
  Rat   391 LVNTSDLNEELGQVDYVFTDKTGTLTENSMEFIECCIDGHKYKGTT--------QEVDG--LSQI 445

  Fly   613 QGSLSSSSSGGDSTKPMMFGNRMRRPEGWREWEAVRALALCHNVTPVSDDEDNRSVSTASTVTGG 677
            .|.|:.... .|..:..:|               :|||.|||.|          .:.|...|.|
  Rat   446 DGPLAYFDK-ADKNREELF---------------LRALCLCHTV----------EIKTNDAVDG- 483

  Fly   678 NNSPTKSVINIEAPGSTDTEHQYQAASPDEIALVKWTEQVGLTLIARDLNTMTLQVKTPSEDNDI 742
                     .||.     .:..|.::|||||||||..::.|.|.    |......::..::..:|
  Rat   484 ---------PIEG-----AQFTYISSSPDEIALVKGAQKFGFTF----LGNWNGHIRVENQRKEI 530

  Fly   743 LLHYQILQLFPFTSESKRMGIIVRESKTGQITFYLKGADVVMSSI---------------VQYND 792
             ..|::|....|.|..:||.:||| ::.|.|..:.||||   |||               |:.|
  Rat   531 -EEYELLHTLNFDSVRRRMSVIVR-TQGGDILLFCKGAD---SSIFPRVHSHEIDLTKVHVERN- 589

  Fly   793 WLSEESGNMAREGLRTLVVAKKVLTEEQYSDFETRYNAARLSITDRVAKVAAVTESLERELELLC 857
                     |.:|.|||.||.|.:..:.:.....:...|::::.||..|:..:.:.:|..:.|:.
  Rat   590 ---------AMDGYRTLCVAFKEIPPDDFERINVQLIEAKMALQDREEKLEKIFDVIETNMNLIG 645

  Fly   858 LTGVEDRLQENVRPTLELLRNAGVRVWMLTGDKLETACCIAKSSQLIGRNQGLHVLRSVKTRTDA 922
            .|.|||:||:....|:|.|..||::||:|||||:|||.....:.:|...|..|..| :.||..::
  Rat   646 ATAVEDKLQDQAAETIEALHAAGLKVWVLTGDKMETAKSTCYACRLFQTNTELLEL-TTKTIEES 709

  Fly   923 -------HQELNSFRRK-------------------QGHALVISGESLEVCL--------QYYRP 953
                   |:.|..:|:|                   |.:.|:|.|.:|.:.|        ..|:.
  Rat   710 ERKEDRLHELLIEYRKKLLHEFPKSTRSLKKAWTEHQEYGLIIDGSTLSLILNSSQDCSSNNYKS 774

  Fly   954 EFLELATASPAVVCCRCSPTQKAQVVALIQKHTGKR-TCAVGDGGNDVSMIQQADAGVGIEGREG 1017
            .||::.....||:|||.:|.||||:|.:::...|.. |.::|||.||||||.::..|:||:|:||
  Rat   775 IFLQICMKCTAVLCCRMAPLQKAQIVRMVKNLKGSPITLSIGDGANDVSMILESHVGIGIKGKEG 839

  Fly  1018 RQASLAGDFSIPQFSHIAKLLLIHGRRSYKRSAALSQFVIHRGLIITTLQAVFSAVFYLSSVALY 1082
            |||:...|:|:|:|.|:.||||.||...|.|.|.|.|:..::.|.....|.::......|...||
  Rat   840 RQAARNSDYSVPKFKHLKKLLLAHGHLYYVRIAHLVQYFFYKNLCFILPQFLYQFFCGFSQQPLY 904

  Fly  1083 QGFLMVGYSTLYTMFPVFSL-VLDQDITSETAVTYPELYKDLSKGRSLSYKTFFIWVLISIYQGG 1146
            ....:..|:..:|..|:.:. :|:|.|..:.....|.||..::....|....|..|..::.::|.
  Rat   905 DAAYLTMYNICFTSLPILAYSLLEQHINIDALTADPRLYMKITGNAMLQLGPFLYWTFLAAFEGT 969

  Fly  1147 VIMYGALILFVDEFIH----------IVAISFSALIMTELIMVALTVRTWHRLMVLAELFSLALY 1201
            |..:|...||....:.          ...|.|:.|:.|..:.:||..|.|..:.......|||.|
  Rat   970 VFFFGTYFLFQTTSLEDNGKIYGNWTFGTIVFTVLVFTVTLKLALDTRFWTWINHFVIWGSLAFY 1034

  Fly  1202 LISLAVLHEYFDWEFIWSY-----------DFLWKVS------LITLVSCLP---LYIIKFLRKK 1246
                 |...:|....||.:           ..|..||      |:..:|..|   |.::|.:|::
  Rat  1035 -----VFFSFFWGGIIWPFLKQQRMYFVFAQMLSSVSTWLAIILLIFISLFPEILLIVVKNVRRR 1094

Fly 1247 1246
Rat 1095 1094

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31729	NP_609634.1	PhoLip_ATPase_N	227..279	CDD:292826	22/51 (43%)
		ATPase-Plipid	228..1252	CDD:273734	339/1145 (30%)
		E1-E2_ATPase	323..525	CDD:278548	71/234 (30%)
		Cation_ATPase	<704..783	CDD:289987	28/78 (36%)
		HAD_like	<975..1019	CDD:304363	21/44 (48%)
		PhoLip_ATPase_C	1021..1249	CDD:292829	63/257 (25%)
Atp11c	XP_006257661.1	PhoLip_ATPase_N	38..91	CDD:292826	22/53 (42%)
		ATPase-Plipid	41..1089	CDD:273734	337/1138 (30%)
		E1-E2_ATPase	98..>183	CDD:278548	34/93 (37%)
		Cation_ATPase	469..573	CDD:289987	41/137 (30%)
		HAD_like	<812..841	CDD:304363	16/28 (57%)
		PhoLip_ATPase_C	863..1090	CDD:292829	52/231 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166338590
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D587717at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.850