DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG31729 and atp9a

DIOPT Version :9

Sequence 1:	NP_609634.1	Gene:	CG31729 / 34736	FlyBaseID:	FBgn0051729	Length:	1256	Species:	Drosophila melanogaster
Sequence 2:	XP_005174184.3	Gene:	atp9a / 101886226	-ID:	-	Length:	1046	Species:	Danio rerio

Alignment Length:	1090	Identity:	656/1090 - (60%)
Similarity:	811/1090 - (74%)	Gaps:	69/1090 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly   181 QHNRRKSKSRSIGNVCKLCLCSCWRKWFRPRELRARTVNLG--RVNTEKFPPNEIRNQKYNFITF 243
            :|.:|....|..|       |..|.:.....:.|.|||.||  ....:::|.|.|.||||||.||
Zfish    11 RHKKRHDNKRRDG-------CCPWSRCCGGGDFRPRTVWLGHPEKREQRYPRNVINNQKYNFFTF 68

  Fly   244 LPLVLFEQFRFFLNLYFLLMALSQFIPDIRIGYPYTYWGPLGFVLMVTICREAVDDLRRHQRDHE 308
            ||.|||.||::|.||||||:|.|||:.::|:|..||||.||||||::||.||||:::|...||.|
Zfish    69 LPGVLFNQFKYFFNLYFLLLACSQFVNELRLGALYTYWVPLGFVLIITIVREAVEEVRCFLRDKE 133

  Fly   309 VNSQKYKRLSSTNISGYEMVPSSKLKVGDVIIVEKNERVPADLILLRTSDRSGSVFVRTDQLDGE 373
            ||||.|.:||:   .|...|.||.::|||:||||||:|||||:|.||||:|:||.|:||||||||
Zfish   134 VNSQIYSKLST---RGTVKVKSSGIQVGDLIIVEKNQRVPADMIFLRTSERNGSCFLRTDQLDGE 195

  Fly   374 TDWKPRLAVPYTQKLSRDSELHSIDASFYVEKPQNDIHSFIATFCMADGSE--DTGLSVENTLWA 436
            ||||.||.|..||:|...::|..|.:..|.|:|..|||:||.||...||..  :..||:||||||
Zfish   196 TDWKLRLPVACTQRLPTAADLLQIRSFVYAEEPNIDIHNFIGTFTREDGDPPVNESLSIENTLWA 260

  Fly   437 NTVVAAGTATGIVIYTGCETRSVMNNSQPRSKVGLLDMEINGLTKVLFCAVLGLSLVMMMLKGFG 501
            :||:|:||..|:|||||.|.|||||.|.||.|:||.|:|:|.|||:||.|::.:||||:.|:.|.
Zfish   261 STVIASGTVVGVVIYTGKELRSVMNTSNPRHKIGLFDLEVNCLTKILFGALVVVSLVMVALQHFA 325

  Fly   502 GPWYRYMFRFVLLFSYIIPISLRVNLDMGKAFYSWQMQNDSNIQGTVVRSTTIPEELGRISYVLT 566
            |.||..:|||:||||.|:||||||||||||..:||.::.||.|.|||||::||||:||||||:||
Zfish   326 GRWYLQIFRFLLLFSNIVPISLRVNLDMGKMVFSWMIKKDSKIPGTVVRASTIPEQLGRISYLLT 390

  Fly   567 DKTGTLTQNEMVFKKIHLGIVSHDADTFHHIGQMIQKLSGNILQQQQGSLSSSSSGGDSTKPMMF 631
            |||||||||||||:::|||.|::..|:...    :|....:...|....|.:|.:.|
Zfish   391 DKTGTLTQNEMVFRRLHLGTVAYGMDSMDE----VQSHVFSAYTQPPQDLQASRAPG-------- 443

  Fly   632 GNRMRRPEGWREWEAVRALALCHNVTPVSDDEDNRSVSTASTVTGGNNSPTKSVINIEAPGST-- 694
            ..::|:....|..|||:|:||.||||||                            .||.|.|
Zfish   444 ATKVRKTISSRVHEAVKAIALVHNVTPV----------------------------YEANGVTDQ 480

  Fly   695 --------DTEHQYQAASPDEIALVKWTEQVGLTLIARDLNTMTLQVKTPSEDNDILLHYQILQL 751
                    ||...|||:||||::||:|||.|||||:.||.::|  |::|||..   :|::.|||:
Zfish   481 AEAEQHYEDTCRVYQASSPDEVSLVQWTESVGLTLVGRDQSSM--QLRTPSGQ---ILNFTILQI 540

  Fly   752 FPFTSESKRMGIIVRESKTGQITFYLKGADVVMSSIVQYNDWLSEESGNMAREGLRTLVVAKKVL 816
            ||||.||||||||||:..||:||||:|||||||:.||||||||.||.|||||||||.||||||.|
Zfish   541 FPFTYESKRMGIIVRDESTGEITFYMKGADVVMAGIVQYNDWLEEECGNMAREGLRVLVVAKKSL 605

  Fly   817 TEEQYSDFETRYNAARLSITDRVAKVAAVTESLERELELLCLTGVEDRLQENVRPTLELLRNAGV 881
            |||||.|||.||..|:||:.||..|||.|.||||.|:||||||||||:||.:||||||:|||||:
Zfish   606 TEEQYQDFEARYVQAKLSVHDRSLKVATVIESLEMEMELLCLTGVEDQLQADVRPTLEILRNAGI 670

  Fly   882 RVWMLTGDKLETACCIAKSSQLIGRNQGLHVLRSVKTRTDAHQELNSFRRKQGHALVISGESLEV 946
            :||||||||||||.|.||::.|:.|||.:||.|.|.||::||.|||:||||...||||||:||||
Zfish   671 KVWMLTGDKLETATCTAKNAHLVTRNQDIHVFRPVTTRSEAHLELNAFRRKHDCALVISGDSLEV 735

  Fly   947 CLQYYRPEFLELATASPAVVCCRCSPTQKAQVVALIQKHTGKRTCAVGDGGNDVSMIQQADAGVG 1011
            ||:||..||:|||...||||||||:||||||:|.|:|:.|||.|||||||||||||||:||.|||
Zfish   736 CLKYYEYEFMELACQCPAVVCCRCAPTQKAQIVRLLQERTGKLTCAVGDGGNDVSMIQEADCGVG 800

  Fly  1012 IEGREGRQASLAGDFSIPQFSHIAKLLLIHGRRSYKRSAALSQFVIHRGLIITTLQAVFSAVFYL 1076
            :||:||:|||||.||||.||.|:.:||::|||.|||||||||||||||.|.|:|:|||||:|||.
Zfish   801 VEGKEGKQASLAADFSITQFKHLGRLLMVHGRNSYKRSAALSQFVIHRSLCISTMQAVFSSVFYF 865

  Fly  1077 SSVALYQGFLMVGYSTLYTMFPVFSLVLDQDITSETAVTYPELYKDLSKGRSLSYKTFFIWVLIS 1141
            :||.||||||::||||:||||||||||||:|:.||.|:.||||||||.|||.||:|||.||||||
Zfish   866 ASVPLYQGFLIIGYSTIYTMFPVFSLVLDKDVKSEVAMLYPELYKDLLKGRPLSFKTFLIWVLIS 930

  Fly  1142 IYQGGVIMYGALILFVDEFIHIVAISFSALIMTELIMVALTVRTWHRLMVLAELFSLALYLISLA 1206
            ||||.:||||||:||..||:|||||||::||:|||:|||||::|||.||::|||.|||.|:.||.
Zfish   931 IYQGSIIMYGALLLFESEFVHIVAISFTSLILTELLMVALTIQTWHWLMIVAELLSLACYIASLV 995

  Fly  1207 VLHEYFDWEFIWSYDFLWKVSLITLVSCLPLYIIKFLRKKCSPPSYLKLS 1256
            .|||:.|..||.:..|:|||:.|||:|||||||:|:||::.|||||.||:
Zfish   996 FLHEFIDVYFIATLSFIWKVTAITLISCLPLYILKYLRRRFSPPSYSKLT 1045

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31729	NP_609634.1	PhoLip_ATPase_N	227..279	CDD:292826	31/51 (61%)
		ATPase-Plipid	228..1252	CDD:273734	640/1035 (62%)
		E1-E2_ATPase	323..525	CDD:278548	120/203 (59%)
		Cation_ATPase	<704..783	CDD:289987	49/78 (63%)
		HAD_like	<975..1019	CDD:304363	33/43 (77%)
		PhoLip_ATPase_C	1021..1249	CDD:292829	159/227 (70%)
atp9a	XP_005174184.3	P-type_ATPase_APLT_Neo1-like	55..966	CDD:319841	593/958 (62%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170578112
Domainoid	1	1.000	349	1.000	Domainoid score	I991
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	1341	1.000	Inparanoid score	I135
OMA	1	1.010	-	-		QHG53737
OrthoDB	1	1.010	-	-		D587717at2759
OrthoFinder	1	1.000	-	-		FOG0002153
OrthoInspector	1	1.000	-	-		otm24471
orthoMCL	1	0.900	-	-		OOG6_101160
Panther	1	1.100	-	-	O	PTHR24092
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1437
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	12	11.910