DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG31729 and ATP10B

DIOPT Version :9

Sequence 1:	NP_609634.1	Gene:	CG31729 / 34736	FlyBaseID:	FBgn0051729	Length:	1256	Species:	Drosophila melanogaster
Sequence 2:	NP_001353581.1	Gene:	ATP10B / 23120	HGNCID:	13543	Length:	1461	Species:	Homo sapiens

Alignment Length:	1351	Identity:	368/1351 - (27%)
Similarity:	578/1351 - (42%)	Gaps:	318/1351 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   163 THSTTVIDPENGSSTVFYQHNRRKSKSRSIGNVCKLCLCSCWRKWFRPRELRARTVNLGRVNTEK 227
            :.:|.::.||.|..:......|....:.||.:       ..|.:..|                 :
Human    25 SETTPLLSPEKGRQSYNLTQQRVVFPNNSIFH-------QDWEEVSR-----------------R 65

  Fly   228 FPPNEIRNQKYNFITFLPLVLFEQFRFFLNLYFLLMALSQFIPDIRIGYPYTYWGPLGFVLMVTI 292
            :|.|.....||...||||..|||||..:.|||||.:.:..::|.:.:.:......||..||.|.:
Human    66 YPGNRTCTTKYTLFTFLPRNLFEQFHRWANLYFLFLVILNWMPSMEVFHREITMLPLAIVLFVIM 130

  Fly   293 CREAVDDLRRHQRDHEVNSQK---YKRLSSTNISGYEMVPSSKLKVGDVIIVEKNERVPADLILL 354
            .::.::|.:||:.|..:|...   |:|...|    |.......::|||.|.::.||.||||::||
Human   131 IKDGMEDFKRHRFDKAINCSNIRIYERKEQT----YVQKCWKDVRVGDFIQMKCNEIVPADILLL 191

  Fly   355 RTSDRSGSVFVRTDQLDGETDWKPRLAVP--YTQKLSRDSEL-HSIDASFYVEKPQNDIHSFIAT 416
            .:||.:|...:.|..|||||:.|.|..|.  ..|::..:.|| |:   :...|||.|.::.|...
Human   192 FSSDPNGICHLETASLDGETNLKQRCVVKGFSQQEVQFEPELFHN---TIVCEKPNNHLNKFKGY 253

  Fly   417 FCMADGSEDTGLSVENTLWAN-TVVAAGTATGIVIYTGCETRSVMNNSQPRSKVGLLDMEINGLT 480
            ....|.:. ||...|:.|... |:.....|.|||||.|.||::::|||.||.|...::..:|  .
Human   254 MEHPDQTR-TGFGCESLLLRGCTIRNTEMAVGIVIYAGHETKAMLNNSGPRYKRSKIERRMN--I 315

  Fly   481 KVLFCAVLGLSLVMMMLKGFG----------------------------GPWYRYMFRFVLLFSY 517
            .:.||  :|:.::|.::...|                            |.:|.:: ..::|...
Human   316 DIFFC--IGILILMCLIGAVGHSIWNGTFEEHPPFDVPDANGSFLPSALGGFYMFL-TMIILLQV 377

  Fly   518 IIPISLRVNLD---MGKAFY------SWQMQNDSNIQGTVVRSTTIPEELGRISYVLTDKTGTLT 573
            :|||||.|:::   :|:.|:      .:..:.|.:||   .|:..|.|:||:|.|:.:|||||||
Human   378 LIPISLYVSIELVKLGQVFFLSNDLDLYDEETDLSIQ---CRALNIAEDLGQIQYIFSDKTGTLT 439

  Fly   574 QNEMVFKKIHL--GIVSH-----------DADTFHHIGQMIQKLSGNILQQQQGSLSSSSSG--- 622
            :|:|||::..:  ...||           :.|:........|.||.:....|..:...|..|
Human   440 ENKMVFRRCTIMGSEYSHQENAKRLETPKELDSDGEEWTQYQCLSFSARWAQDPATMRSQKGAQP 504

  Fly   623 ---GDSTKPMMFGNRMRRPEGWRE-------------------------------W--------- 644
               ..|.:..:.|:..:|..|.||                               |
Human   505 LRRSQSARVPIQGHYRQRSMGHRESSQPPVAFSSSIEKDVTPDKNLLTKVRDAALWLETLSDSRP 569

  Fly   645 ------------EAVRALALCHNV----------------------------------------- 656
                        :...||.:|::|
Human   570 AKASLSTTSSIADFFLALTICNSVMVSTTTEPRQRVTIKPSSKALGTSLEKIQQLFQKLKLLSLS 634

  Fly   657 ----------------------TPVSDDEDNRSVSTA--STVTGG-------------NNSPTKS 684
                                  |..||:.|:.||.:.  ||..||             :.|.|..
Human   635 QSFSSTAPSDTDLGESLGANVATTDSDERDDASVCSGGDSTDDGGYRSSMWDQGDILESGSGTSL 699

  Fly   685 VINIEAPGSTD---TEHQYQAASPDEIALVKWTEQVGLTLIARDLNTMTLQVKTPSEDNDILLHY 746
            ...:||| :||   .|..|:|.||||.|||........||::|....:|  |:.|   ....|.:
Human   700 EEALEAP-ATDLARPEFCYEAESPDEAALVHAAHAYSFTLVSRTPEQVT--VRLP---QGTCLTF 758

  Fly   747 QILQLFPFTSESKRMGIIVRESKTGQITFYLKGADVVMSSIVQYNDWLSEESGNM---------- 801
            .:|....|.|..|||.::||...||:|..|.||||.|:..:::  |.......||
Human   759 SLLCTLGFDSVRKRMSVVVRHPLTGEIVVYTKGADSVIMDLLE--DPACVPDINMEKKLRKIRAR 821

  Fly   802 --------AREGLRTLVVAKKVLTEEQYSDFETRYNAARLSITDRVAKVAAVTESLERELELLCL 858
                    ||:|||||.:||||::||.:..:.:....|..|:.:|...:....:.||.:|.||..
Human   822 TQKHLDLYARDGLRTLCIAKKVVSEEDFRRWASFRREAEASLDNRDELLMETAQHLENQLTLLGA 886

  Fly   859 TGVEDRLQENVRPTLELLRNAGVRVWMLTGDKLETACCIAKSSQLIGRNQGLHVLRSVKTRT--- 920
            ||:||||||.|..|:..||.||:::|:|||||.|||..||.|.:|:.:...::.:.:....|
Human   887 TGIEDRLQEGVPDTIATLREAGIQLWVLTGDKQETAVNIAHSCRLLNQTDTVYTINTENQETCES 951

  Fly   921 ---DAHQELNSFRRKQ-------------------------GHALVISGESLEVCLQ-YYRPEFL 956
               .|.:||..||..|                         ...|||.|::|....| ....:||
Human   952 ILNCALEELKQFRELQKPDRKLFGFRLPSKTPSITSEAVVPEAGLVIDGKTLNAIFQGKLEKKFL 1016

  Fly   957 ELATASPAVVCCRCSPTQKAQVVALIQKHTGKRTCAVGDGGNDVSMIQQADAGVGIEGREGRQAS 1021
            ||.....:|:|||.:|.||:.:|.|::......|.::|||.|||||||.||.|:||.|:||.||.
Human  1017 ELTQYCRSVLCCRSTPLQKSMIVKLVRDKLRVMTLSIGDGANDVSMIQAADIGIGISGQEGMQAV 1081

  Fly  1022 LAGDFSIPQFSHIAKLLLIHGRRSYKRSAALSQFVIHRGLIITTLQAVFSAVFYLSSVALYQGFL 1086
            ::.||:|.:|.|:.||||:||...|.|.|.:..:.:::.:....|...:......||..:...:.
Human  1082 MSSDFAITRFKHLKKLLLVHGHWCYSRLARMVVYYLYKNVCYVNLLFWYQFFCGFSSSTMIDYWQ 1146

  Fly  1087 MVGYSTLYTMFP--VFSLVLDQDITSETAVTYPELYKDLSKGRSLSYKTFFIWVLISIYQGGVIM 1149
            |:.::..:|..|  ||. |||:||::||.:..|||||........:..||:|.::.:.||..:..
Human  1147 MIFFNLFFTSLPPLVFG-VLDKDISAETLLALPELYKSGQNSECYNLSTFWISMVDAFYQSLICF 1210

  Fly  1150 YGALILF----VDEFIHIVAISFSALIMTELIMVALTVRTW---HRLMVLAELFSLALYLISL-- 1205
            :...:.:    :|.|.....|:..:| .|.|:..|:.::||   |.:::|...  |..:|:||
Human  1211 FIPYLAYKGSDIDVFTFGTPINTISL-TTILLHQAMEMKTWTIFHGVVLLGSF--LMYFLVSLLY 1272

  Fly  1206 --------AVLHEYFDWEFIWSYDFLWKVSLIT-LVSCLPLYIIKFLRKKC 1247
                    :..:.|:..|...|....:.|..:| :|:.||.|....|:..|
Human  1273 NATCVICNSPTNPYWVMEGQLSNPTFYLVCFLTPVVALLPRYFFLSLQGTC 1323

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31729	NP_609634.1	PhoLip_ATPase_N	227..279	CDD:292826	19/51 (37%)
		ATPase-Plipid	228..1252	CDD:273734	359/1286 (28%)
		E1-E2_ATPase	323..525	CDD:278548	69/233 (30%)
		Cation_ATPase	<704..783	CDD:289987	30/78 (38%)
		HAD_like	<975..1019	CDD:304363	22/43 (51%)
		PhoLip_ATPase_C	1021..1249	CDD:292829	65/247 (26%)
ATP10B	NP_001353581.1	P-type_ATPase_APLT_Dnf-like	68..1213	CDD:319770	332/1169 (28%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	496..541		8/44 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	639..687		10/47 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1346..1397
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165144903
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53737
OrthoDB	1	1.010	-	-		D587717at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.860