DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG31729 and tat-2

DIOPT Version :9

Sequence 1:	NP_609634.1	Gene:	CG31729 / 34736	FlyBaseID:	FBgn0051729	Length:	1256	Species:	Drosophila melanogaster
Sequence 2:	NP_001294447.1	Gene:	tat-2 / 177256	WormBaseID:	WBGene00019166	Length:	1349	Species:	Caenorhabditis elegans

Alignment Length:	1241	Identity:	348/1241 - (28%)
Similarity:	555/1241 - (44%)	Gaps:	242/1241 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   171 PENGSSTVFYQHNRRKSKSRSIGNVCKL--CLCSCWRKWFRPRELRARTVNLGRVNTE-KFPPNE 232
            |:..|||       :.:|....|.:...  |..|...:...|.|.|.| .|....|.: |:..|.
Worm    19 PKEESST-------KSAKKGGGGGMFSWLPCCSSTSNEKNAPTERRLR-ANDREYNAQFKYADNV 75

  Fly   233 IRNQKYNFITFLPLVLFEQFRFFLNLYFLLMALSQFIPDIRIGYPYTYWGPLGFVLMVTICREAV 297
            |:..|||.|||:|..|||||:...|.|||::.:.||||.|.....|:...||..||..:..::..
Worm    76 IKTSKYNIITFIPQNLFEQFQRIANFYFLVLMILQFIPQISSISWYSTAVPLVIVLAFSAIKDGY 140

  Fly   298 DDLRRHQRDHEVNSQKYKRLSSTNISGYEMVPSSKLKVGDVIIVEKNERVPADLILLRTSDRSGS 362
            ||.:||..|..||.:|...:.:.::...:.   |.:||||||.:..|:.|.|||:||.||:..|.
Worm   141 DDAQRHISDRNVNGRKSYVVRNGSLCEEDW---SNVKVGDVIRMMSNQFVAADLLLLSTSEPYGV 202

  Fly   363 VFVRTDQLDGETDWKPRLAVPYTQKLSRDSE-LHSIDASFYVEKPQNDIHSFIATFCMADG---- 422
            .|:.|.:|||||:.|.|.|:..||::..|.: :...|.....|.|.|.:..|.......:.
Worm   203 CFIETMELDGETNLKNRAAIACTQEMGDDLDGITRFDGEIICEPPNNKLDKFNGKLIWNNHEYGV 267

  Fly   423 SEDT----GLSVENTLWANTVVAAGTATGIVIYTGCETRSVMNNSQPRSKVGLLDMEINGLTKVL 483
            :.|.    |..::||.|         ..|:|::.|.:|:.:||:.:.:.|...||..:|.|...:
Worm   268 NNDNILLRGCILKNTRW---------CYGVVVFAGKDTKLMMNSGKTKFKRTSLDRFLNILIVGI 323

  Fly   484 FCAVLGLSLVMMMLKGFGG-----------PW-------------------YRYMFRFVLLFSYI 518
            ...::.:.|:..:|.....           ||                   :...|.:::|.:.:
Worm   324 VLFLIAMCLICTILCAVWEYQTGRYFTIYLPWDDVVPSPEQRGGRQIALIAFLQFFSYIILLNTV 388

  Fly   519 IPISLRVNLDMGKAFYS-W-----QM--QNDSNIQGTVVRSTTIPEELGRISYVLTDKTGTLTQN 575
            :||||.|::::.:..:| |     ||  :|..........:||:.||||::.||.:|||||||:|
Worm   389 VPISLYVSVEIIRFIHSLWINYDTQMYYENGEKSVPAKAHTTTLNEELGQVQYVFSDKTGTLTRN 453

  Fly   576 EMVFKKIHLGIVSHDADTFHHIGQMIQKLSGNILQQQQGSLSSS-SSGGDST-----KPMMFGNR 634
            .|.|.|..:..:|: .|.:.|.|::|:      ...:..||..| :|..:.|     |.::...:
Worm   454 IMTFNKCTINGISY-GDIYDHKGEVIE------TNDKTKSLDFSWNSASEPTFKFFDKNLVDATK 511

  Fly   635 MRRPEGWREWEAVRALALCHNVTPVSDDEDNRSVSTASTVTGGNNSPTKSVINIEAPGSTDTEHQ 699
            .:.||..:.|   |.|||||.|.|..|                                 ..:..
Worm   512 RQVPEIDQFW---RLLALCHTVMPERD---------------------------------KGQLV 540

  Fly   700 YQAASPDEIALVKWTEQVGLTLIARDLNTMTLQVKTPSEDNDILLHYQILQLFPFTSESKRMGII 764
            |||.||||.||.......|....||...::|::|....|.      :::|.:..|.::.|||.:|
Worm   541 YQAQSPDEHALTSAARNFGYVFRARTPQSITIEVMGNEET------HELLAILDFNNDRKRMSVI 599

  Fly   765 VRESKTGQITFYLKGAD-VVMSSIVQYNDWLSEESGN-----MAREGLRTLVVAKKVLTEEQYSD 823
            |: ...|:|..|.|||| ::|..|......:...|.|     .|..|||||.:..|.|....:||
Worm   600 VK-GPDGKIRLYCKGADMMIMQRIHPSTSQIMRTSTNTHLADFANIGLRTLCLGYKDLDPAYFSD 663

  Fly   824 FETRYNAARLSITDRVAKVAAVTESLERELELLCLTGVEDRLQENVRPTLELLRNAGVRVWMLTG 888
            :::|...|..::.||.:.|.|:.|.:|::|.|:..|.:||:||:.|...:..|..|.:::|:|||
Worm   664 WDSRVKKASAAMQDRESAVDALYEEIEKDLILIGATAIEDKLQDGVPEAIARLSEANIKIWVLTG 728

  Fly   889 DKLETACCIAKSSQLIGRNQGLHVLRSVKTRTDAHQEL----NSFRR------------------ 931
            ||.|||..||.|.:|:.......|:...:|.|:...:|    |:|.:
Worm   729 DKTETAINIAYSCRLLTDETKEIVVVDGQTDTEVEVQLKDTRNTFEQILALPSPLGGKPRIEIET 793

  Fly   932 --------------------------------KQGHALVISGESLEVCL-QYYRPEFLELATASP 963
                                            ..|.||||:|:||...| ......|||:|....
Worm   794 IHEESEAISSARSMDRNIVTPDLKSAEMAEHESGGVALVINGDSLAFALGPRLERTFLEVACMCN 858

  Fly   964 AVVCCRCSPTQKAQVVALIQKHTGKRTCAVGDGGNDVSMIQQADAGVGIEGREGRQASLAGDFSI 1028
            ||:|||.:|.||||||.|::::....|.::|||.||||||:.|..||||.|:||.||.||.|:||
Worm   859 AVICCRVTPLQKAQVVDLVKRNKKAVTLSIGDGANDVSMIKTAHIGVGISGQEGMQAVLASDYSI 923

  Fly  1029 PQFSHIAKLLLIHGRRSYKRSAALSQFVIHRGLIITTLQAVFSAVFYLSSVALYQGFLMVGYSTL 1093
            .||.::.:|||:|||.||.|.|...::..::....|.....:|.....|:..::...|:..|:..
Worm   924 GQFKYLERLLLVHGRWSYIRMAKFLRYFFYKNFAFTLTNFWYSFFCGYSAQTVFDAVLIACYNLF 988

  Fly  1094 YTMFPVFSL-VLDQDITSETAVTYPELYKDLSKGRSLSYKTFFIWVLISIYQGGVIMYGALILF- 1156
            :|..||.:: .||||:....::.||:||.........:.:.|    :.|:..|   |:.:|::|
Worm   989 FTALPVLAMGSLDQDVDDHYSLRYPKLYLPGQFNLFFNMRIF----IYSVLHG---MFSSLVIFF 1046

  Fly  1157 ----------------VDEFIHIVAISFSALIMTELIMVALTVRTWHRLMVLAELFSLALYLISL 1205
                            :|::..:...:|:||::.....:|.....|..:.......||.||.:..
Worm  1047 IPYGAFYNAAAASGKDLDDYSALAFTTFTALVVVVTGQIAFDTSYWTAISHFVIWGSLVLYFLVC 1111

  Fly  1206 AVLHEYFDWEFI------WSY----------DFLWKVSLITLVSCLPLYIIKF------------ 1242
            .:|:|:....:|      .||          .|.:.:.::::|..||:.:.:|
Worm  1112 FLLYEWLPVSWIVKTSSSISYGVAFRTMVTPHFWFSILMVSVVLLLPVMLNRFFWLDTHPSFADR 1176

  Fly  1243 --LRKK 1246
              :|||
Worm  1177 LRIRKK 1182

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31729	NP_609634.1	PhoLip_ATPase_N	227..279	CDD:292826	24/51 (47%)
		ATPase-Plipid	228..1252	CDD:273734	333/1181 (28%)
		E1-E2_ATPase	323..525	CDD:278548	61/240 (25%)
		Cation_ATPase	<704..783	CDD:289987	26/79 (33%)
		HAD_like	<975..1019	CDD:304363	24/43 (56%)
		PhoLip_ATPase_C	1021..1249	CDD:292829	62/274 (23%)
tat-2	NP_001294447.1	PhoLip_ATPase_N	60..122	CDD:292826	26/61 (43%)
		ATPase-Plipid	71..1178	CDD:273734	330/1175 (28%)
		Cation_ATPase	526..615	CDD:289987	33/128 (26%)
		R3H	675..738	CDD:294210	25/62 (40%)
		HAD_like	<885..916	CDD:304363	19/30 (63%)
		PhoLip_ATPase_C	916..1172	CDD:292829	59/262 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53737
OrthoDB	1	1.010	-	-		D587717at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.930