DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG31729 and Atp10a

DIOPT Version :9

Sequence 1:	NP_609634.1	Gene:	CG31729 / 34736	FlyBaseID:	FBgn0051729	Length:	1256	Species:	Drosophila melanogaster
Sequence 2:	NP_033858.2	Gene:	Atp10a / 11982	MGIID:	1330809	Length:	1508	Species:	Mus musculus

Alignment Length:	1321	Identity:	351/1321 - (26%)
Similarity:	555/1321 - (42%)	Gaps:	339/1321 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   207 WFRPR----ELRARTVN------LGRVNT----------------EKFPPNEIRNQKYNFITFLP 245
            |.|||    |.|.|||.      ||..::                :....|.::..||..::|||
Mouse    16 WRRPRRRRWEGRTRTVRSNLLPPLGTEDSTIGAPKGERLLMRGCIQHLADNRLKTTKYTLLSFLP 80

  Fly   246 LVLFEQFRFFLNLYFLLMALSQFIPDIRIGYPYTYWGPLGFVLMVTICREAVDDLRRHQRDHEVN 310
            ..|||||....|:||:.:||..|:|.:....|.....|:.|:|.||..::..:|..||:.|||:|
Mouse    81 KNLFEQFHRLANVYFVFIALLNFVPAVNAFQPGLALAPVLFILAVTAIKDLWEDYSRHRSDHEIN 145

  Fly   311 ---SQKYKRLSSTNISGYEMVPSSKLKVGDVIIVEKNERVPADLILLRTSDRSGSVFVRTDQLDG 372
               ...:.|.....::.|    ..:::|||.:.:..||.:|||::||.:||..|...:.|..|||
Mouse   146 HLGCLVFSREEKKYVNRY----WKEIRVGDFVRLCCNEIIPADILLLSSSDPDGLCHIETANLDG 206

  Fly   373 ETDWKPRLAVPYTQKLSRDSELHSIDASFYVEKPQNDIHSFIATFCMADGSEDTGLSVENTLWAN 437
            ||:.|.|..|....:|..:....:..:....|||.||:..| ..:.|....|..||..||.|...
Mouse   207 ETNLKRRQVVRGFSELVSEFNPLTFTSVIECEKPNNDLSRF-RGYIMHSNGEKAGLHKENLLLRG 270

  Fly   438 -TVVAAGTATGIVIYTGCETRSVMNNSQPRSKVGLLDMEINGLTKVLFCAVLGLSLVMMMLKGFG 501
             |:.......|||||.|.||::::|||.||.|...|:.::|  ..||:|.:|.:.:.:....|.
Mouse   271 CTIRNTEAVAGIVIYAGHETKALLNNSGPRYKRSQLERQMN--CDVLWCVLLLVCISLFSAVGH- 332

  Fly   502 GPWYR---------------------------YMFRFVLLFSYIIPISLRVNLDMGKA----FYS 535
            |.|.|                           ..|..:::...:|||||.|::::.|.    |.:
Mouse   333 GLWVRRYQEKKALFDVPESDGSSLSPATAAVYSFFTMIIVLQVLIPISLYVSIEIVKVCQVYFIN 397

  Fly   536 -----WQMQNDSNIQGTVVRSTTIPEELGRISYVLTDKTGTLTQNEMVFKKIHL-GI-VSHDAD- 592
                 :..:.||.:|   .|:..|.|:||:|.|:.:|||||||:|:|||::..: || .||||:
Mouse   398 QDIELYDEETDSQLQ---CRALNITEDLGQIKYIFSDKTGTLTENKMVFRRCTVSGIEYSHDANA 459

  Fly   593 ---------------------TFHHIGQ--------MIQKLSGNILQQQQGSLSSSSSGGDSTKP 628
                                 |..|.|.        |..|.......::.||.:.:......:|.
Mouse   460 QRLARYQEADSEEEEVVSKVGTISHRGSTGSHQSIWMTHKTQSIKSHRRTGSRAEAKRASMLSKH 524

  Fly   629 MMFGNRMRR---------------------------------PEGWREWEAVRALALCHNVTPVS 660
            ..|.:.|.:                                 ||....::...||.:|:.|...|
Mouse   525 TAFSSPMEKDITPDPKLLEKVSECDRFLAIARHQEHPLAHLSPELSDVFDFFIALTICNTVVVTS 589

  Fly   661 DDEDNRSV-------STASTVTG-----------------GNNSPTKS----------------- 684
            .|:..:.|       |...|:..                 ||.|.:||
Mouse   590 PDQPRQKVRVRFELKSPVKTIEDFLRRFTPSRLASGCSSIGNLSTSKSSHKSGSAFLPSLSQDSM 654

  Fly   685 VINIE------APG--------------------STDT------------EHQYQAASPDEIALV 711
            ::.:|      ||.                    :||.            |.:|:|.||||.|||
Mouse   655 LLGLEEKLGQTAPSIASNGYASQAGQEESWASECTTDQKCPGEQREQQEGELRYEAESPDEAALV 719

  Fly   712 KWTEQVGLTLIARDLNTMTLQVKTPSEDNDILLHYQILQLFPFTSESKRMGIIVRESKTGQITFY 776
            .........|:.|..:.:::::.....     |.:::|....|.|..|||.:::|...|.:|..|
Mouse   720 YAARAYNCALVDRLHDQVSVELPHLGR-----LTFELLHTLGFDSIRKRMSVVIRHPLTDEINVY 779

  Fly   777 LKGADVVMSSIV----------QYNDWLSEESGN----MAREGLRTLVVAKKVLTEEQYSDFETR 827
            .||||.|:..::          ::...:..::.|    .|.||||||.:||:||::|:|:.:...
Mouse   780 TKGADSVVMDLLLPCSSDDARGRHQKKIRSKTQNYLNLYAVEGLRTLCIAKRVLSKEEYACWLQS 844

  Fly   828 YNAARLSITDRVAKVAAVTESLERELELLCLTGVEDRLQENVRPTLELLRNAGVRVWMLTGDKLE 892
            :..|..|:..|...:......||..|.||..||:||||||.|..|:..||.||:::|:|||||.|
Mouse   845 HIEAEASVESREELLFQSAVRLETNLHLLGATGIEDRLQEGVPETIAKLRQAGLQIWVLTGDKQE 909

  Fly   893 TACCIAKSSQLIGRNQGLHVLRS-----------------------------------------V 916
            ||..||.:.:|:...:.:..|.:                                         |
Mouse   910 TAINIAYACKLLDHGEEVITLNADSQEACAALLDQCLSYVQSRNPRSTLQNSESNLSVGFSFNPV 974

  Fly   917 KTRTDAHQELNSFRRKQGHALVISGESLEVCLQ-YYRPEFLELATASPAVVCCRCSPTQKAQVVA 980
            .|.|||         ....:|||.|.||...|: ....:||.||....:|:|||.:|.||:.||.
Mouse   975 STSTDA---------SPSPSLVIDGRSLAYALEKSLEDKFLFLAKQCRSVLCCRSTPLQKSMVVK 1030

  Fly   981 LIQKHTGKRTCAVGDGGNDVSMIQQADAGVGIEGREGRQASLAGDFSIPQFSHIAKLLLIHGRRS 1045
            |::......|.|:|||.|||||||.||.||||.|:||.||.:|.||::|:|.::.:||::||...
Mouse  1031 LVRSKLKAMTLAIGDGANDVSMIQVADVGVGISGQEGMQAVMASDFAVPRFRYLERLLIVHGHWC 1095

  Fly  1046 YKRSAALSQFVIHRGLIITTLQAVFSAVFY--LSSVALYQGFLMVGYSTLYTMFP-VFSLVLDQD 1107
            |.|.|.:..:..::..:...|  :|...||  .|:.|:...:.::.::.|::..| :.:.|||:|
Mouse  1096 YSRLANMVLYFFYKNTMFVGL--LFWFQFYCGFSASAMIDQWYLIFFNLLFSSLPQLVTGVLDKD 1158

  Fly  1108 ITSETAVTYPELYKDLSKGRSLSYKTFFIWVLISIYQGGVIMYGALILFVDEFIH-------IVA 1165
            :.::..:..|:|||..........:.|::.::.:.:|..|..:...:.:.|..:.       :.|
Mouse  1159 VPADMLLREPQLYKSGQNMEEYRPRAFWLNMVDAAFQSLVCFFIPYLAYYDSDVDVFTWGTPVTA 1223

  Fly  1166 ISFSALIMTELIMVALTVRTWHRLMVLAELFSLALYLISLAVLHEYFDWEFIWSYDFLWKVSLIT 1230
            |:    :.|.|:.:.:..:||..|..||..||..|:                      :.|:||.
Mouse  1224 IA----LFTFLLHLGIETKTWTWLNWLACGFSTFLF----------------------FSVALIY 1262

  Fly  1231 LVSCLPLYIIKFLRKKCSPPS 1251
            ..||          ..|.|||
Mouse  1263 NTSC----------ATCYPPS 1273

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31729	NP_609634.1	PhoLip_ATPase_N	227..279	CDD:292826	19/51 (37%)
		ATPase-Plipid	228..1252	CDD:273734	340/1274 (27%)
		E1-E2_ATPase	323..525	CDD:278548	68/229 (30%)
		Cation_ATPase	<704..783	CDD:289987	24/78 (31%)
		HAD_like	<975..1019	CDD:304363	25/43 (58%)
		PhoLip_ATPase_C	1021..1249	CDD:292829	50/237 (21%)
Atp10a	NP_033858.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..23		4/6 (67%)
		P-type_ATPase_APLT_Dnf-like	65..1203	CDD:319770	318/1164 (27%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	680..705		2/24 (8%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1334..1354
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1407..1436
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1481..1508
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167835009
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53737
OrthoDB	1	1.010	-	-		D587717at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.950