DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG31729 and SPAC4F10.16c

DIOPT Version :9

Sequence 1:	NP_609634.1	Gene:	CG31729 / 34736	FlyBaseID:	FBgn0051729	Length:	1256	Species:	Drosophila melanogaster
Sequence 2:	NP_594759.1	Gene:	SPAC4F10.16c / 2543523	PomBaseID:	SPAC4F10.16c	Length:	1367	Species:	Schizosaccharomyces pombe

Alignment Length:	1270	Identity:	350/1270 - (27%)
Similarity:	563/1270 - (44%)	Gaps:	335/1270 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   228 FPPNEIRNQKYNFITFLPLVLFEQFRFFLNLYFLLMALSQFIP---DIRIGYPYTYWGPLGFVLM 289
            ||.|:||..||..::|:|..|:.||:...|.:||.:.|.|.||   ...:|..:.   ||..:|:
pombe   128 FPSNKIRTTKYTPVSFIPKNLWNQFKNIANAFFLFVTLLQCIPLFCPEHLGLSFI---PLSVILL 189

  Fly   290 VTICREAVDDLRRHQRDHEVNS----------------------QKYKR---------------- 316
            .|..::.::|.||...|.:.|:                      :|.|:
pombe   190 TTAIKDGIEDYRRCVLDKKFNNTLTWKLVGFNNANALGEHIGLWRKLKKFISHTVADMSYCLKNS 254

  Fly   317 --------LSSTNIS------------------------------------------------GY 325
                    |:..|||                                                .:
pombe   255 GISSGLATLTVDNISHRHSLESDSAFTLSSVSQDSLEIHEIGNSGPSNSFSVIQEQSTGSSNAKF 319

  Fly   326 EMVPSSKLKVGDVIIVEKNERVPADLILLRTSDRSGSVFVRTDQLDGETDWKPRLAVPYTQKLSR 390
            |.|....|.|||::.|..:|.:||||::|.|.:.:|..:|.|..|||||:.|.:.|:..|:...
pombe   320 ERVCRKSLLVGDIVKVLADEAIPADLLILSTENSNGVCYVETKNLDGETNLKDKYALCSTKCCK- 383

  Fly   391 DSELHSIDASFYV--EKPQNDIHSF----IATFCMADGSEDT------------------GLSVE 431
             ||.....|||:|  |:|..|::|.    .|...:...||.|                  |.::.
pombe   384 -SEYRCSAASFWVECEQPHADLYSLNGVVKAPGAVQSPSESTNGRKIHEEPFSISNVLLCGCTLR 447

  Fly   432 NTLWANTVVAAGTATGIVIYTGCETRSVMNNSQPRSKVGLLDMEIN-----------------GL 479
            |:.|         ..|:|:|||.|||...|.....||...:..::|                 |:
pombe   448 NSKW---------VIGLVLYTGSETRIQKNRGLTPSKRSRITRDLNWTIILNFLLLFAMCLFSGV 503

  Fly   480 TKVLFCAVLGLSLVMMMLKGFG-GPWYRY--MFRFVLLFSYIIPISLRVNLDMGKAFYSWQMQND 541
            .:.::.|....:.|..:.|... .|.:..  :|..::||..::||||.:.:|:.::..|:.:.:|
pombe   504 LRSIYSAQNNSARVFELSKNSNTAPAHGIISIFTSLILFQNLVPISLYITMDIVRSIQSYFIFSD 568

  Fly   542 SNIQGTVV------RSTTIPEELGRISYVLTDKTGTLTQNEMVFKKIHLGIV----SHDADTFHH 596
            ..:....:      :|..|.::||:|.|:.:|||||||||.|.|||..:..:    ||:.||
pombe   569 REMYDEKLDCPCSPKSWNISDDLGQIEYIFSDKTGTLTQNIMSFKKCSINGIRYGKSHNEDT--- 630

  Fly   597 IGQMIQK---------LSGNILQQQQGSLSSSSSGGDSTKP-------MMFGNRMRRPEGWREWE 645
               .|:|         ||..:...::..|.:.|. .||..|       ..|.:.::..|.:.:.|
pombe   631 ---CIKKRRNLNYNENLSCKVDLDKKKMLETLSL-SDSPNPESITFISSKFVDHLQSNENYIQTE 691

  Fly   646 A----VRALALCHNVTPVSDDEDNRSVSTASTVTGGNNSPTKSVINIEAPGSTDTEHQYQAASPD 706
            |    .:||||||:|  |:|.:|...:                               |.|.|||
pombe   692 ACFEFFKALALCHSV--VTDVQDETLI-------------------------------YNAQSPD 723

  Fly   707 EIALVKWTEQVGLTLIARDLNTMTLQVKTPSEDNDILLHYQILQLFPFTSESKRMGIIVRESKTG 771
            |.||||.....|.||:.......|::::..::      ::::|.:.||||..|||.:|:|: :.|
pombe   724 EEALVKVARDFGFTLLNTKNRRYTIRIRGENK------NFRVLDIIPFTSTRKRMSVIIRD-EDG 781

  Fly   772 QITFYLKGADVVM--------SSIVQYNDWLSEESGNMAREGLRTLVVAKKVLTEEQYSDFETRY 828
            .|....||||.|:        ::|::..   .:...:.:.||.|||.:|::.:.::.|.:::..:
pombe   782 IIHLICKGADTVIFPRLSSGQNNIIEKT---KKHLASFSSEGFRTLCIARRTIDKQDYLEWKVNF 843

  Fly   829 NAARLSITDRVAKVAAVTESLERELELLCLTGVEDRLQENVRPTLELLRNAGVRVWMLTGDKLET 893
            |.|..:|.:|..||:.|:|.:|:|||||..|.:||:|||||..|:.||..||:::|:|||||:||
pombe   844 NEANSAIHERNEKVSKVSEMIEQELELLGGTAIEDKLQENVPETIALLAIAGIKLWVLTGDKVET 908

  Fly   894 ACCIAKSSQLIGRNQGLHVLRSVKTRTDAH-----QELNSFRR---------------------- 931
            |..|..|..|:..|..:.       |.||:     :|:.:|.|
pombe   909 AINIGYSCNLLDPNMTIF-------RIDANSFGALEEVEAFIRNTLCFNFGYMGTDEEFRFLLKD 966

  Fly   932 ----KQGHALVISGESLEVCL-QYYRPEFLELATASPAVVCCRCSPTQKAQVVALIQKHTGKRTC 991
                ...||:||.|::|...| :.....||.|......|:|||.||:|||.||||::|.....|.
pombe   967 HSPPSPKHAIVIDGDALNFVLSEQVSFLFLMLCKQCKTVLCCRVSPSQKAAVVALVKKSLNVVTL 1031

  Fly   992 AVGDGGNDVSMIQQADAGVGIEGREGRQASLAGDFSIPQFSHIAKLLLIHGRRSYKRSAALSQFV 1056
            |:|||.|||||||:||.||||:|.||:.||::.|::|.|||.:.:|||:|||..|||.:.:..|.
pombe  1032 AIGDGANDVSMIQEADVGVGIKGVEGQAASMSADYAIGQFSFLGRLLLVHGRWDYKRMSQMISFF 1096

  Fly  1057 IHRGLIITTLQAVFSAVFYLSSVALY---QGFLMVGYSTLYTMFPV-FSLVLDQDITSETAVTYP 1117
            .::.:|.|.:  :|...||......|   ..::|: ::.|:|..|| .:...|||:.:..::..|
pombe  1097 FYKNVIWTFI--LFWYQFYNEFDGNYIFDYTYVML-FNLLFTSLPVIIAGCFDQDVDASVSMKNP 1158

  Fly  1118 ELYKDLSKGRSLSYKTFFIWVLISIYQGGVIMYGALILFVDEFIHIVA---------------IS 1167
            .||:....|...:.|.|:.::|..||| .::.:| :.|||.:|...|:               ||
pombe  1159 SLYQRGILGLEWNGKRFWSYMLDGIYQ-SLVCFG-VALFVFKFGDFVSWTGRNIECIEDIGLFIS 1221

  Fly  1168 FSALIMTELIMVALTVRTWHRLMVLAELFSLALYLISLAVLHEYFDWEFIW-----SYDF----- 1222
            ...:.:..:.::....|        ..|.||..::.|:.|   ::.|.||:     ||.|
pombe  1222 SPTIFVINIFILMNQER--------LNLISLITWMFSIGV---FWIWTFIYSEVGPSYAFHKSAS 1275

  Fly  1223 -------LWKVSLITLVSC-LPLYIIKFLRKKCSP 1249
                   .|.|:::|:..| ||.:....|:|...|
pombe  1276 RTCQTFGFWCVTVLTIALCLLPRFSYICLQKLFYP 1310

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31729	NP_609634.1	PhoLip_ATPase_N	227..279	CDD:292826	20/53 (38%)
		ATPase-Plipid	228..1252	CDD:273734	350/1270 (28%)
		E1-E2_ATPase	323..525	CDD:278548	67/293 (23%)
		Cation_ATPase	<704..783	CDD:289987	28/78 (36%)
		HAD_like	<975..1019	CDD:304363	28/43 (65%)
		PhoLip_ATPase_C	1021..1249	CDD:292829	68/264 (26%)
SPAC4F10.16c	NP_594759.1	ATPase-Plipid	128..1318	CDD:273734	350/1270 (28%)
		PhoLip_ATPase_N	<128..174	CDD:292826	19/45 (42%)
		Cation_ATPase	702..800	CDD:289987	38/137 (28%)
		R3H	854..913	CDD:294210	32/58 (55%)
		HAD_like	<1013..1050	CDD:304363	22/36 (61%)
		PhoLip_ATPase_C	1061..1310	CDD:292829	68/264 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910