DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG31729 and ATP8B3

DIOPT Version :9

Sequence 1:NP_609634.1 Gene:CG31729 / 34736 FlyBaseID:FBgn0051729 Length:1256 Species:Drosophila melanogaster
Sequence 2:XP_006722717.1 Gene:ATP8B3 / 148229 HGNCID:13535 Length:1310 Species:Homo sapiens


Alignment Length:1304 Identity:349/1304 - (26%)
Similarity:568/1304 - (43%) Gaps:287/1304 - (22%)


- Green bases have known domain annotations that are detailed below.


  Fly   120 GAGSIGGGGGGSGSATGIKVTTGDGSV----AASGGSA------ATGDLSNGATHSTTVIDPENG 174
            |:|..|..||.:....|:..:.|.|:.    .|..|.|      ..|..|.|:......:..|:.
Human    37 GSGPAGIRGGETVIRAGMGDSPGRGAPERRHKAQPGRARKYEWRPEGPTSMGSLGQREDLQDEDR 101

  Fly   175 SSTVFYQHNRRKSKSRSIGNVCKLCLCSCWRKWFRPRELRARTVNLGRVNTEKFPPNEIRNQKYN 239
            :|...:   :.::.:|:.....|..:..||::                   :|:..|.||..|||
Human   102 NSAFTW---KVQANNRAYNGQFKEKVILCWQR-------------------KKYKTNVIRTAKYN 144

  Fly   240 FITFLPLVLFEQFRFFLNLYFLLMALSQFIPDIRIGYPYTYWGPLGFVLMVTICREAVDDLRRHQ 304
            |.:||||.|:|||....||:||::.:.|.||||.....::...|:..:|.:...|:.|||:.||:
Human   145 FYSFLPLNLYEQFHRVSNLFFLIIIILQSIPDISTLPWFSLSTPMVCLLFIRATRDLVDDMGRHK 209

  Fly   305 RDHEVNSQKYKRLSSTNISGYEMVPSSKLKVGDVIIVEKNERVPADLILLRTSDRSGSVFVRTDQ 369
            .|..:|::..:.|..   ..::......|.||||:.:.|:..||||::||.:::.|...:|.|..
Human   210 SDRAINNRPCQILMG---KSFKQKKWQDLCVGDVVCLRKDNIVPADMLLLASTEPSSLCYVETVD 271

  Fly   370 LDGETDWKPRLAVPYTQK-LSRDSELHSIDASFYVEKPQNDIHSFIATFCMADGSEDTGLSVENT 433
            :||||:.|.|.|:..|.| |:...::.|...:...|.|.:.:|.|:.  |:....:...|.:.|.
Human   272 IDGETNLKFRQALMVTHKELATIKKMASFQGTVTCEAPNSRMHHFVG--CLEWNDKKYSLDIGNL 334

  Fly   434 LWANTVVA-AGTATGIVIYTGCETRSVMNNSQPRSKVGLLDMEINGLTKVLFCAVLGLSLVMMML 497
            |.....:. ..|..|:|||.|.:|:.:.|..:...|...||:.:|.|..|:|.:|:.:.||:...
Human   335 LLRGCRIRNTDTCYGLVIYAGFDTKIMKNCGKIHLKRTKLDLLMNKLVVVIFISVVLVCLVLAFG 399

  Fly   498 KGFGGPWYR----YM----------------FRFVLLFSYIIPISLRVNLDM----GKAFYSWQM 538
            .||....::    |:                :.|::|.|..||:|:.:..:.    ...|..|.:
Human   400 FGFSVKEFKDHHYYLSGVHGSSVAAESFFVFWSFLILLSVTIPMSMFILSEFIYLGNSVFIDWDV 464

  Fly   539 QNDSNIQG--TVVRSTTIPEELGRISYVLTDKTGTLTQNEMVFKKIHLGIVSHDADTFHHIGQMI 601
            |.....|.  ...|||::.:.||::.|:.:|||||||||.:.|.|.                   
Human   465 QMYYKPQDVPAKARSTSLNDHLGQVEYIFSDKTGTLTQNILTFNKC------------------- 510

  Fly   602 QKLSGNILQQQQGSLSSSSSGGDS---TKP--------------MMFGN-------RMRRPEGWR 642
             .:||.:.            |.||   |:|              ::|.|       |....|..|
Human   511 -CISGRVY------------GPDSEATTRPKENPYLWNKFADGKLLFHNAALLHLVRTNGDEAVR 562

  Fly   643 E-WEAVRALALCHNVTPVSDDEDNRSVSTASTVTGGNNSPTKSVINIEAPGSTDTEHQYQAASPD 706
            | |   |.||:||                             :|:..|:|.....:..|||||||
Human   563 EFW---RLLAICH-----------------------------TVMVRESPRERPDQLLYQAASPD 595

  Fly   707 EIALVKWTEQVGLTLIARDLNTMTLQVKTPSEDNDILLHYQILQLFPFTSESKRMGIIVRESKTG 771
            |.|||......|...::|..:|:|  :....|:.    .||:|.:..|.|..|||.::||:.: |
Human   596 EGALVTAARNFGYVFLSRTQDTVT--IMELGEER----VYQVLAIMDFNSTRKRMSVLVRKPE-G 653

  Fly   772 QITFYLKGADVVMSSIVQYN---DWLSEES-GNMAREGLRTLVVAKKVLTEEQYSDFETRYNAAR 832
            .|..|.||||.|:...:...   ::.:||: ...|:|.||||.:|.:.:.|:.|.|::.|:..|.
Human   654 AICLYTKGADTVIFERLHRRGAMEFATEEALAAFAQETLRTLCLAYREVAEDIYEDWQQRHQEAS 718

  Fly   833 LSITDRVAKVAAVTESLERELELLCLTGVEDRLQENVRPTLELLRNAGVRVWMLTGDKLETACCI 897
            |.:.:|...:..|...:|::|.||..|.:|||||:.|..|::.|:.:.:::|:|||||.|||..|
Human   719 LLLQNRAQALQQVYNEMEQDLRLLGATAIEDRLQDGVPETIKCLKKSNIKIWVLTGDKQETAVNI 783

  Fly   898 AKSSQLIGRNQGLHVLRSVKTRTDAHQE-LNSFRRKQG-----HALVISGESLEVCLQYYRPE-- 954
            ..:.:|:..|..:...:.:....:.:.| .|:...::.     .||||:|:.|:..|...|.|  
Human   784 GFACELLSENMLILEEKEISRILETYWENSNNLLTRESLSQVKLALVINGDFLDKLLVSLRKEPR 848

  Fly   955 ------------------------------------------------------------FLELA 959
                                                                        |::||
Human   849 ALAQNVNMDEAWQELGQSRRDFLYARRLSLLCRRFGLPLAAPPAQDSRARRSSEVLQERAFVDLA 913

  Fly   960 TASPAVVCCRCSPTQKAQVVALIQKHTGKRTCAVGDGGNDVSMIQQADAGVGIEGREGRQASLAG 1024
            :...||:|||.:|.|||.:|||::|:....|.|:|||.||::||:.||.|||:.|:||.||....
Human   914 SKCQAVICCRVTPKQKALIVALVKKYHQVVTLAIGDGANDINMIKTADVGVGLAGQEGMQAVQNS 978

  Fly  1025 DFSIPQFSHIAKLLLIHGRRSYKRSAALSQFVIHRGLIITTLQAVFSAVFYLSSVALYQGFLMVG 1089
            ||.:.||..:.:|||:|||.||.|.....::..::.:....:|..|:.....:...||:|:.:..
Human   979 DFVLGQFCFLQRLLLVHGRWSYVRICKFLRYFFYKSMASMMVQVWFACYNGFTGQPLYEGWFLAL 1043

  Fly  1090 YSTLYTMFPVFSL-VLDQDITSETAVTYPELYKDLSKGRSLSYKTFFIWVLISIYQGGVIMYGAL 1153
            ::.||:..||..: :.:||:::|.::..||||....|....:|     ||.:.....||..  :|
Human  1044 FNLLYSTLPVLYIGLFEQDVSAEQSLEKPELYVVGQKDELFNY-----WVFVQAIAHGVTT--SL 1101

  Fly  1154 ILFV------------------DEFIHIVAISFSALIMTELIMVALTVRTWHRLMVLAELFSLAL 1200
            :.|.                  ..|..:||:|....|..|:|::   ::.|..|.|...|.||..
Human  1102 VNFFMTLWISRDTAGPASFSDHQSFAVVVALSCLLSITMEVILI---IKYWTALCVATILLSLGF 1163

  Fly  1201 YLISLAVLHEYFDWEFIWS---YDFLW---------KVSLITLVS-------CLPLYII----KF 1242
            |.|.......:  |.|..|   :.||:         .:.|:.|:|       .|.|.:|    |.
Human  1164 YAIMTTTTQSF--WLFRVSPTTFPFLYADLSVMSSPSILLVVLLSVSINTFPVLALRVIFPALKE 1226

  Fly  1243 LRKK 1246
            ||.|
Human  1227 LRAK 1230

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG31729NP_609634.1 PhoLip_ATPase_N 227..279 CDD:292826 25/51 (49%)
ATPase-Plipid 228..1252 CDD:273734 328/1186 (28%)
E1-E2_ATPase 323..525 CDD:278548 61/223 (27%)
Cation_ATPase <704..783 CDD:289987 29/78 (37%)
HAD_like <975..1019 CDD:304363 23/43 (53%)
PhoLip_ATPase_C 1021..1249 CDD:292829 67/268 (25%)
ATP8B3XP_006722717.1 PhoLip_ATPase_N 108..184 CDD:292826 29/94 (31%)
ATPase-Plipid 133..1220 CDD:273734 323/1174 (28%)
Cation_ATPase <593..669 CDD:289987 30/82 (37%)
HAD_like <931..975 CDD:304363 22/43 (51%)
PhoLip_ATPase_C 975..1220 CDD:292829 62/256 (24%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165144904
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG53737
OrthoDB 1 1.010 - - D587717at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
43.860

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