DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG31729 and AgaP_AGAP008184

DIOPT Version :9

Sequence 1:	NP_609634.1	Gene:	CG31729 / 34736	FlyBaseID:	FBgn0051729	Length:	1256	Species:	Drosophila melanogaster
Sequence 2:	XP_317283.4	Gene:	AgaP_AGAP008184 / 1277786	VectorBaseID:	AGAP008184	Length:	1066	Species:	Anopheles gambiae

Alignment Length:	1075	Identity:	817/1075 - (76%)
Similarity:	924/1075 - (85%)	Gaps:	27/1075 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly   199 CLCSCWRKWFRPRELRARTVNLGRVNTEKFPPNEIRNQKYNFITFLPLVLFEQFRFFLNLYFLLM 263
            |.|..||||...:||:.||:.:||..||||||||||||||||.||||||||||||||||||||:|
Mosquito     2 CWCWAWRKWCASKELKPRTIYIGRPLTEKFPPNEIRNQKYNFFTFLPLVLFEQFRFFLNLYFLIM 66

  Fly   264 ALSQFIPDIRIGYPYTYWGPLGFVLMVTICREAVDDLRRHQRDHEVNSQKYKRLSSTNISGYEMV 328
            |:|||||:|||||.|||||||||||.||||||||||||||:||.|||||||||..|.: ...|.|
Mosquito    67 AVSQFIPEIRIGYLYTYWGPLGFVLAVTICREAVDDLRRHKRDREVNSQKYKRFVSAD-KPPESV 130

  Fly   329 PSSKLKVGDVIIVEKNERVPADLILLRTSDRSGSVFVRTDQLDGETDWKPRLAVPYTQKLSRDSE 393
            .||||:|||:|:|||:||||||||||||||:||:||||||.||||||||.|||||.||||:...|
Mosquito   131 SSSKLRVGDIIMVEKDERVPADLILLRTSDKSGAVFVRTDMLDGETDWKLRLAVPATQKLASHGE 195

  Fly   394 LHSIDASFYVEKPQNDIHSFIATFCMADGSEDTGLSVENTLWANTVVAAGTATGIVIYTGCETRS 458
            |.:::||.||||||.|||:||.|:....|:||.||:||||||||||||:|||.|||||||.||||
Mosquito   196 LLTVNASLYVEKPQRDIHTFIGTYSKHGGTEDEGLNVENTLWANTVVASGTAVGIVIYTGSETRS 260

  Fly   459 VMNNSQPRSKVGLLDMEINGLTKVLFCAVLGLSLVMMMLKGFGGPWYRYMFRFVLLFSYIIPISL 523
            |||||||||||||||:|||.|||||||||:|||..||.||||.||||||||||||||||||||||
Mosquito   261 VMNNSQPRSKVGLLDLEINNLTKVLFCAVIGLSFAMMCLKGFNGPWYRYMFRFVLLFSYIIPISL 325

  Fly   524 RVNLDMGKAFYSWQMQNDSNIQGTVVRSTTIPEELGRISYVLTDKTGTLTQNEMVFKKIHLGIVS 588
            ||||||||||||||:|||..|:|||||||||||||||:||:|||||||||||||:|||||:|..:
Mosquito   326 RVNLDMGKAFYSWQIQNDDEIKGTVVRSTTIPEELGRMSYLLTDKTGTLTQNEMIFKKIHVGTAA 390

  Fly   589 HDADTFHHIGQMIQKLSGNILQQQQGSLSSSSSGGDSTKPMMFGNRMRRPEGWREWEAVRALALC 653
            :..|||..:...||.:        .|:||:.:..........:..|:|:|:|||.||:|:|||||
Mosquito   391 YGRDTFPMVSAAIQSV--------YGTLSAPADASPEDHGSEYQPRLRKPDGWRIWESVKALALC 447

  Fly   654 HNVTPVSDDED-NRSVSTASTVTGGNNSPTKSVINIEA----PGST---DTEHQYQAASPDEIAL 710
            ||||||.:..: |....:.|:.:....||.:| |::|:    |.::   .||..|||:|||||||
Mosquito   448 HNVTPVYESNNGNGGSGSISSTSDRRQSPARS-ISVESQAGEPSTSKPATTEKTYQASSPDEIAL 511

  Fly   711 VKWTEQVGLTLIARDLNTMTLQVK---------TPSEDNDILLHYQILQLFPFTSESKRMGIIVR 766
            |||||.|||||:.||||.||||::         :.:|:..|...|||||.||||||:||||||||
Mosquito   512 VKWTESVGLTLVQRDLNHMTLQIRDATHEARGTSMNENASINTTYQILQTFPFTSENKRMGIIVR 576

  Fly   767 ESKTGQITFYLKGADVVMSSIVQYNDWLSEESGNMAREGLRTLVVAKKVLTEEQYSDFETRYNAA 831
            |...|:|||||||||||||.||||||||:|||||||||||||||||||||:||||:||..|||||
Mosquito   577 ELNGGEITFYLKGADVVMSGIVQYNDWLAEESGNMAREGLRTLVVAKKVLSEEQYNDFVMRYNAA 641

  Fly   832 RLSITDRVAKVAAVTESLERELELLCLTGVEDRLQENVRPTLELLRNAGVRVWMLTGDKLETACC 896
            ::|:||||||||||.||||||:|||||||||||||:.||||||||||||:::|||||||||||.|
Mosquito   642 KVSVTDRVAKVAAVIESLEREMELLCLTGVEDRLQDRVRPTLELLRNAGIKIWMLTGDKLETATC 706

  Fly   897 IAKSSQLIGRNQGLHVLRSVKTRTDAHQELNSFRRKQGHALVISGESLEVCLQYYRPEFLELATA 961
            |||||.|:||||.:|||:||.||||||.|||.|||||..|||:||||||||||||:|||:|||||
Mosquito   707 IAKSSHLVGRNQSIHVLKSVLTRTDAHLELNQFRRKQDCALVVSGESLEVCLQYYQPEFMELATA 771

  Fly   962 SPAVVCCRCSPTQKAQVVALIQKHTGKRTCAVGDGGNDVSMIQQADAGVGIEGREGRQASLAGDF 1026
            .|||||||||||||||||:||||::.||||||||||||||||||||||:|||||||:||||||||
Mosquito   772 CPAVVCCRCSPTQKAQVVSLIQKYSKKRTCAVGDGGNDVSMIQQADAGIGIEGREGKQASLAGDF 836

  Fly  1027 SIPQFSHIAKLLLIHGRRSYKRSAALSQFVIHRGLIITTLQAVFSAVFYLSSVALYQGFLMVGYS 1091
            |||||||||:||::|||||||||||||||||||||||:|:||||||||||||||||||||||||:
Mosquito   837 SIPQFSHIARLLIVHGRRSYKRSAALSQFVIHRGLIISTMQAVFSAVFYLSSVALYQGFLMVGYA 901

  Fly  1092 TLYTMFPVFSLVLDQDITSETAVTYPELYKDLSKGRSLSYKTFFIWVLISIYQGGVIMYGALILF 1156
            |||||||||||||||||::..|:|||||||:|||||||||||||:||||||||||||||||||||
Mosquito   902 TLYTMFPVFSLVLDQDISANIAITYPELYKELSKGRSLSYKTFFMWVLISIYQGGVIMYGALILF 966

  Fly  1157 VDEFIHIVAISFSALIMTELIMVALTVRTWHRLMVLAELFSLALYLISLAVLHEYFDWEFIWSYD 1221
            .|||||||||||||||:|||||||||:||||:|||:||||||.||::||||||||||||||||:|
Mosquito   967 EDEFIHIVAISFSALILTELIMVALTIRTWHKLMVIAELFSLVLYIVSLAVLHEYFDWEFIWSWD 1031

  Fly  1222 FLWKVSLITLVSCLPLYIIKFLRKKCSPPSYLKLS 1256
            |||||.:|||||||||||:||||||.|||||.|||
Mosquito  1032 FLWKVLVITLVSCLPLYILKFLRKKFSPPSYSKLS 1066

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31729	NP_609634.1	PhoLip_ATPase_N	227..279	CDD:292826	46/51 (90%)
		ATPase-Plipid	228..1252	CDD:273734	797/1040 (77%)
		E1-E2_ATPase	323..525	CDD:278548	157/201 (78%)
		Cation_ATPase	<704..783	CDD:289987	57/87 (66%)
		HAD_like	<975..1019	CDD:304363	38/43 (88%)
		PhoLip_ATPase_C	1021..1249	CDD:292829	201/227 (89%)
AgaP_AGAP008184	XP_317283.4	PhoLip_ATPase_N	20..82	CDD:292826	51/61 (84%)
		ATPase-Plipid	31..1065	CDD:273734	799/1043 (77%)
		E1-E2_ATPase	128..327	CDD:278548	157/198 (79%)
		Cation_ATPase	<505..593	CDD:289987	57/87 (66%)
		HAD_like	<787..826	CDD:304363	33/38 (87%)
		PhoLip_ATPase_C	831..1059	CDD:292829	201/227 (89%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	415	1.000	Domainoid score	I1984
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H21915
Inparanoid	1	1.050	1609	1.000	Inparanoid score	I290
OMA	1	1.010	-	-		QHG53737
OrthoDB	1	1.010	-	-		D11922at33392
OrthoFinder	1	1.000	-	-		FOG0002153
OrthoInspector	1	1.000	-	-		oto109124
Panther	1	1.100	-	-	LDO	PTHR24092
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1437
TreeFam	0	0.000	Not matched by this tool.
	11	11.080