DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Uvrag and Uvrag

DIOPT Version :9

Sequence 1:	NP_609632.1	Gene:	Uvrag / 34735	FlyBaseID:	FBgn0032499	Length:	696	Species:	Drosophila melanogaster
Sequence 2:	NP_848750.3	Gene:	Uvrag / 78610	MGIID:	1925860	Length:	698	Species:	Mus musculus

Alignment Length:	722	Identity:	168/722 - (23%)
Similarity:	270/722 - (37%)	Gaps:	223/722 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 LATQQLRLRNLNRIQGFNIESWPHEKSLELDDPDDVLLYYTLH---TDKASEAFYTSEKLPQRHQ 74
            |.:||.|||:|..|...||.:....:.|:        .|:|||   .:|..:.||.||.:..
Mouse    35 LPSQQRRLRHLRNIAARNIVNRNGHQLLD--------TYFTLHLCDNEKIFKEFYRSEVIKN--- 88

  Fly    75 QQKWAEICTDDEAWRK-----------TNAQCVCVKVWKHYSAERRDGQPPEVEQRHKDVFGRSQ 128
                    :.:..||.           |:..|..||:|         |...|..|
Mouse    89 --------SLNPTWRSLDFGIMPDRLDTSVSCFVVKIW---------GGKEEAFQ---------- 126

  Fly   129 LTPSRLPRPPELLFSWGVYFSGLIPLSPLTLSQCGRNCLVFQLNGEQFASPSMISEQALQSQLHL 193
                       ||..|.||..||..|.. .:....:|.::|.||...:.:|       .:.:.|.
Mouse   127 -----------LLIEWKVYLDGLKYLGQ-QIHARNQNEIIFGLNDGYYGAP-------CEHKGHP 172

  Fly   194 HYQKYAEEEKLEEPQDEGINSPAVSRSSSPVLRMSTMRYAQLKCQRQEIRRSNNLEKLLTLQRLQ 258
            :.||    ..|:..|:       ..|:|..|..:..:..||...::.::          |:|||.
Mouse   173 NAQK----NLLQVDQN-------CVRNSYDVFSLLRLHRAQCAIKQTQV----------TVQRLG 216

  Fly   259 RLHQQKRRQMAEVCREIARLSVHC------VTRNELRLKPRTTSLSGDYSAHQYHSMGRALSVLL 317
            :..::|.| :.....|:.:.| .|      |.||||.              .|..::||.::.|
Mouse   217 KEIEEKLR-LTSTSNELKKES-ECLRLKILVLRNELE--------------RQKKALGREVAFL- 264

  Fly   318 AEQQQIAPLTLYNAQQLTRRIEALSSQQRLLKAERETFRQRNERTRQLLKEMREQREAQQWELHS 382
             .:||:|         |..:..|.|::...|:.::::           |.|:|::..|
Mouse   265 -HKQQMA---------LQDKGSAFSTEHGKLQLQKDS-----------LSELRKECTA------- 301

  Fly   383 QRHRLEKERLELRTLAPQHLEQRDQKRQIERQVERRMSTLVLELQEIYNIQNVGGRQFSICGIAF 447
                  |..|.|:|.|               |:..|...|:.||..||.|.....:.:.:||:..
Mouse   302 ------KRELFLKTNA---------------QLTIRCRQLLSELSYIYPIDLNENKDYFVCGVKL 345

  Fly   448 PHMEQYTSESRQAANAQLLDNVSPLAVSAALGYVAHLVQMLAIIMDRPLRNRILYEPSKARIVDD 512
            |:.|.:          |..|:.|   ::.||||.||||.|::..:..|||..|:::.|::.|.|:
Mouse   346 PNSEDF----------QAKDDGS---IAVALGYTAHLVSMISFFLQVPLRYPIIHKGSRSTIKDN 397

  Fly   513 IKE-LTYTTREFPLYTRSILPSQQTKYAIYLLRQNVSQLCFDI-TGQCDLRNTFGNLLELFSTLR 575
            |.: ||...||||||.:. ....|..|.:|||.:|::||.:.. .|..|||.|..||      ..
Mouse   398 INDKLTEKEREFPLYPKG-GEKLQFDYGVYLLNKNIAQLRYQHGLGTPDLRQTLPNL------KN 455

  Fly   576 YIERTQRDEVDERDGTAVGAGCGEARLANGLTAP-HLSQSHSSVDMNH---VPLPTGV-----NA 631
            ::|.          |..|  .|....::|.:..| ..|.:....|...   :|.|..|     ::
Mouse   456 FMEH----------GLMV--RCDRHHISNAIPVPKRQSSTFGGADGGFSAGIPSPDKVHRKRASS 508

  Fly   632 VKDALLQQLLPPGVSEALAIEGYA-----STQRICRSVGSYSDGEDEFRPR-----------LEH 680
            ..:.|..:..||..:.||...|.|     .::|....:.|..|...:|...           :..
Mouse   509 ENERLQYKTPPPSYNSALTQPGVAMPTSGDSERKVAPLSSSLDTSLDFSKENKKAGVDLGSSVSG 573

  Fly   681 NYSNSDS 687
            ::.||||
Mouse   574 DHGNSDS 580

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Uvrag	NP_609632.1	Atg14	329..574	CDD:287195	68/246 (28%)
Uvrag	NP_848750.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..21
		C2	44..>118	CDD:175973	17/87 (20%)
		Atg14	183..441	CDD:370867	50/263 (19%)
		Sufficient for interaction with STX7, VTI1B AND STX8. /evidence=ECO:0000250\|UniProtKB:Q9P2Y5	199..268		11/68 (16%)
		Sufficient for interaction with VPS16, required for interaction with CEP63. /evidence=ECO:0000250\|UniProtKB:Q9P2Y5	269..441		35/177 (20%)
		Required for interaction with PRKDC, XRCC6 and XRCC5. /evidence=ECO:0000250\|UniProtKB:Q9P2Y5	442..698		75/271 (28%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	477..551		28/74 (38%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	565..586		8/21 (38%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167835243
Domainoid	1	1.000	87	1.000	Domainoid score	I8046
eggNOG	1	0.900	-	-		E1_KOG2896
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0005474
OrthoInspector	1	1.000	-	-		oto95029
orthoMCL	1	0.900	-	-		OOG6_104014
Panther	1	1.100	-	-	LDO	PTHR15157
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X5873
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	11	10.700