DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG31729 and atp10a

DIOPT Version :9

Sequence 1:	NP_609634.1	Gene:	CG31729 / 34736	FlyBaseID:	FBgn0051729	Length:	1256	Species:	Drosophila melanogaster
Sequence 2:	XP_002931688.2	Gene:	atp10a / 100494528	XenbaseID:	XB-GENE-6033735	Length:	1492	Species:	Xenopus tropicalis

Alignment Length:	1309	Identity:	359/1309 - (27%)
Similarity:	566/1309 - (43%)	Gaps:	320/1309 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   184 RRKSKSRSIGNVCKLCLCSCWRKWFRPRELRARTVNLGRVNTEKFPP------NEIRNQKYNFIT 242
            :||.|.|.                 ..||.|.|||....:..|...|      |.|:..||..::
Frog    23 KRKKKKRK-----------------TRRESRVRTVRSNLLLYESDNPNRLYAGNSIKTTKYTALS 70

  Fly   243 FLPLVLFEQFRFFLNLYFLLMALSQFIPDIRIGYPYTYWGPLGFVLMVTICREAVDDLRRHQRDH 307
            |||..|||||....|:||:.|||..|:|.:....|.....|:.|:|.||..::..:|.||::.|.
Frog    71 FLPKNLFEQFHRLANVYFVFMALLNFVPAVNAFKPELALAPVLFILAVTAIKDLWEDYRRYRSDK 135

  Fly   308 EVN----------SQKYKRLSSTNISGYEMVPSSKLKVGDVIIVEKNERVPADLILLRTSDRSGS 362
            |:|          .:||:...           ..:::|||.:.:..||.:|||::||.:||..|.
Frog   136 EINHMDCLVFCRSEKKYREKY-----------WKEVQVGDFVQLRCNEIIPADILLLSSSDPDGL 189

  Fly   363 VFVRTDQLDGETDWKPRLAVPYTQKLSRDSELHSIDASFYVEKPQNDIHSFIATFCMADGSEDTG 427
            ..:.|..|||||:.|.|..|....:|..:.:..:..:....|||.||:..| ..:...:|.: :|
Frog   190 CHIETANLDGETNLKQRQVVKGFVELESEFDPMTFKSIIECEKPNNDLTRF-RGYIHKNGKK-SG 252

  Fly   428 LSVENTLWAN-TVVAAGTATGIVIYTGCETRSVMNNSQPRSKVGLLDMEINGLTKVLFCAVLGLS 491
            |..||.|... |:......:|||||.|.||::::||:.||.|...|:.::|   |.:|..|| :.
Frog   253 LFKENLLLRGCTIRNTEVVSGIVIYAGHETKALLNNNGPRYKRSKLERQMN---KDVFWCVL-IL 313

  Fly   492 LVMMMLKGFG-GPW-YRY--------------------------MFRFVLLFSYIIPISLRVNLD 528
            |:|.:....| ..| ::|                          .|..:::...:||:||.|:::
Frog   314 LIMCLFSAVGHALWVWQYGEKRPVFDVLGSDGKYVKPFLSAVYLFFTMIIVLQVLIPVSLYVSIE 378

  Fly   529 MGK---AFYSWQ------MQNDSNIQGTVVRSTTIPEELGRISYVLTDKTGTLTQNEMVFKKIHL 584
            :.|   .::..|      .:.||.:|   .|:..|.|:||:|.||.:|||||||:|:|||::..:
Frog   379 IVKICQVYFIHQDKDLYDEETDSQLQ---CRALNITEDLGQIQYVFSDKTGTLTENKMVFRRCTV 440

  Fly   585 GIV--SHD-----------ADT-------------------FHHIGQMIQKLSGNILQQQQGSLS 617
            ..|  |||           ||:                   .||..:...:.......::.||.:
Frog   441 SGVEYSHDDNAKRLAMYQEADSEDEVNGPKTGTLPRRDSSGSHHSVKAAHRSQSTKTHRRTGSRA 505

  Fly   618 SSSSGGDSTKPMMFGNRMRR--------PEGWRE-------------------------WEAVRA 649
            .:......:|...|.:.|.:        .|...|                         ::...|
Frog   506 EAMKANILSKHTAFSSPMEKDITPDPKLQEKVNECAKTLKIMRNHKQPFSQLTAELSDIFDFFTA 570

  Fly   650 LALCHNV-------------------TPVSDDEDNRSVSTASTVTGGNNSPTKSVI--------- 686
            |.:|:.|                   :||...||.....|.|.:|.|:||.:.|.:
Frog   571 LTICNTVVVTSPNQPRQKVRVRFELKSPVKTIEDFIRRFTPSRLTSGSNSSSSSSLGTNKSMHRA 635

  Fly   687 --------NIEA-----------------------PG------STDTEHQYQAASPDEIALVKWT 714
                    :||.                       ||      ..:.:.:::|.||||.|||..:
Frog   636 GSSIMSSSSIEGSFTKLERKLSSSPQINFTGLGTQPGFKEQVDGHEGDLRFEAESPDEAALVYAS 700

  Fly   715 EQVGLTLIARDLNTMTLQVKTPSEDNDILLHYQILQLFPFTSESKRMGIIVRESKTGQITFYLKG 779
            ......|:.|..:.:|:::.....     |::::|....|.|..|||.::||...|.:|..|.||
Frog   701 RAYNCALVGRLSDQVTVELPHLGR-----LNFELLHTLGFDSVRKRMSVVVRHPLTDEIVVYAKG 760

  Fly   780 ADVVMSSIVQ---YNDWLSEESGNM-----------AREGLRTLVVAKKVLTEEQYSDFETRYNA 830
            ||.|:..::|   .:|.|.:....:           |.:|||||.:||:||::|:|:.:...:..
Frog   761 ADSVILDLIQPCSKDDRLGKHQRKIQAKTQKYLNCYAVDGLRTLCIAKRVLSKEEYACWLKFHLQ 825

  Fly   831 ARLSITDRVAKVAAVTESLERELELLCLTGVEDRLQENVRPTLELLRNAGVRVWMLTGDKLETAC 895
            |..|:.:|...:......||..|.||..||:||||||.|..|:..||.||:::|:|||||.|||.
Frog   826 AESSLDNREELLFQSAVRLETNLHLLGATGIEDRLQEGVPETITRLRKAGIQIWVLTGDKQETAV 890

  Fly   896 CIAKSSQLIGR-------------------NQGLHVLRSV-----------KTRTDA--HQELNS 928
            .|..|.:|:..                   .|.||.::|.           .|..|:  |..|..
Frog   891 NIGYSCKLLDHEDDLITLNAESLEECSTLLEQCLHYIQSKFSSGLQEKVVGGTGIDSVQHNTLWP 955

  Fly   929 FRRKQGH-ALVISGESLEVCLQYYRPE-FLELATASPAVVCCRCSPTQKAQVVALIQKHTGKRTC 991
            ...||.. .|||.|::|...|...:.: ||.||....:|:|||.:|.||:.||.|::......|.
Frog   956 PNLKQSSLGLVIDGKTLAFALDITQSDKFLLLARKCRSVLCCRSTPLQKSLVVKLVRDKLRAMTL 1020

  Fly   992 AVGDGGNDVSMIQQADAGVGIEGREGRQASLAGDFSIPQFSHIAKLLLIHGRRSYKRSAALSQFV 1056
            |||||.|||||||.||.||||.|:||.||.:|.||::|:|.|:.||||:|||..|.|.|.:..:.
Frog  1021 AVGDGTNDVSMIQVADVGVGISGQEGMQAVMASDFAVPRFRHLEKLLLVHGRWCYSRLANMVLYF 1085

  Fly  1057 IHRGLIITTLQAVFSAVFY--LSSVALYQGFLMVGYSTLYTMFP-VFSLVLDQDITSETAVTYPE 1118
            .::..:...|  :|...||  .|..|:...:.::.::.|::..| :.:.:||:|:.:|.....||
Frog  1086 FYKNAMFVAL--LFWYQFYCGFSGSAMIDQWYLIFFNLLFSSIPQLITGILDKDLPAELLTANPE 1148

  Fly  1119 LYKDLSKGRSL-SYKTFFIW--VLISIYQGGVIMYGALILFVDEFIHIVAIS---FSALIMTELI 1177
            |||   .|.:: .||....|  ::.:.||..|..:.....|.|..|.:....   .:..::|.::
Frog  1149 LYK---SGPNMEEYKPHMFWLNMIDAFYQSLVCFFIPYFSFFDSDIDLFTWGTPIVTCALLTIMM 1210

  Fly  1178 MVALTVRTWHRLMVLAELFSLALYLISLAVLHEYFDWEFIWSYDFLWKVSLITLVSCLPLYIIKF 1242
            .:.:..:||..:.|.:.:||:.|:                      :.|:|:...||
Frog  1211 HLGMETKTWTWINVSSIVFSILLF----------------------FTVALVYNSSC-------- 1245

  Fly  1243 LRKKCSPPS 1251
              ..|:|||
Frog  1246 --PTCNPPS 1252

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31729	NP_609634.1	PhoLip_ATPase_N	227..279	CDD:292826	22/57 (39%)
		ATPase-Plipid	228..1252	CDD:273734	348/1265 (28%)
		E1-E2_ATPase	323..525	CDD:278548	65/230 (28%)
		Cation_ATPase	<704..783	CDD:289987	26/78 (33%)
		HAD_like	<975..1019	CDD:304363	26/43 (60%)
		PhoLip_ATPase_C	1021..1249	CDD:292829	55/236 (23%)
atp10a	XP_002931688.2	P-type_ATPase_APLT_Dnf-like	58..1182	CDD:319770	329/1153 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D587717at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010