DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG31729 and SPAC6C3.06c

DIOPT Version :9

Sequence 1:	NP_609634.1	Gene:	CG31729 / 34736	FlyBaseID:	FBgn0051729	Length:	1256	Species:	Drosophila melanogaster
Sequence 2:	NP_593720.1	Gene:	SPAC6C3.06c / 2542915	PomBaseID:	SPAC6C3.06c	Length:	1033	Species:	Schizosaccharomyces pombe

Alignment Length:	1044	Identity:	465/1044 - (44%)
Similarity:	665/1044 - (63%)	Gaps:	94/1044 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly   216 RTVNLGRVNTEKFPPNEIRNQKYNFITFLPLVLFEQFRFFLNLYFLLMALSQFIPDIRIGYPYTY 280
            |.:.:|:...: :..|.:.|.||:..||||..|:||||:|.|:||||::|||.||.::|||..||
pombe    78 RVIQVGQPEPQ-YGNNAVTNTKYDLFTFLPKCLYEQFRYFYNMYFLLVSLSQLIPPLKIGYLSTY 141

  Fly   281 WGPLGFVLMVTICREAVDDLRRHQRDHEVNSQKYKRLSSTNISGYEMVPSSKLKVGDVIIVEKNE 345
            ..||.|||::|:.:||||||:|.:||...|::.|    :.|.|   ...:..::.|||:.:.|::
pombe   142 IAPLIFVLLITLTKEAVDDLKRRRRDSYANNEIY----TVNDS---PCAAQNIQAGDVVYIAKDQ 199

  Fly   346 RVPADLILLRTSDRSGSVFVRTDQLDGETDWKPRLAVPYTQKLSRDSELHSIDASFYVEKPQNDI 410
            |:|||:|||.|: .....|:||||||||||||.|:..         |..|: :...:.:.|...:
pombe   200 RIPADMILLETT-VGNEAFIRTDQLDGETDWKLRIPC---------SNQHT-EGIVHADAPIKSV 253

  Fly   411 HSFIATFCMADGSEDTGLSVENTLWANTVVAAGTATGIVIYTGCETRSVMNNSQPRSKVGLLDME 475
            |.|..||.:  .::...:||::|||||||:|:....|:|:|||.:||..||:|:.::|||||:.|
pombe   254 HHFYGTFTL--NNQKRPISVDHTLWANTVLASDGVYGVVVYTGKDTRQSMNSSKAKTKVGLLEKE 316

  Fly   476 INGLTKVLFCAVLGLSLVMMMLKGFGGPWYRYMFRFVLLFSYIIPISLRVNLDMGKAFYSWQMQN 540
            ||..:|:|...||.||:.:....|....||..:||:::|||.||||:||||||:.|..:|...::
pombe   317 INFYSKILCTFVLVLSIGLTFSHGIKTDWYISVFRYLILFSSIIPINLRVNLDLAKIVHSKNTES 381

  Fly   541 DSNIQGTVVRSTTIPEELGRISYVLTDKTGTLTQNEMVFKKIHLGIVSHDADTFHHIGQMIQKLS 605
            |.|:.|.||||:.||||||||.|||||||||||||||..||:|:|.:...|::...:...||..|
pombe   382 DPNLPGVVVRSSNIPEELGRIEYVLTDKTGTLTQNEMEMKKLHVGTMGFSAESMDVVQACIQNYS 446

  Fly   606 GNI-LQQQQGSLSSSSSGGDSTKPMMFGNRMRRPEGWREWEAVRALALCHNVTPVSDDEDNRSVS 669
            ..| |.:...:|..:                          .|.||:||||||| |...|
pombe   447 TPIPLSEDSKTLVRN--------------------------LVLALSLCHNVTP-SKGHD----- 479

  Fly   670 TASTVTGGNNSPTKSVINIEAPGSTDTEHQYQAASPDEIALVKWTEQVGLTLIARDLNTMTLQVK 734
                          .|::            ||||||||:|:||||..:||.|..|..:.:||
pombe   480 --------------GVVS------------YQAASPDEVAIVKWTSTLGLVLTNRTRDAITL--- 515

  Fly   735 TPSEDNDILLHYQILQLFPFTSESKRMGIIVRESKTGQITFYLKGADVVMSSIVQYNDWLSEESG 799
                :|::   |:||.:|||.||:||||||| :|...:|||||||||.:|.:.|:.:.||.||.|
pombe   516 ----NNNV---YKILNIFPFKSETKRMGIIV-QSPDEKITFYLKGADSIMQNFVKPSFWLEEECG 572

  Fly   800 NMAREGLRTLVVAKKVLTEEQYSDFETRYNAARLSITD-RVAKV-AAVTESLERELELLCLTGVE 862
            |:|||||||||||||.|:.|:||.|...::.|.||.:: |..|: ..|:..||.:::||.|||||
pombe   573 NLAREGLRTLVVAKKDLSAEEYSAFSLAHSDASLSFSNSRDKKMEEIVSRYLENDMDLLGLTGVE 637

  Fly   863 DRLQENVRPTLELLRNAGVRVWMLTGDKLETACCIAKSSQLIGRNQGLHVLRSVKTRTDAHQELN 927
            |:||::|:.|||||||||:.||||||||:|||.|||.||:|:.|.|.:|.:..:.:|.:||..|.
pombe   638 DKLQKDVKITLELLRNAGIHVWMLTGDKVETARCIAISSRLVSRGQYIHTINQLSSREEAHNHLL 702

  Fly   928 SFRRKQGHALVISGESLEVCLQYYRPEFLELATASPAVVCCRCSPTQKAQVVALIQKHTGKRTCA 992
            :.|.|....|:|.|||:|.|:.|.:.||:::.:...:||.|||:|||||.:..|||:......|.
pombe   703 TLRNKPDSCLIIDGESMEFCIGYLQNEFIDIVSDLSSVVICRCTPTQKANMTRLIQEKKQASVCC 767

  Fly   993 VGDGGNDVSMIQQADAGVGIEGREGRQASLAGDFSIPQFSHIAKLLLIHGRRSYKRSAALSQFVI 1057
            :|||||||.|||.|:.|:||.|:||:|||||.|:|:.:|||:::|||.|||.|||:::.|:.|||
pombe   768 IGDGGNDVGMIQVANVGIGIVGKEGQQASLAADYSVKEFSHVSRLLLWHGRISYKQTSKLAMFVI 832

  Fly  1058 HRGLIITTLQAVFSAVFYLSSVALYQGFLMVGYSTLYTMFPVFSLVLDQDITSETAVTYPELYKD 1122
            ||||:|:..|.|:|.:.....:||:||.|:|||||:|||.||||:|.|:|::.:....:|||||:
pombe   833 HRGLLISVCQVVYSVISAFEPIALFQGLLLVGYSTMYTMLPVFSIVYDRDVSEKLVFLFPELYKE 897

  Fly  1123 LSKGRSLSYKTFFIWVLISIYQGGVI-MYGALILFVDEFIHIVAISFSALIMTELIMVALTVRTW 1186
            :.:.:..|||.|...||||:|||.:| ::...::..:|...::|:.||.||..|||||||.:.||
pombe   898 MREQKCFSYKNFISCVLISVYQGLIIQLFTFYLIGFEEEGKMLAVCFSCLIFNELIMVALQINTW 962

  Fly  1187 HRLMVLAELFSLALYLISLAVLHEYFDWEFIWSYDFLWKVSLITLVSCLPLYIIKFLRKKCSPPS 1251
            .:.:|::||.:|.:|::|:..|..||:.:|:....|.|..:||..:|.||::..|.|::|..|.|
pombe   963 EQTIVMSELLTLMMYILSVPFLTNYFELKFLLGLKFYWVSALILFISLLPVWCGKALKRKLKPSS 1027

  Fly  1252 YLKL 1255
            |.||
pombe  1028 YAKL 1031

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31729	NP_609634.1	PhoLip_ATPase_N	227..279	CDD:292826	27/51 (53%)
		ATPase-Plipid	228..1252	CDD:273734	459/1027 (45%)
		E1-E2_ATPase	323..525	CDD:278548	81/201 (40%)
		Cation_ATPase	<704..783	CDD:289987	41/78 (53%)
		HAD_like	<975..1019	CDD:304363	23/43 (53%)
		PhoLip_ATPase_C	1021..1249	CDD:292829	101/228 (44%)
SPAC6C3.06c	NP_593720.1	PhoLip_ATPase_N	79..133	CDD:292826	25/54 (46%)
		ATPase-Plipid	89..1033	CDD:273734	463/1032 (45%)
		E1-E2_ATPase	145..361	CDD:278548	94/235 (40%)
		Cation_ATPase	468..557	CDD:289987	55/131 (42%)
		COG4087	<755..814	CDD:226572	32/58 (55%)
		PhoLip_ATPase_C	796..1026	CDD:292829	101/229 (44%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	242	1.000	Domainoid score	I447
eggNOG	1	0.900	-	-		E1_KOG0210
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H21915
Inparanoid	1	1.050	835	1.000	Inparanoid score	I57
OMA	1	1.010	-	-		QHG53737
OrthoFinder	1	1.000	-	-		FOG0002153
OrthoInspector	1	1.000	-	-		oto101445
orthoMCL	1	0.900	-	-		OOG6_101160
Panther	1	1.100	-	-	LDO	PTHR24092
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5489
SonicParanoid	1	1.000	-	-		X1437
TreeFam	1	0.960	-	-
	14	13.860