DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG31729 and tat-5

DIOPT Version :9

Sequence 1:	NP_609634.1	Gene:	CG31729 / 34736	FlyBaseID:	FBgn0051729	Length:	1256	Species:	Drosophila melanogaster
Sequence 2:	NP_001021457.1	Gene:	tat-5 / 172748	WormBaseID:	WBGene00009498	Length:	1074	Species:	Caenorhabditis elegans

Alignment Length:	1115	Identity:	622/1115 - (55%)
Similarity:	785/1115 - (70%)	Gaps:	100/1115 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly   155 TGDLSNGATHSTTVIDPENGSSTVFYQHNRRKSKSRSIGNVCKLCLCSCWRKWF-RPRELRARTV 218
            |..|.:.|||.:.....:.|....                       .|.|..| |.|.|.:|||
Worm    47 TASLKSNATHFSAASAAKGGMFDF-----------------------RCCRSLFSRRRVLHSRTV 88

  Fly   219 NLG------RVNTEKFPPNEIRNQKYNFITFLPLVLFEQFRFFLNLYFLLMALSQFIPDIRIGYP 277
            .:|      ..|. .|.||.:.|||||..:|:|:|||:||:|||||||||||.|||||.|:||.|
Worm    89 RVGYGPVGHDANV-TFTPNTVCNQKYNIFSFVPIVLFQQFKFFLNLYFLLMACSQFIPAIQIGAP 152

  Fly   278 YTYWGPLGFVLMVTICREAVDDLRRHQRDHEVNSQKYKRLS--STNISGYEMVPSSKLKVGDVII 340
            .||||||||||.:|:.|||.||..|:.||.::||:||::|:  .|.|.    :.|:.::||||||
Worm   153 ITYWGPLGFVLTITLIREAFDDFVRYLRDRDLNSEKYEKLTRDGTRIE----IRSADIEVGDVII 213

  Fly   341 VEKNERVPADLILLRTSDRSGSVFVRTDQLDGETDWKPRLAVPYTQKLSRDSELHSIDASFYVEK 405
            :.|:.|||||::||||:|:||:.|:||||||||||||.|:.||:||.|..::::..::...|.||
Worm   214 MHKDRRVPADVVLLRTTDKSGACFIRTDQLDGETDWKLRIPVPHTQHLPNEADIMELNCEVYAEK 278

  Fly   406 PQNDIHSFIATFCMADGS--EDTGLSVENTLWANTVVAAGTATGIVIYTGCETRSVMNNSQPRSK 468
            ||.|||:|:.|..:.|..  :|..|:|||.||||||||:|||.|||:|||.|||||||.:.|.||
Worm   279 PQKDIHAFVGTLKITDDDNVQDGSLNVENVLWANTVVASGTAVGIVVYTGRETRSVMNTTLPESK 343

  Fly   469 VGLLDMEINGLTKVLFCAVLGLSLVMMMLKGFGGPWYRYMFRFVLLFSYIIPISLRVNLDMGKAF 533
            |||||:|:|.|||:|||.||.||.||:.:||....||||:.||:|||||||||||||||||.|.|
Worm   344 VGLLDLEVNNLTKLLFCFVLVLSSVMVAMKGLDNLWYRYLMRFILLFSYIIPISLRVNLDMAKLF 408

  Fly   534 YSWQMQNDSNIQGTVVRSTTIPEELGRISYVLTDKTGTLTQNEMVFKKIHLGIVSHDADTFHHIG 598
            ||||:..|.:|..||:||:||||||||||::|:|||||||:|||.|||||||.|:..:|.|..:|
Worm   409 YSWQIGRDKHIPETVIRSSTIPEELGRISFLLSDKTGTLTKNEMHFKKIHLGTVAFSSDAFEEVG 473

  Fly   599 QMIQKLSGNILQQQQGSLSSSSSGGDSTKPMMFGNRMRRPEGWREWEAVRALALCHNVTPVSDDE 663
            |       ::.....|.|:..|          |..:::        .||.|:||||||||:.
Worm   474 Q-------HVRSAYAGRLAKHS----------FSAKLQ--------NAVEAIALCHNVTPIF--- 510

  Fly   664 DNRSVSTASTVTGGNNSPTKSVINIEAPGSTDTEHQYQAASPDEIALVKWTEQVGLTLIARDLNT 728
            :|..:|                              ||||||||:|||||||.||:.|.:|||:.
Worm   511 ENGEIS------------------------------YQAASPDEVALVKWTETVGVRLASRDLHA 545

  Fly   729 MTLQVKTPSEDNDILLHYQILQLFPFTSESKRMGIIVRESKTGQITFYLKGADVVMSSIVQYNDW 793
            |:|.|:.|: ...::..:|||.:||||||:|||||||::..|.::|..:||||.|||.:||||||
Worm   546 MSLSVQLPN-GQTLMKQFQILYVFPFTSETKRMGIIVKDETTDEVTLLMKGADTVMSGMVQYNDW 609

  Fly   794 LSEESGNMAREGLRTLVVAKKVLTEEQYSDFETRYNAARLSITDRVAKVA-AVTESLERELELLC 857
            |.||..|||||||||||||:|.|::.:...|:..|:||::||:||...:| .|...|||:|:|||
Worm   610 LDEECSNMAREGLRTLVVARKPLSQAELEAFDRAYHAAKMSISDRSQNMANVVNRMLERDLQLLC 674

  Fly   858 LTGVEDRLQENVRPTLELLRNAGVRVWMLTGDKLETACCIAKSSQLIGRNQGLHVLRSVKTRTDA 922
            |||||||||:.|..:||||||||:::|||||||||||.||||||.|..|:..:||..:|..||||
Worm   675 LTGVEDRLQDQVTTSLELLRNAGIKIWMLTGDKLETAICIAKSSGLFSRSDNIHVFGNVHNRTDA 739

  Fly   923 HQELNSFRRKQGHALVISGESLEVCLQYYRPEFLELATASPAVVCCRCSPTQKAQVVALIQKHTG 987
            |.|||:.|||...|||:.|.:|.||||||..|..||..|..|||||||||.||||:|.|::|:..
Worm   740 HNELNNLRRKTDVALVMPGSALNVCLQYYEAEVAELVCACTAVVCCRCSPEQKAQIVQLLRKYRA 804

  Fly   988 K-RTCAVGDGGNDVSMIQQADAGVGIEGREGRQASLAGDFSIPQFSHIAKLLLIHGRRSYKRSAA 1051
            . |..|:|||||||||||.|.||:||:..||:|||||.||||.||||:.:|||:|||..||||.|
Worm   805 PLRVAAIGDGGNDVSMIQAAHAGIGIDANEGKQASLAADFSITQFSHVCRLLLVHGRFCYKRSCA 869

  Fly  1052 LSQFVIHRGLIITTLQAVFSAVFYLSSVALYQGFLMVGYSTLYTMFPVFSLVLDQDITSETAVTY 1116
            |||||:||||||:|:||:||.|||.:||:||||.|||.|||.|||.||||||:|:|:|:..|:||
Worm   870 LSQFVMHRGLIISTMQAIFSCVFYFASVSLYQGVLMVAYSTCYTMLPVFSLVVDRDVTATNALTY 934

  Fly  1117 PELYKDLSKGRSLSYKTFFIWVLISIYQGGVIMYGALILFVDEFIHIVAISFSALIMTELIMVAL 1181
            |||||:|.||||||||||.||||||:|||.|||||||::|..:|||:|:|||||||:|||||||:
Worm   935 PELYKELGKGRSLSYKTFCIWVLISLYQGAVIMYGALLVFDADFIHVVSISFSALIVTELIMVAM 999

  Fly  1182 TVRTWHRLMVLAELFSLALYLISLAVLHEYFDWEFIWSYDFLWKVSLITLVSCLPLYIIKFLRKK 1246
            ||.|||..|:||:..||.||:|||.:..:|||.:|:.|:.|:.|.:.||.||||||||:|.||:|
Worm  1000 TVHTWHWAMLLAQALSLGLYMISLILFDQYFDRQFVLSWVFISKTTAITAVSCLPLYIVKALRRK 1064

  Fly  1247 CSPPSYLKLS 1256
            .|||||.|::
Worm  1065 FSPPSYAKVN 1074

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31729	NP_609634.1	PhoLip_ATPase_N	227..279	CDD:292826	35/51 (69%)
		ATPase-Plipid	228..1252	CDD:273734	602/1029 (59%)
		E1-E2_ATPase	323..525	CDD:278548	120/203 (59%)
		Cation_ATPase	<704..783	CDD:289987	43/78 (55%)
		HAD_like	<975..1019	CDD:304363	26/44 (59%)
		PhoLip_ATPase_C	1021..1249	CDD:292829	155/227 (68%)
tat-5	NP_001021457.1	ATPase-Plipid	103..1073	CDD:273734	604/1032 (59%)
		PhoLip_ATPase_N	<103..154	CDD:292826	35/50 (70%)
		E1-E2_ATPase	161..400	CDD:278548	139/242 (57%)
		Cation_ATPase	502..600	CDD:289987	56/131 (43%)
		HAD_like	<792..834	CDD:304363	24/41 (59%)
		PhoLip_ATPase_C	839..1067	CDD:292829	155/227 (68%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160166395
Domainoid	1	1.000	320	1.000	Domainoid score	I662
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H21915
Inparanoid	1	1.050	1177	1.000	Inparanoid score	I102
Isobase	1	0.950	-	0	Normalized mean entropy	S481
OMA	1	1.010	-	-		QHG53737
OrthoDB	1	1.010	-	-		D587717at2759
OrthoFinder	1	1.000	-	-		FOG0002153
OrthoInspector	1	1.000	-	-		otm14303
orthoMCL	1	0.900	-	-		OOG6_101160
Panther	1	1.100	-	-	LDO	PTHR24092
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5489
SonicParanoid	1	1.000	-	-		X1437
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	16	15.890