DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG31729 and ATP11B

DIOPT Version :9

Sequence 1:	NP_609634.1	Gene:	CG31729 / 34736	FlyBaseID:	FBgn0051729	Length:	1256	Species:	Drosophila melanogaster
Sequence 2:	NP_055431.1	Gene:	ATP11B / 23200	HGNCID:	13553	Length:	1177	Species:	Homo sapiens

Alignment Length:	1151	Identity:	347/1151 - (30%)
Similarity:	558/1151 - (48%)	Gaps:	175/1151 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   204 WRKWFR-------PRELRARTVNL-------GRVNTEKFPPNEIRNQKYNFITFLPLVLFEQFRF 254
            || |.|       |.:...||:.:       |....:||..|.|.:.||....|:|..||||||.
Human     2 WR-WIRQQLGFDPPHQSDTRTIYVANRFPQNGLYTPQKFIDNRIISSKYTVWNFVPKNLFEQFRR 65

  Fly   255 FLNLYFLLMALSQFIPDIRIGYPYTYWGPLGFVLMVTICREAVDDLRRHQRDHEVNSQKYKRLSS 319
            ..|.|||::.|.|.:.|.... |.|...||.||:.||..::..:|..||..|:|||......:.|
Human    66 VANFYFLIIFLVQLMIDTPTS-PVTSGLPLFFVITVTAIKQGYEDWLRHNSDNEVNGAPVYVVRS 129

  Fly   320 TNISGYEMVPSSKLKVGDVIIVEKNERVPADLILLRTSDRSGSVFVRTDQLDGETDWKPRLAVPY 384
               .|.....|..::|||::.:.|:|..||||:||.:....||..|.|..|||||:.|..:|||.
Human   130 ---GGLVKTRSKNIRVGDIVRIAKDEIFPADLVLLSSDRLDGSCHVTTASLDGETNLKTHVAVPE 191

  Fly   385 TQKLSRDSELHSIDASFYVEKPQNDIHSFIATFCMADGSEDTGLSVENTLWANTVVAAGTAT--- 446
            |..|...:.|.::.|....::|:.|::.|:....:....|:    :...|...:::..|...
Human   192 TALLQTVANLDTLVAVIECQQPEADLYRFMGRMIITQQMEE----IVRPLGPESLLLRGARLKNT 252

  Fly   447 ----GIVIYTGCETRSVMNNSQPRSKVGLLDMEINGLTKVLFCAVLGLSLVMMMLK-------GF 500
                |:.:|||.||:..:|......|...::..:|....:....::..:::..:||       .:
Human   253 KEIFGVAVYTGMETKMALNYKSKSQKRSAVEKSMNTFLIIYLVILISEAVISTILKYTWQAEEKW 317

  Fly   501 GGPWY--------------RYM---FRFVLLFSYIIPISLRVNLDM----GKAFYSWQMQ--NDS 542
            ..|||              |::   ..|::|:::||||||.|.::|    |..|..|.:.  ::.
Human   318 DEPWYNQKTEHQRNSSKILRFISDFLAFLVLYNFIIPISLYVTVEMQKFLGSFFIGWDLDLYHEE 382

  Fly   543 NIQGTVVRSTTIPEELGRISYVLTDKTGTLTQNEMVFKKIHLGIVSHDADTFHHIGQMIQKLSGN 607
            :.|...|.::.:.||||::.||.||||||||:|||.|::..:.            |...|:::|.
Human   383 SDQKAQVNTSDLNEELGQVEYVFTDKTGTLTENEMQFRECSIN------------GMKYQEINGR 435

  Fly   608 ILQQ------QQGSLS--SSSSGGDSTKPMMFGNRMR-RPEGWREWEAV-------RALALCHNV 656
            ::.:      .:|:||  ||.|..::...:...:..| .||  .|.|.:       :|::|||.|
Human   436 LVPEGPTPDSSEGNLSYLSSLSHLNNLSHLTTSSSFRTSPE--NETELIKEHDLFFKAVSLCHTV 498

  Fly   657 TPVSDDEDNRSVSTASTVTGGNNSPTKSVINIEAPGSTDTEHQYQAASPDEIALVKWTEQVGLTL 721
                      .:|...|...| :.|.:|.:   ||    ::.:|.|:||||.|||:...::|:..
Human   499 ----------QISNVQTDCTG-DGPWQSNL---AP----SQLEYYASSPDEKALVEAAARIGIVF 545

  Fly   722 IARDLNTMTLQVKTPSEDNDILLHYQILQLFPFTSESKRMGIIVRESKTGQITFYLKGADVVMSS 786
            |.....||  :|||..:    |..|::|.:..|.|:.:||.:|| ::.:|:...:.|||:   ||
Human   546 IGNSEETM--EVKTLGK----LERYKLLHILEFDSDRRRMSVIV-QAPSGEKLLFAKGAE---SS 600

  Fly   787 IVQYNDWLSEESG-----------NMAREGLRTLVVAKKVLTEEQYSDFETRYNAARLSITDRVA 840
            |      |.:..|           ..|.:|||||.:|.:..|.::|.:.:.|...||.::..|..
Human   601 I------LPKCIGGEIEKTRIHVDEFALKGLRTLCIAYRKFTSKEYEEIDKRIFEARTALQQREE 659

  Fly   841 KVAAVTESLERELELLCLTGVEDRLQENVRPTLELLRNAGVRVWMLTGDKLETACCIAKSSQLIG 905
            |:|||.:.:|::|.||..|.||||||:.||.|:|.||.||::||:|||||.|||..::.|.....
Human   660 KLAAVFQFIEKDLILLGATAVEDRLQDKVRETIEALRMAGIKVWVLTGDKHETAVSVSLSCGHFH 724

  Fly   906 RNQGLHVLRSVKTRTDAHQELNSFRRK------QGHALVISGESLEVCLQYYRPEFLELATASPA 964
            |...:..|.:.|:.::..::|....|:      ..|.||:.|.||.:.|:.:...|:|:.....|
Human   725 RTMNILELINQKSDSECAEQLRQLARRITEDHVIQHGLVVDGTSLSLALREHEKLFMEVCRNCSA 789

  Fly   965 VVCCRCSPTQKAQVVALIQKHTGKR-TCAVGDGGNDVSMIQQADAGVGIEGREGRQASLAGDFSI 1028
            |:|||.:|.|||:|:.||:....|. |.|||||.|||||||:|..|:||.|:|||||:...|::|
Human   790 VLCCRMAPLQKAKVIRLIKISPEKPITLAVGDGANDVSMIQEAHVGIGIMGKEGRQAARNSDYAI 854

  Fly  1029 PQFSHIAKLLLIHGRRSYKRSAALSQFVIHRGLIITTLQAVFSAVFYLSSVALYQGFLMVGYSTL 1093
            .:|..::|||.:||...|.|.|.|.|:..::.:...|.|.::......|...||....:..|:..
Human   855 ARFKFLSKLLFVHGHFYYIRIATLVQYFFYKNVCFITPQFLYQFYCLFSQQTLYDSVYLTLYNIC 919

  Fly  1094 YTMFP--VFSLVLDQDITSETAVTYPELYKDLSKGRSLSYKTFFIWVLISIYQGGVIMYGALILF 1156
            :|..|  ::|| |:|.:........|.||:|:||.|.||.|||..|.::......:..:|:.:|.
Human   920 FTSLPILIYSL-LEQHVDPHVLQNKPTLYRDISKNRLLSIKTFLYWTILGFSHAFIFFFGSYLLI 983

  Fly  1157 VDE--------------FIHIVAISFSALIMTELIMVALTVRTWHRLMVLAELFSLALYLISLAV 1207
            ..:              |..:|   |:.:::|..:.:||....|..:..|....|:..|.: .::
Human   984 GKDTSLLGNGQMFGNWTFGTLV---FTVMVITVTVKMALETHFWTWINHLVTWGSIIFYFV-FSL 1044

  Fly  1208 LHEYFDWEFIWSYDF------------LWKVSLITLVSCLPLYIIK 1241
            .:....|.|:.|.:.            .|...::.:|:||.|.|||
Human  1045 FYGGILWPFLGSQNMYFVFIQLLSSGSAWFAIILMVVTCLFLDIIK 1090

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31729	NP_609634.1	PhoLip_ATPase_N	227..279	CDD:292826	22/51 (43%)
		ATPase-Plipid	228..1252	CDD:273734	338/1113 (30%)
		E1-E2_ATPase	323..525	CDD:278548	59/232 (25%)
		Cation_ATPase	<704..783	CDD:289987	27/78 (35%)
		HAD_like	<975..1019	CDD:304363	26/44 (59%)
		PhoLip_ATPase_C	1021..1249	CDD:292829	61/249 (24%)
ATP11B	NP_055431.1	PhoLip_ATPase_N	35..89	CDD:292826	22/54 (41%)
		ATPase-Plipid	39..1106	CDD:273734	338/1113 (30%)
		E1-E2_ATPase	96..>180	CDD:278548	31/86 (36%)
		Cation_ATPase	494..605	CDD:289987	44/144 (31%)
		HAD_like	629..868	CDD:304363	97/238 (41%)
		PhoLip_ATPase_C	847..1100	CDD:292829	61/249 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165144901
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D587717at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.850