DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG31729 and Atp10d

DIOPT Version :9

Sequence 1:	NP_609634.1	Gene:	CG31729 / 34736	FlyBaseID:	FBgn0051729	Length:	1256	Species:	Drosophila melanogaster
Sequence 2:	NP_700438.3	Gene:	Atp10d / 231287	MGIID:	2450125	Length:	1469	Species:	Mus musculus

Alignment Length:	1363	Identity:	380/1363 - (27%)
Similarity:	586/1363 - (42%)	Gaps:	335/1363 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   182 HNRRKSKSRSIG------NVCKLCLCSCWRKWFRPRELRARTVNLGRVNTEK---------FPPN 231
            |.||.|..|:.|      |...|..|. .:....||......|.:..:...|         :..|
Mouse    64 HWRRLSHGRAQGEDERPYNYASLLACG-GKSSRTPRPAGKHRVVIPHLQCFKDEYERFSGTYVNN 127

  Fly   232 EIRNQKYNFITFLPLVLFEQFRFFLNLYFLLMALSQFIPDIRIGYPYTYWGPLGFVLMVTICREA 296
            .||..||..:.|:|..|||||....|||||.:.:..::|.:..........||..||.:...::.
Mouse   128 RIRTTKYTLLNFVPRNLFEQFHRAANLYFLFLVVLNWVPLVEAFQKEITMLPLVVVLTIIAIKDG 192

  Fly   297 VDDLRRHQRDHEVNS----------QKYKRLSSTNISGYEMVPSSKLKVGDVIIVEKNERVPADL 351
            ::|.|:::.|.::|:          :||......|::           |||.|.:..||.:|||:
Mouse   193 LEDYRKYKIDKQINNLITKVYSRKEKKYIDCCWKNVT-----------VGDFIRLSCNEIIPADM 246

  Fly   352 ILLRTSDRSGSVFVRTDQLDGETDWKPRLAV-PYTQKLSRDSEL--HSIDASFYVEKPQNDIHSF 413
            :||.::|..|...:.|..||||::.|.|..| .||:   :|||:  ....:....|.|.||:..|
Mouse   247 VLLFSTDPDGICHIETSGLDGESNLKQRQVVRGYTE---QDSEVDPEKFSSRIECESPNNDLSRF 308

  Fly   414 IATFCMADGSEDTGLSVENTLWAN-TVVAAGTATGIVIYTGCETRSVMNNSQPRSKVGLLDMEIN 477
             ..|......|..|||.||.|... |:.......|||:|.|.||::::|||.||.|...|:...|
Mouse   309 -RGFLEHANKERVGLSKENLLLRGCTIRNTEAVVGIVVYAGHETKAMLNNSGPRYKRSKLERRAN 372

  Fly   478 GLTKVLFCAVLGLSLVMMMLKG-FG-GPW---YRYMFRF-----------------------VLL 514
              |.||:|.:|   |::|.|.| .| |.|   |..|..|                       ::|
Mouse   373 --TDVLWCVLL---LIVMCLTGALGHGIWLSRYENMLFFNIPEPDGRVISPVLTGFYVFWTMIIL 432

  Fly   515 FSYIIPISLRVNLDMGKA-----------FYSWQMQNDSNIQGTVVRSTTIPEELGRISYVLTDK 568
            ...:|||||.|::::.|.           ||:.:|  ||.||   .|:..|.|:||:|.|:.:||
Mouse   433 LQVLIPISLYVSIEIVKLGQIYFIQSDVDFYNEKM--DSTIQ---CRALNITEDLGQIQYLFSDK 492

  Fly   569 TGTLTQNEMVFKKIHLG------------------IVSHDADTFHHIGQMIQKLS---------- 605
            |||||:|:|||::..:.                  .||.:.:....:|..:..::
Mouse   493 TGTLTENKMVFRRCSVAGFDYCHEENAKRLESYQEAVSEEEECTDTLGGSLSNMARPRAQGCRTV 557

  Fly   606 -----GNILQQQQGSLSSSSSGGDS-----------TKPM------------------------M 630
                 |....|..||.|:..:|..|           :.||                        :
Mouse   558 PSGPLGKPSAQLSGSTSAVGNGEGSGEVPHSRQAAFSSPMETDVVPDTRLLDKFSQLTPQLLTGL 622

  Fly   631 FGNRMRRP-EGWREWEAVRALALCHNVT-------------------PVSDDEDNRSV------- 668
            .|.....| |.....:...|||:|:.|.                   |:...|:.:::
Mouse   623 DGTAQSSPLETLYIMDFFIALAICNTVVVSAPNQPRQKIGLSSLGGMPIKSLEEIKNIFQKLSVR 687

  Fly   669 --STASTVTGGNNS---PTKSVINI--------------------EAPGS------TDTEHQ--- 699
              |:.|..:|.::|   |...|..|                    |.|.:      |:||.|
Mouse   688 RSSSPSLASGKDSSSGTPCAFVSRISFFSRPKLSPPMEDESSQMDEIPQASNSACCTETEAQNRA 752

  Fly   700 ----------------------YQAASPDEIALVKWTEQVGLTLIARDLNTMTLQVKTPSE---D 739
                                  |:|.||||.|||          .|......|||.:||.:   |
Mouse   753 VGLSVSSAEALSGPPPSASNLCYEAESPDEAALV----------YAARAYRCTLQSRTPEQVMVD 807

  Fly   740 NDIL--LHYQILQLFPFTSESKRMGIIVRESKTGQITFYLKGADVVMSSI--VQYNDWLSEESGN 800
            ...|  |.:|:|.:.||.|..|||.::||...:.|:..|.||||.|:..:  |..:|..:.|...
Mouse   808 FAALGSLTFQLLHILPFDSVRKRMSVVVRHPLSKQVVVYTKGADSVIMELLSVAASDGTNPEQQM 872

  Fly   801 MARE------------GLRTLVVAKKVLTEEQYSDFETRYNAARLSITDRVAKVAAVTESLEREL 853
            :.||            |||||.|||||:::.:|:::...:..|..||.:|...:......||.:|
Mouse   873 IIRERTQRHLDEYAKRGLRTLCVAKKVMSDTEYAEWLRNHFLAETSIDNREELLVESAMRLENKL 937

  Fly   854 ELLCLTGVEDRLQENVRPTLELLRNAGVRVWMLTGDKLETACCIAKSSQLIGRNQGLHVLRS--- 915
            .||..||:||||||.|..::|.|..||:::|||||||.|||..||.:.:|:..:..|.:|.:
Mouse   938 TLLGATGIEDRLQEGVPESIEALHQAGIKIWMLTGDKQETAVNIAYACKLLEPDDKLFILNTQSQ 1002

  Fly   916 -------------VKTRTDAHQELNSFRRK---------QGHA-LVISGESLEVCLQ-YYRPEFL 956
                         ::.|.....||.|.|:.         ||.| |||:|::||..|| ..:.:||
Mouse  1003 DACGMLMSAILEELQKRAQVSPELASSRKNFPQPSDAQGQGRAGLVITGKTLEFALQESLQRQFL 1067

  Fly   957 ELATASPAVVCCRCSPTQKAQVVALIQKHTGKRTCAVGDGGNDVSMIQQADAGVGIEGREGRQAS 1021
            ||.....||:|||.:|.||::||.|::.|....|..:|||.|||||||.||.|:|:.|:||.||.
Mouse  1068 ELTAWCQAVICCRATPLQKSEVVKLVRNHHHVLTLPIGDGANDVSMIQVADIGIGVSGQEGMQAV 1132

  Fly  1022 LAGDFSIPQFSHIAKLLLIHGRRSYKRSAALSQFVIHRGLIITTLQAVFSAVFYLSSVALYQGFL 1086
            :|.||:|.||.|::||||:||...|.|.:.:..:..::.:....|...:......|..::...::
Mouse  1133 MASDFAISQFRHLSKLLLVHGHWCYTRLSNMILYFFYKNVAYVNLLFWYQFFCGFSGTSMTDYWV 1197

  Fly  1087 MVGYSTLYTMF-PVFSLVLDQDITSETAVTYPELYKDLSKGRSLSYKTFFIWVLISIYQGGVIMY 1150
            ::.::.|:|.. |:...||::|:::||.:..||||:...:.......||:|.:|.:.||..|..:
Mouse  1198 LIFFNLLFTSVPPIIYGVLEKDVSAETLLQLPELYRSGQRSEEYLPLTFWITLLDAFYQSLVCFF 1262

  Fly  1151 GALILF----VDEFIHIVAISFSALIMTELIMVALTVR----TW-HRLMVLAELFSLALYLISLA 1206
            .....:    :|.|.....::.:||.   :|::.|.:.    || |.|:.:..:.|...:.::..
Mouse  1263 VPYFTYQGSDIDIFTFGNPLNTAALF---IILLHLVIESKSLTWIHMLVTVGSILSYFFFALAFG 1324

  Fly  1207 VL---------------HEYFDWEFIWSYDFLWKVSLITLVSCLPLYIIKFLRKKCSPPSYLK 1254
            .|               ....|..|     :|..| |.|.|:.||.::.:.|:....|...|:
Mouse  1325 ALCVTCNPPSNPYGIMRKHMLDPVF-----YLVCV-LTTFVALLPRFLYRVLQGSVFPSPVLR 1381

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31729	NP_609634.1	PhoLip_ATPase_N	227..279	CDD:292826	19/60 (32%)
		ATPase-Plipid	228..1252	CDD:273734	366/1298 (28%)
		E1-E2_ATPase	323..525	CDD:278548	76/233 (33%)
		Cation_ATPase	<704..783	CDD:289987	32/83 (39%)
		HAD_like	<975..1019	CDD:304363	23/43 (53%)
		PhoLip_ATPase_C	1021..1249	CDD:292829	58/252 (23%)
Atp10d	NP_700438.3	ATPase-Plipid	124..1377	CDD:273734	365/1296 (28%)
		PhoLip_ATPase_N	<124..175	CDD:292826	18/50 (36%)
		E1-E2_ATPase	181..406	CDD:278548	78/244 (32%)
		Cation_ATPase	<779..859	CDD:289987	33/89 (37%)
		HAD_like	<1101..1132	CDD:304363	19/30 (63%)
		PhoLip_ATPase_C	1132..1377	CDD:292829	58/253 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167835005
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53737
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.940