Protein Alignment CG31729 and ATP11C

DIOPT Version :10

• Sequence 1: NP_609634.1
• Gene: CG31729 / 34736
• FlyBaseID: FBgn0051729
• Length: 1256
• Species: Drosophila melanogaster
• Sequence 2: XP_047297972.1
• Gene: ATP11C / 286410
• HGNCID: 13554
• Length: 1153
• Species: Homo sapiens
• Alignment Length: 1157
• Identity: 343/1157 - (29%)
• Similarity: 518/1157 - (44%)
• Gaps: 199/1157 - (17%)

  Fly   211 RELRARTVNLGR---VNTE-----KFPPNEIRNQKYNFITFLPLVLFEQFRFFLNLYFLLMALSQ 267
            :.:..|||.:|.   ..||     :|..|.|.:.||....|||..||||||...|.|||::.|.|
Human    39 KRVGTRTVFVGNHPVSETEAYIAQRFCDNRIVSSKYTLWNFLPKNLFEQFRRIANFYFLIIFLVQ 103

  Fly   268 FIPDIRIGYPYTYWGPLGFVLMVTICREAVDDLRRHQRDHEVNS------QKYKRLSSTNISGYE 326
            ...|.... |.|...||.||:.||..::..:|..||:.|:|||.      :..||:..
Human   104 VTVDTPTS-PVTSGLPLFFVITVTAIKQGYEDCLRHRADNEVNKSTVYIIENAKRVRK------- 160

  Fly   327 MVPSSKLKVGDVIIVEKNERVPADLILLRTSDRSGSVFVRTDQLDGETDWKPRLAVPYTQKLSRD 391
              .|.|:|||||:.|:.:|..|.|||||.:....|:.:|.|..||||::.|...||..|..|...
Human   161 --ESEKIKVGDVVEVQADETFPCDLILLSSCTTDGTCYVTTASLDGESNCKTHYAVRDTIALCTA 223

  Fly   392 SELHSIDASFYVEKPQNDIHSFIATFCMADGSEDT---GLSVENTLWAN-TVVAAGTATGIVIYT 452
            ..:.::.|:...|:||.|::.|:....:...|.:.   .|..||.|... |:.......|:.:||
Human   224 ESIDTLRAAIECEQPQPDLYKFVGRINIYSNSLEAVARSLGPENLLLKGATLKNTEKIYGVAVYT 288

  Fly   453 GCETRSVMN---NSQPRSKVGLLDMEING---------LTKVLFCAVLGLSLVMMMLKGFGGPWY 505
            |.||:..:|   .||.||.|   :..||.         |||...|..  |..|.........|||
Human   289 GMETKMALNYQGKSQKRSAV---EKSINAFLIVYLFILLTKAAVCTT--LKYVWQSTPYNDEPWY 348

  Fly   506 RY-------------MF----RFVLLFSYIIPISLRVNLDM----GKAFYSWQMQ-NDSNI-QGT 547
            ..             ||    .|::||::|||:|:.|.::|    |..|.||... .|..| :|.
Human   349 NQKTQKERETLKVLKMFTDFLSFMVLFNFIIPVSMYVTVEMQKFLGSFFISWDKDFYDEEINEGA 413

  Fly   548 VVRSTTIPEELGRISYVLTDKTGTLTQNEMVFKKIHLGIVSHDADTFHHIGQMIQKLSGNILQQQ 612
            :|.::.:.||||::.||.||||||||:|.|.|.:..:     |...:..:.|.:..||     |.
Human   414 LVNTSDLNEELGQVDYVFTDKTGTLTENSMEFIECCI-----DGHKYKGVTQEVDGLS-----QT 468

  Fly   613 QGSLSSSSSGGDSTKPMMFGNRMRRPEGWREWEAVRALALCHNVTPVSDDEDNRSVSTASTVTGG 677
            .|:|:.... .|..:..:|               :|||.|||.|          .:.|...|.|.
Human   469 DGTLTYFDK-VDKNREELF---------------LRALCLCHTV----------EIKTNDAVDGA 507

  Fly   678 NNSPTKSVINIEAPGSTDTEHQYQAASPDEIALVKWTEQVGLTLIARDLNTMTLQVKTPSEDNDI 742
            ..|               .|..|.::|||||||||..::.|.|.:......|.::     .....
Human   508 TES---------------AELTYISSSPDEIALVKGAKRYGFTFLGNRNGYMRVE-----NQRKE 552

  Fly   743 LLHYQILQLFPFTSESKRMGIIVRESKTGQITFYLKGADVVMSSIVQYN--DWLSEESGNMAREG 805
            :..|::|....|.:..:||.:||: ::.|.|..:.||||..:...||.:  :.........|.:|
Human   553 IEEYELLHTLNFDAVRRRMSVIVK-TQEGDILLFCKGADSAVFPRVQNHEIELTKVHVERNAMDG 616

  Fly   806 LRTLVVAKKVLTEEQYSDFETRYNAARLSITDRVAKVAAVTESLERELELLCLTGVEDRLQENVR 870
            .|||.||.|.:..:.|.....:...|::::.||..|:..|.:.:|..:.|:..|.|||:||:...
Human   617 YRTLCVAFKEIAPDDYERINRQLIEAKMALQDREEKMEKVFDDIETNMNLIGATAVEDKLQDQAA 681

  Fly   871 PTLELLRNAGVRVWMLTGDKLETACCIAKSSQLIGRNQGLHVLRSVKTRTDA-------HQELNS 928
            .|:|.|..||::||:|||||:|||.....:.:|...|..|..| :.||..::       |:.|..
Human   682 ETIEALHAAGLKVWVLTGDKMETAKSTCYACRLFQTNTELLEL-TTKTIEESERKEDRLHELLIE 745

  Fly   929 FRRK-------------------QGHALVISGESLEVCL--------QYYRPEFLELATASPAVV 966
            :|:|                   |.:.|:|.|.:|.:.|        ..|:..||::.....||:
Human   746 YRKKLLHEFPKSTRSFKKAWTEHQEYGLIIDGSTLSLILNSSQDSSSNNYKSIFLQICMKCTAVL 810

  Fly   967 CCRCSPTQKAQVVALIQKHTGKR-TCAVGDGGNDVSMIQQADAGVGIEGREGRQASLAGDFSIPQ 1030
            |||.:|.||||:|.:::...|.. |.::|||.||||||.::..|:||:|:|||||:...|:|:|:
Human   811 CCRMAPLQKAQIVRMVKNLKGSPITLSIGDGANDVSMILESHVGIGIKGKEGRQAARNSDYSVPK 875

  Fly  1031 FSHIAKLLLIHGRRSYKRSAALSQFVIHRGLIITTLQAVFSAVFYLSSVALYQGFLMVGYSTLYT 1095
            |.|:.||||.||...|.|.|.|.|:..::.|.....|.::......|...||....:..|:..:|
Human   876 FKHLKKLLLAHGHLYYVRIAHLVQYFFYKNLCFILPQFLYQFFCGFSQQPLYDAAYLTMYNICFT 940

  Fly  1096 MFPVFSL-VLDQDITSETAVTYPELYKDLSKGRSLSYKTFFIWVLISIYQGGVIMYGALILFVDE 1159
            ..|:.:. :|:|.|..:|..:.|.||..:|....|....|..|..::.::|.|..:|...||...
Human   941 SLPILAYSLLEQHINIDTLTSDPRLYMKISGNAMLQLGPFLYWTFLAAFEGTVFFFGTYFLFQTA 1005

  Fly  1160 FIH----------IVAISFSALIMTELIMVALTVRTWHRLMVLAELFSLALYLISLAVLHEYFDW 1214
            .:.          ...|.|:.|:.|..:.:||..|.|..:.......|||.|     |...:|..
Human  1006 SLEENGKVYGNWTFGTIVFTVLVFTVTLKLALDTRFWTWINHFVIWGSLAFY-----VFFSFFWG 1065

  Fly  1215 EFIWSY-----------DFLWKVS------LITLVSCLP---LYIIKFLRKK 1246
            ..||.:           ..|..||      |:..:|..|   |.::|.:|::
Human  1066 GIIWPFLKQQRMYFVFAQMLSSVSTWLAIILLIFISLFPEILLIVLKNVRRR 1117

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG31729	NP_609634.1	P-type_ATPase_APLT_Neo1-like	230..1177	CDD:319841	315/1039 (30%)
		Cation_ATPase	<704..781	CDD:463817	23/76 (30%)
ATP11C	XP_047297972.1	P-type_ATPase_APLT_Dnf-like	66..998	CDD:319770	308/1004 (31%)
		PhoLip_ATPase_C	886..1113	CDD:465071	54/231 (23%)