Protein Alignment CG31729 and Atp8b4

DIOPT Version :10

• Sequence 1: NP_609634.1
• Gene: CG31729 / 34736
• FlyBaseID: FBgn0051729
• Length: 1256
• Species: Drosophila melanogaster
• Sequence 2: NP_001074413.2
• Gene: Atp8b4 / 241633
• MGIID: 1859664
• Length: 1194
• Species: Mus musculus
• Alignment Length: 1147
• Identity: 355/1147 - (30%)
• Similarity: 548/1147 - (47%)
• Gaps: 198/1147 - (17%)

  Fly   226 EKF--PPNEIRNQKYNFITFLPLVLFEQFRFFLNLYFLLMALSQFIPDIRIGYPYTYWGPLGFVL 288
            |||  ..|.|...|||.:||||:.||||.:...|.|||.:.:.|.||:|.....:|...||..|:
Mouse    25 EKFQYADNRIHTSKYNVLTFLPINLFEQLQRVANAYFLFLLILQLIPEISSLTWFTTIVPLVLVI 89

  Fly   289 MVTICREAVDDLRRHQRDHEVNSQKYKRLSSTNISGYEMVPSSKLKVGDVIIVEKNERVPADLIL 353
            .:|..::|.||..||:.|::||:::.|.|.::.:...:.:   .:||||:|.:|.|:.|.|||:|
Mouse    90 SMTAVKDATDDYFRHKSDNQVNNRQSKVLINSKLQNEKWM---NVKVGDIIKLENNQFVAADLLL 151

  Fly   354 LRTSDRSGSVFVRTDQLDGETDWKPRLAVPYTQKLSRD-SELHSIDASFYVEKPQNDIHSFIATF 417
            |.:|:..|..:|.|.:|||||:.|.|.|:|.|.:|..| |.|...|.....|.|.|.:..|....
Mouse   152 LSSSEPHGLCYVETAELDGETNLKVRQALPVTSELGADISSLAEFDGIVRCEAPNNKLDRFSGVL 216

  Fly   418 CMADGSED--------TGLSVENTLWANTVVAAGTATGIVIYTGCETRSVMNNSQPRSKVGLLDM 474
            ...|....        .|..:.||.|         ..|:|::.|.:|:.:.|:.:.:.|...:|.
Mouse   217 SWKDSKHALSNQKIILRGCVLRNTSW---------CFGMVLFAGPDTKLMQNSGKTKFKRTSIDR 272

  Fly   475 EINGLTKVLF----CAVLGLSLVMMMLKGFGG------PWYR-----YMFR-FVLLFSYII---- 519
            .:|.|...:|    |..:.|::...:|:...|      |::|     ::|. |:..:||:|
Mouse   273 LMNTLVLWIFGFLVCLGIILAVGSSILESEVGDQFRTPPFWREGEKSFLFSGFLTFWSYVIILNT 337

  Fly   520 --PISLRVNLD---MGKAFY-SW--QMQNDSNIQGTVVRSTTIPEELGRISYVLTDKTGTLTQNE 576
              ||||.|:::   :|.::: :|  :|...|.......|:||:.||||:|.|:.:|||||||||.
Mouse   338 LVPISLYVSVEVIRLGHSYFINWDRKMYYASKAMPAEARTTTLNEELGQIEYIFSDKTGTLTQNI 402

  Fly   577 MVFKK------IHLGIVSHDADTFHHIGQMIQKLSGNILQQQQGSLSSSSSGGDST-----KPMM 630
            |.|||      ::.|.|..|.         |||  ..|.::::.:..||.|..:.|     :.:|
Mouse   403 MTFKKCSINGRVYAGEVLDDP---------IQK--KEITKEKEATDFSSKSKSEKTLHFFDQSLM 456

  Fly   631 FGNRMRRPEGWREWEAVRALALCHNVTPVSDDEDNRSVSTASTVTGGNNSPTKSVINIEAPGSTD 695
            ....:..|   :..|.:|.|||||                  ||....||..:.|
Mouse   457 ESIELGDP---KVHEFLRLLALCH------------------TVMSEENSAGQLV---------- 490

  Fly   696 TEHQYQAASPDEIALVKWTEQVGLTLIARDLNTMTL-QVKTPSEDNDILLHYQILQLFPFTSESK 759
                ||..||||.|||......|....:|...|:|: ::.||       :.||:|....|.:..|
Mouse   491 ----YQVQSPDEGALVTAARNFGFIFKSRTPETITIEELGTP-------VTYQLLAFLDFNNIRK 544

  Fly   760 RMGIIVRESKTGQITFYLKGADVV-----------MSSIVQYNDWLSEESGNMAREGLRTLVVAK 813
            ||.:|||..: |:|..|.||||.:           :.|:.  :|.|||.:|    ||||||.:|.
Mouse   545 RMSVIVRNPE-GRIKLYSKGADTILFEKLHPSNEDLQSLT--SDHLSEFAG----EGLRTLAIAY 602

  Fly   814 KVLTEEQYSDFETRYNAARLSITDRVAKVAAVTESLERELELLCLTGVEDRLQENVRPTLELLRN 878
            :.|.::.:..::.....|..:..:|..:::.:.|.:||:|.||..|.|||:|||.|..|:..|..
Mouse   603 RELDDKYFKMWQKMLEDANSATLERDERISGLYEEIERDLMLLGATAVEDKLQEGVIETITSLSL 667

  Fly   879 AGVRVWMLTGDKLETACCIAKSSQLIGRNQGLHVLRSVKTRTDAHQELNSFRR---------KQG 934
            |.:::|:|||||.|||..|..:..::........:.:..|..:..:||...:.         ..|
Mouse   668 ANIKIWILTGDKQETAINIGYACNVLTDAMDALFVITGNTAGEVREELRKAKENLLGQSTSFSNG 732

  Fly   935 H-----------------------ALVISGESLEVCLQY-YRPEFLELATASPAVVCCRCSPTQK 975
            |                       ||||:|.||...|:. ...:.||||.....|||||.:|.||
Mouse   733 HAVYDNKQRLGLDAGAGEAVTGEYALVINGHSLAHALESDVENDLLELACVCKTVVCCRVTPLQK 797

  Fly   976 AQVVALIQKHTGKRTCAVGDGGNDVSMIQQADAGVGIEGREGRQASLAGDFSIPQFSHIAKLLLI 1040
            ||||.|::||....|.|:|||.||||||:.|..|:||.|:||.||.||.|:::.||.::.:|||:
Mouse   798 AQVVELVKKHRNAVTLAIGDGANDVSMIKSAHIGIGISGQEGLQAVLASDYALAQFRYLQRLLLV 862

  Fly  1041 HGRRSYKRSAALSQFVIHRGLIITTLQAVFSAVFYLSSVALYQGFLMVGYSTLYTMFPVFSL-VL 1104
            |||.||.|......:..::....|.:...|:.....|:..:|..:.:..::.:||..||.:: :.
Mouse   863 HGRWSYYRMCKFLCYFFYKNFAFTLVHFWFAFFCGFSAQTVYDQWFITLFNIVYTSLPVLAMGMF 927

  Fly  1105 DQDITSETAVTYPELYKDLSKGRSLSYKTFFIWVLISIYQG---GVIMYGALI-LFVDEFIHIVA 1165
            ||||..:.::.||:||:........:.:.|||.|...||..   ..|.|||.. :..::..||..
Mouse   928 DQDINEQNSMDYPQLYEPGQLNLLFNKRRFFICVAHGIYTSLALFFIPYGAFYNVAAEDGQHIAD 992

  Fly  1166 I-SFSALIMTELIMV-----ALTVRTWHRLMVLAELF---SLALYLISLAVLHE-----YFDWEF 1216
            : ||:..:.|.|::|     ||....|   .|:..:|   |:|.|...|..:|.     .|...|
Mouse   993 LQSFAVTVATSLVIVVSIQIALDTSYW---TVVNHVFIWGSVATYFSILLAMHSDGVFGIFPRHF 1054

  Fly  1217 IW--------SYDFLWKVSLITLV-SCLPLYIIKFLRKKCSP 1249
            .:        |..|:|.|.|:|.| |.:|:.:::||:....|
Mouse  1055 PFVGNARHSLSQKFVWLVVLLTAVTSVMPVVVVRFLKMYLYP 1096

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG31729	NP_609634.1	P-type_ATPase_APLT_Neo1-like	230..1177	CDD:319841	326/1045 (31%)
		Cation_ATPase	<704..781	CDD:463817	28/77 (36%)
Atp8b4	NP_001074413.2	P-type_ATPase_APLT_Dnf-like	31..975	CDD:319770	317/1015 (31%)