Protein Alignment CG31729 and ATP9A

DIOPT Version :10

• Sequence 1: NP_609634.1
• Gene: CG31729 / 34736
• FlyBaseID: FBgn0051729
• Length: 1256
• Species: Drosophila melanogaster
• Sequence 2: NP_006036.1
• Gene: ATP9A / 10079
• HGNCID: 13540
• Length: 1047
• Species: Homo sapiens
• Alignment Length: 1087
• Identity: 660/1087 - (60%)
• Similarity: 806/1087 - (74%)
• Gaps: 67/1087 - (6%)

  Fly   184 RRKSKSRSIGNVCKLCLCSCWRKWFRPRELRARTVNLG--RVNTEKFPPNEIRNQKYNFITFLPL 246
            :::..||.....|:      |.:.....|.|.|||.||  ....:::|.|.|.||||||.||||.
Human    13 KKRMDSRPRAGCCE------WLRCCGGGEARPRTVWLGHPEKRDQRYPRNVINNQKYNFFTFLPG 71

  Fly   247 VLFEQFRFFLNLYFLLMALSQFIPDIRIGYPYTYWGPLGFVLMVTICREAVDDLRRHQRDHEVNS 311
            |||.||::|.||||||:|.|||:|::|:|..||||.||||||.||:.||||:::|.:.||.||||
Human    72 VLFNQFKYFFNLYFLLLACSQFVPEMRLGALYTYWVPLGFVLAVTVIREAVEEIRCYVRDKEVNS 136

  Fly   312 QKYKRLSSTNISGYEMVPSSKLKVGDVIIVEKNERVPADLILLRTSDRSGSVFVRTDQLDGETDW 376
            |.|.||::   .|...|.||.::|||:||||||:|||||:|.||||:::||.|:|||||||||||
Human   137 QVYSRLTA---RGTVKVKSSNIQVGDLIIVEKNQRVPADMIFLRTSEKNGSCFLRTDQLDGETDW 198

  Fly   377 KPRLAVPYTQKLSRDSELHSIDASFYVEKPQNDIHSFIATFCMADGSE--DTGLSVENTLWANTV 439
            |.||.|..||:|...::|..|.:..|.|:|..|||:|:.||...|...  ...||:||||||.||
Human   199 KLRLPVACTQRLPTAADLLQIRSYVYAEEPNIDIHNFVGTFTREDSDPPISESLSIENTLWAGTV 263

  Fly   440 VAAGTATGIVIYTGCETRSVMNNSQPRSKVGLLDMEINGLTKVLFCAVLGLSLVMMMLKGFGGPW 504
            ||:||..|:|:|||.|.|||||.|.||||:||.|:|:|.|||:||.|::.:||||:.|:.|.|.|
Human   264 VASGTVVGVVLYTGRELRSVMNTSNPRSKIGLFDLEVNCLTKILFGALVVVSLVMVALQHFAGRW 328

  Fly   505 YRYMFRFVLLFSYIIPISLRVNLDMGKAFYSWQMQNDSNIQGTVVRSTTIPEELGRISYVLTDKT 569
            |..:.||:||||.||||||||||||||..|||.::.||.|.||||||:||||:||||||:|||||
Human   329 YLQIIRFLLLFSNIIPISLRVNLDMGKIVYSWVIRRDSKIPGTVVRSSTIPEQLGRISYLLTDKT 393

  Fly   570 GTLTQNEMVFKKIHLGIVSHDADTFHHIGQMIQKLSGNILQQQQGSLSSSSSGGDSTKPMMFGNR 634
            ||||||||:||::|||.|::..|:...    :|....:|..||       |....:.|......:
Human   394 GTLTQNEMIFKRLHLGTVAYGLDSMDE----VQSHIFSIYTQQ-------SQDPPAQKGPTLTTK 447

  Fly   635 MRRPEGWREWEAVRALALCHNVTPVSDDEDNRSVSTASTVTGGNNSPTKSVINIEAPGSTD---T 696
            :||....|..|||:|:|||||||||                            .|:.|.||   .
Human   448 VRRTMSSRVHEAVKAIALCHNVTPV----------------------------YESNGVTDQAEA 484

  Fly   697 EHQ-------YQAASPDEIALVKWTEQVGLTLIARDLNTMTLQVKTPSEDNDILLHYQILQLFPF 754
            |.|       |||:||||:|||:|||.|||||:.||.::|  |::||   .|.:|::.|||:|||
Human   485 EKQYEDSCRVYQASSPDEVALVQWTESVGLTLVGRDQSSM--QLRTP---GDQILNFTILQIFPF 544

  Fly   755 TSESKRMGIIVRESKTGQITFYLKGADVVMSSIVQYNDWLSEESGNMAREGLRTLVVAKKVLTEE 819
            |.||||||||||:..||:||||:|||||||:.||||||||.||.|||||||||.||||||.|.||
Human   545 TYESKRMGIIVRDESTGEITFYMKGADVVMAGIVQYNDWLEEECGNMAREGLRVLVVAKKSLAEE 609

  Fly   820 QYSDFETRYNAARLSITDRVAKVAAVTESLERELELLCLTGVEDRLQENVRPTLELLRNAGVRVW 884
            ||.|||.||..|:||:.||..|||.|.||||.|:||||||||||:||.:||||||.|||||::||
Human   610 QYQDFEARYVQAKLSVHDRSLKVATVIESLEMEMELLCLTGVEDQLQADVRPTLETLRNAGIKVW 674

  Fly   885 MLTGDKLETACCIAKSSQLIGRNQGLHVLRSVKTRTDAHQELNSFRRKQGHALVISGESLEVCLQ 949
            ||||||||||.|.||::.|:.|||.:||.|.|..|.:||.|||:||||...||||||:||||||:
Human   675 MLTGDKLETATCTAKNAHLVTRNQDIHVFRLVTNRGEAHLELNAFRRKHDCALVISGDSLEVCLK 739

  Fly   950 YYRPEFLELATASPAVVCCRCSPTQKAQVVALIQKHTGKRTCAVGDGGNDVSMIQQADAGVGIEG 1014
            ||..||:|||...||||||||:||||||:|.|:|:.|||.|||||||||||||||::|.|||:||
Human   740 YYEYEFMELACQCPAVVCCRCAPTQKAQIVRLLQERTGKLTCAVGDGGNDVSMIQESDCGVGVEG 804

  Fly  1015 REGRQASLAGDFSIPQFSHIAKLLLIHGRRSYKRSAALSQFVIHRGLIITTLQAVFSAVFYLSSV 1079
            :||:|||||.||||.||.|:.:||::|||.|||||||||||||||.|.|:|:|||||:|||.:||
Human   805 KEGKQASLAADFSITQFKHLGRLLMVHGRNSYKRSAALSQFVIHRSLCISTMQAVFSSVFYFASV 869

  Fly  1080 ALYQGFLMVGYSTLYTMFPVFSLVLDQDITSETAVTYPELYKDLSKGRSLSYKTFFIWVLISIYQ 1144
            .||||||::||||:||||||||||||:|:.||.|:.||||||||.|||.||||||.|||||||||
Human   870 PLYQGFLIIGYSTIYTMFPVFSLVLDKDVKSEVAMLYPELYKDLLKGRPLSYKTFLIWVLISIYQ 934

  Fly  1145 GGVIMYGALILFVDEFIHIVAISFSALIMTELIMVALTVRTWHRLMVLAELFSLALYLISLAVLH 1209
            |..||||||:||..||:|||||||::||:|||:|||||::|||.||.:|||.|||.|:.||..||
Human   935 GSTIMYGALLLFESEFVHIVAISFTSLILTELLMVALTIQTWHWLMTVAELLSLACYIASLVFLH 999

  Fly  1210 EYFDWEFIWSYDFLWKVSLITLVSCLPLYIIKFLRKKCSPPSYLKLS 1256
            |:.|..||.:..||||||:||||||||||::|:||::.|||||.||:
Human  1000 EFIDVYFIATLSFLWKVSVITLVSCLPLYVLKYLRRRFSPPSYSKLT 1046

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG31729	NP_609634.1	P-type_ATPase_APLT_Neo1-like	230..1177	CDD:319841	596/958 (62%)
		Cation_ATPase	<704..781	CDD:463817	48/76 (63%)
ATP9A	NP_006036.1	P-type_ATPase_APLT_Neo1-like	55..967	CDD:319841	596/958 (62%)
		Cation_ATPase	464..571	CDD:463817	66/139 (47%)