Protein Alignment CG31729 and ATP8A1

DIOPT Version :9

• Sequence 1: NP_609634.1
• Gene: CG31729 / 34736
• FlyBaseID: FBgn0051729
• Length: 1256
• Species: Drosophila melanogaster
• Sequence 2: XP_011511917.1
• Gene: ATP8A1 / 10396
• HGNCID: 13531
• Length: 1171
• Species: Homo sapiens
• Alignment Length: 1091
• Identity: 317/1091 - (29%)
• Similarity: 522/1091 - (47%)
• Gaps: 173/1091 - (15%)

  Fly   216 RTVNLGRVNTEKFPPNEIRNQKYNFITFLPLVLFEQFRFFLNLYFLLMALSQFIPDIRIGYPYTY 280
            ||:.:.:....||..|.:...|||.|||||..|:.|||...|.:||.:||.|.|||:.....||.
Human    37 RTIFINQPQLTKFCNNHVSTAKYNIITFLPRFLYSQFRRAANSFFLFIALLQQIPDVSPTGRYTT 101

  Fly   281 WGPLGFVLMVTICREAVDDLRRHQRDHEVNSQKYKRLSSTNISGYEMVPSSKLKVGDVIIVEKNE 345
            ..||.|:|.|...:|.::|::||:.|:.||.::.:.|.:   ..:|:|...|:.|||::|::..|
Human   102 LVPLLFILAVAAIKEIIEDIKRHKADNAVNKKQTQVLRN---GAWEIVHWEKVNVGDIVIIKGKE 163

  Fly   346 RVPADLILLRTSDRSGSVFVRTDQLDGETDWKPRLAVPYTQKLSRDSELHSIDASFYVEKPQNDI 410
            .:|||.:||.:|:.....::.|..|||||:.|.|..:|.|..:.....|..|......|.|...:
Human   164 YIPADTVLLSSSEPQAMCYIETSNLDGETNLKIRQGLPATSDIKDVDSLMRISGRIECESPNRHL 228

  Fly   411 HSFIATFCM---------ADGSEDTGLSVENTLWANTVVAAGTATGIVIYTGCETRSVMNNSQPR 466
            :.|:....:         ||.....|..:.||.|.:         |||:|||.:|:.:.|::.|.
Human   229 YDFVGNIRLDGHGTVPLGADQILLRGAQLRNTQWVH---------GIVVYTGHDTKLMQNSTSPP 284

  Fly   467 SKVGLLDMEINGLTKVLFCAVLGLSLVMMM------LKGFGGPWYRYM------------FRFVL 513
            .|:..::...|....:|||.::.:|||..:      .:..|..||..:            ..|::
Human   285 LKLSNVERITNVQILILFCILIAMSLVCSVGSAIWNRRHSGKDWYLNLNYGGASNFGLNFLTFII 349

  Fly   514 LFSYIIPISLRVNLDMGK----AFYSWQMQNDSNIQGT----VVRSTTIPEELGRISYVLTDKTG 570
            ||:.:|||||.|.|::.|    .|.:|.:  |.:.:.|    :.|::.:.||||::.|:.:||||
Human   350 LFNNLIPISLLVTLEVVKFTQAYFINWDL--DMHYEPTDTAAMARTSNLNEELGQVKYIFSDKTG 412

  Fly   571 TLTQNEMVFKKIHLGIVSHDADTFHHIGQMIQKLSGNILQQQQGSLSSSSSGGDSTKPMMFGNRM 635
            |||.|.|.|||..:..|::                                 |...:|..:|
Human   413 TLTCNVMQFKKCTIAGVAY---------------------------------GHVPEPEDYG--- 441

  Fly   636 RRPEGWREWEAVRALALCHNVTPVSDDEDNRSVSTASTVTG-GNNSPTKSVI----------NIE 689
            ..|:.|:.                |...|.::.|.:|.:.. .||.||..:|          :..
Human   442 CSPDEWQN----------------SQFGDEKTFSDSSLLENLQNNHPTAPIICEFLTMMAVCHTA 490

  Fly   690 APGSTDTEHQYQAASPDEIALVKWTEQVGLTLIARDLNTMTLQVKTPSEDNDILLHYQILQLFPF 754
            .|.....:..||||||||.|||:..:|:......|..:::.:......|      .|::|.:..|
Human   491 VPEREGDKIIYQAASPDEGALVRAAKQLNFVFTGRTPDSVIIDSLGQEE------RYELLNVLEF 549

  Fly   755 TSESKRMGIIVRESKTGQITFYLKGADVV----MSSIVQYNDWLSEESGNMAREGLRTLVVAKKV 815
            ||..|||.:||| :.:|::..|.||||.|    ::...:|.:...:.....|.||||||..|...
Human   550 TSARKRMSVIVR-TPSGKLRLYCKGADTVIYDRLAETSKYKEITLKHLEQFATEGLRTLCFAVAE 613

  Fly   816 LTEEQYSDFETRYNAARLSITDRVAKVAAVTESLERELELLCLTGVEDRLQENVRPTLELLRNAG 880
            ::|..:.::...|..|..|:.:|:.|:....|.:|:.|:||..|.:||:||:.|..|:|.|..|.
Human   614 ISESDFQEWRAVYQRASTSVQNRLLKLEESYELIEKNLQLLGATAIEDKLQDQVPETIETLMKAD 678

  Fly   881 VRVWMLTGDKLETACCIAKSSQLIGRNQGLHVL---------RSVK-TRTDAHQEL----NSFRR 931
            :::|:|||||.|||..|..|.:|:.:|.|:.|:         |:|: ||....:..    ::.|:
Human   679 IKIWILTGDKQETAINIGHSCKLLKKNMGMIVINEGSLDVEDRAVEGTRETLSRHCTTLGDALRK 743

  Fly   932 KQGHALVISGESLEVCLQY-YRPEFLELATASPAVVCCRCSPTQKAQVVALIQKHTGKRTCAVGD 995
            :...||:|.|::|:..|.: .|..||:||.:..||:|||.||.||::||.:::|.....|.|:||
Human   744 ENDFALIIDGKTLKYALTFGVRQYFLDLALSCKAVICCRVSPLQKSEVVEMVKKQVKVVTLAIGD 808

  Fly   996 GGNDVSMIQQADAGVGIEGREGRQASLAGDFSIPQFSHIAKLLLIHGRRSYKRSAALSQFVIHRG 1060
            |.|||||||.|..||||.|.||.||:.:.|:||.||.::..||:|||..:|.|.:....:..::.
Human   809 GANDVSMIQTAHVGVGISGNEGLQAANSSDYSIAQFKYLKNLLMIHGAWNYNRVSKCILYCFYKN 873

  Fly  1061 LIITTLQAVFSAVFYLSSVALYQGFLMVGYSTLYTMFPVFSL-VLDQDITSETAVTYPELYKDLS 1124
            :::..::..|:.|...|...|::.:.:..|:.::|..|..:| :.::....|..:.||||||...
Human   874 IVLYIIEIWFAFVNGFSGQILFERWCIGLYNVMFTAMPPLTLGIFERSCRKENMLKYPELYKTSQ 938

  Fly  1125 KGRSLSYKTFFIWVLISIYQGGV--------IMYGALI--------LFVDEFIHIVAISFSALIM 1173
            .....:.|.|::..|..::...:        :.||...        |.:..|:      ::.:::
Human   939 NALDFNTKVFWVHCLNGLFHSVILFWFPLKALQYGTAFGNGKTSDYLLLGNFV------YTFVVI 997

  Fly  1174 TELIMVALTVRTWHRLMVLAELFSLALYLISLAVLHEYFDWEFIWSYDFLW 1224
            |..:...|....|.....:|...|:||:::            |...|..||
Human   998 TVCLKAGLETSYWTWFSHIAIWGSIALWVV------------FFGIYSSLW 1036

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG31729	NP_609634.1	PhoLip_ATPase_N	227..279	CDD:292826	24/51 (47%)
		ATPase-Plipid	228..1252	CDD:273734	314/1079 (29%)
		E1-E2_ATPase	323..525	CDD:278548	63/228 (28%)
		Cation_ATPase	<704..783	CDD:289987	27/78 (35%)
		HAD_like	<975..1019	CDD:304363	24/43 (56%)
		PhoLip_ATPase_C	1021..1249	CDD:292829	45/221 (20%)
ATP8A1	XP_011511917.1	PhoLip_ATPase_N	38..100	CDD:292826	25/61 (41%)
		ATPase-Plipid	49..1093	CDD:273734	314/1079 (29%)
		E1-E2_ATPase	106..>191	CDD:278548	28/87 (32%)
		Cation_ATPase	486..581	CDD:289987	33/101 (33%)
		HAD_like	<803..853	CDD:304363	29/49 (59%)
		PhoLip_ATPase_C	834..1086	CDD:292829	45/221 (20%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165144885
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53737
OrthoDB	1	1.010	-	-		D587717at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.860