Protein Alignment CG31729 and ATP11B

DIOPT Version :10

• Sequence 1: NP_609634.1
• Gene: CG31729 / 34736
• FlyBaseID: FBgn0051729
• Length: 1256
• Species: Drosophila melanogaster
• Sequence 2: NP_055431.1
• Gene: ATP11B / 23200
• HGNCID: 13553
• Length: 1177
• Species: Homo sapiens
• Alignment Length: 1152
• Identity: 346/1152 - (30%)
• Similarity: 558/1152 - (48%)
• Gaps: 177/1152 - (15%)

  Fly   204 WRKWFR-------PRELRARTVNL-------GRVNTEKFPPNEIRNQKYNFITFLPLVLFEQFRF 254
            || |.|       |.:...||:.:       |....:||..|.|.:.||....|:|..||||||.
Human     2 WR-WIRQQLGFDPPHQSDTRTIYVANRFPQNGLYTPQKFIDNRIISSKYTVWNFVPKNLFEQFRR 65

  Fly   255 FLNLYFLLMALSQFIPDIRIGYPYTYWGPLGFVLMVTICREAVDDLRRHQRDHEVNSQKYKRLSS 319
            ..|.|||::.|.|.:.|.... |.|...||.||:.||..::..:|..||..|:|||......:.|
Human    66 VANFYFLIIFLVQLMIDTPTS-PVTSGLPLFFVITVTAIKQGYEDWLRHNSDNEVNGAPVYVVRS 129

  Fly   320 TNISGYEMVPSSKLKVGDVIIVEKNERVPADLILLRTSDRSGSVFVRTDQLDGETDWKPRLAVPY 384
               .|.....|..::|||::.:.|:|..||||:||.:....||..|.|..|||||:.|..:|||.
Human   130 ---GGLVKTRSKNIRVGDIVRIAKDEIFPADLVLLSSDRLDGSCHVTTASLDGETNLKTHVAVPE 191

  Fly   385 TQKLSRDSELHSIDASFYVEKPQNDIHSFIATFCMADGSEDTGLSVENTLWANTVVAAGTAT--- 446
            |..|...:.|.::.|....::|:.|::.|:....:....|:    :...|...:::..|...
Human   192 TALLQTVANLDTLVAVIECQQPEADLYRFMGRMIITQQMEE----IVRPLGPESLLLRGARLKNT 252

  Fly   447 ----GIVIYTGCETRSVMNNSQPRSKVGLLDMEINGLTKVLFCAVLGLSLVMMMLK-------GF 500
                |:.:|||.||:..:|......|...::..:|....:....::..:::..:||       .:
Human   253 KEIFGVAVYTGMETKMALNYKSKSQKRSAVEKSMNTFLIIYLVILISEAVISTILKYTWQAEEKW 317

  Fly   501 GGPWY--------------RYM---FRFVLLFSYIIPISLRVNLDM----GKAFYSWQMQ--NDS 542
            ..|||              |::   ..|::|:::||||||.|.::|    |..|..|.:.  ::.
Human   318 DEPWYNQKTEHQRNSSKILRFISDFLAFLVLYNFIIPISLYVTVEMQKFLGSFFIGWDLDLYHEE 382

  Fly   543 NIQGTVVRSTTIPEELGRISYVLTDKTGTLTQNEMVFKKIHLGIVSHDADTFHHIGQMIQKLSGN 607
            :.|...|.::.:.||||::.||.||||||||:|||.|::..:.            |...|:::|.
Human   383 SDQKAQVNTSDLNEELGQVEYVFTDKTGTLTENEMQFRECSIN------------GMKYQEINGR 435

  Fly   608 ILQQ------QQGSLS--SSSSGGDSTKPMMFGNRMR-RPEGWREWEAV-------RALALCHNV 656
            ::.:      .:|:||  ||.|..::...:...:..| .||  .|.|.:       :|::|||.|
Human   436 LVPEGPTPDSSEGNLSYLSSLSHLNNLSHLTTSSSFRTSPE--NETELIKEHDLFFKAVSLCHTV 498

  Fly   657 TPVSDDEDNRSVSTASTVTGGNNSPTKSVINIEAPGSTDTEHQYQAASPDEIALVKWTEQVGLTL 721
                      .:|...|...| :.|.:|.:   ||    ::.:|.|:||||.|||:...::|:..
Human   499 ----------QISNVQTDCTG-DGPWQSNL---AP----SQLEYYASSPDEKALVEAAARIGIVF 545

  Fly   722 IARDLNTMTLQVKTPSEDNDILLHYQILQLFPFTSESKRMGIIVRESKTGQITFYLKGADVVMSS 786
            |.....||  :|||..:    |..|::|.:..|.|:.:||.:|| ::.:|:...:.|||:   ||
Human   546 IGNSEETM--EVKTLGK----LERYKLLHILEFDSDRRRMSVIV-QAPSGEKLLFAKGAE---SS 600

  Fly   787 IVQ------------YNDWLSEESGNMAREGLRTLVVAKKVLTEEQYSDFETRYNAARLSITDRV 839
            |:.            :.|       ..|.:|||||.:|.:..|.::|.:.:.|...||.::..|.
Human   601 ILPKCIGGEIEKTRIHVD-------EFALKGLRTLCIAYRKFTSKEYEEIDKRIFEARTALQQRE 658

  Fly   840 AKVAAVTESLERELELLCLTGVEDRLQENVRPTLELLRNAGVRVWMLTGDKLETACCIAKSSQLI 904
            .|:|||.:.:|::|.||..|.||||||:.||.|:|.||.||::||:|||||.|||..::.|....
Human   659 EKLAAVFQFIEKDLILLGATAVEDRLQDKVRETIEALRMAGIKVWVLTGDKHETAVSVSLSCGHF 723

  Fly   905 GRNQGLHVLRSVKTRTDAHQELNSFRRK------QGHALVISGESLEVCLQYYRPEFLELATASP 963
            .|...:..|.:.|:.::..::|....|:      ..|.||:.|.||.:.|:.:...|:|:.....
Human   724 HRTMNILELINQKSDSECAEQLRQLARRITEDHVIQHGLVVDGTSLSLALREHEKLFMEVCRNCS 788

  Fly   964 AVVCCRCSPTQKAQVVALIQKHTGKR-TCAVGDGGNDVSMIQQADAGVGIEGREGRQASLAGDFS 1027
            ||:|||.:|.|||:|:.||:....|. |.|||||.|||||||:|..|:||.|:|||||:...|::
Human   789 AVLCCRMAPLQKAKVIRLIKISPEKPITLAVGDGANDVSMIQEAHVGIGIMGKEGRQAARNSDYA 853

  Fly  1028 IPQFSHIAKLLLIHGRRSYKRSAALSQFVIHRGLIITTLQAVFSAVFYLSSVALYQGFLMVGYST 1092
            |.:|..::|||.:||...|.|.|.|.|:..::.:...|.|.::......|...||....:..|:.
Human   854 IARFKFLSKLLFVHGHFYYIRIATLVQYFFYKNVCFITPQFLYQFYCLFSQQTLYDSVYLTLYNI 918

  Fly  1093 LYTMFP--VFSLVLDQDITSETAVTYPELYKDLSKGRSLSYKTFFIWVLISIYQGGVIMYGALIL 1155
            .:|..|  ::|| |:|.:........|.||:|:||.|.||.|||..|.::......:..:|:.:|
Human   919 CFTSLPILIYSL-LEQHVDPHVLQNKPTLYRDISKNRLLSIKTFLYWTILGFSHAFIFFFGSYLL 982

  Fly  1156 FVDE--------------FIHIVAISFSALIMTELIMVALTVRTWHRLMVLAELFSLALYLISLA 1206
            ...:              |..:|   |:.:::|..:.:||....|..:..|....|:..|.: .:
Human   983 IGKDTSLLGNGQMFGNWTFGTLV---FTVMVITVTVKMALETHFWTWINHLVTWGSIIFYFV-FS 1043

  Fly  1207 VLHEYFDWEFIWSYDF------------LWKVSLITLVSCLPLYIIK 1241
            :.:....|.|:.|.:.            .|...::.:|:||.|.|||
Human  1044 LFYGGILWPFLGSQNMYFVFIQLLSSGSAWFAIILMVVTCLFLDIIK 1090

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG31729	NP_609634.1	P-type_ATPase_APLT_Neo1-like	230..1177	CDD:319841	319/1034 (31%)
		Cation_ATPase	<704..781	CDD:463817	26/76 (34%)
ATP11B	NP_055431.1	P-type_ATPase_APLT_Dnf-like	41..979	CDD:319770	313/995 (31%)