DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Uvrag and UVRAG

DIOPT Version :9

Sequence 1:	NP_609632.1	Gene:	Uvrag / 34735	FlyBaseID:	FBgn0032499	Length:	696	Species:	Drosophila melanogaster
Sequence 2:	NP_001373600.1	Gene:	UVRAG / 7405	HGNCID:	12640	Length:	725	Species:	Homo sapiens

Alignment Length:	711	Identity:	163/711 - (22%)
Similarity:	263/711 - (36%)	Gaps:	211/711 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 LATQQLRLRNLNRIQGFNIESWPHEKSLELDDPDDVLLYYTLH---TDKASEAFYTSEKLPQRHQ 74
            |.:||.|||:|..|...||.:....:.|:        .|:|||   |:|..:.||.||.:..
Human    35 LPSQQRRLRHLRNIAARNIVNRNGHQLLD--------TYFTLHLCSTEKIYKEFYRSEVIKN--- 88

  Fly    75 QQKWAEICTDDEAWRK-----------TNAQCVCVKVWKHYSAERRDGQPPEVEQRHKDVFGRSQ 128
                    :.:..||.           |:..|..||:|.                      |:..
Human    89 --------SLNPTWRSLDFGIMPDRLDTSVSCFVVKIWG----------------------GKEN 123

  Fly   129 LTPSRLPRPPELLFSWGVYFSGLIPLSPLTLSQCGRNCLVFQLNGEQFASPSMISEQALQSQLHL 193
            :.        :||..|.|...||..|.. .:....:|.::|.||...:.:|             .
Human   124 IY--------QLLIEWKVCLDGLKYLGQ-QIHARNQNEIIFGLNDGYYGAP-------------F 166

  Fly   194 HYQKYAEEEKLEEPQDEGINSPAVSRSSSPVLRMSTMRYAQLKCQRQEIRRSNNLEKLLTLQRLQ 258
            .::.|:..:|                   .:|         |:..:..:|.|.::..||.|.|.|
Human   167 EHKGYSNAQK-------------------TIL---------LQVDQNCVRNSYDVFSLLRLHRAQ 203

  Fly   259 RLHQQKRRQMAEVCREIARLSVHCVTRNELRLKPRTTSLS----GDYSAHQYHSMGRALSVLLAE 319
            ...:|.:..:.::.:||........|.|||:.|.....|.    .:....|..::||  .|.|..
Human   204 CAIKQTQVTVQKIGKEIEEKLRLTSTSNELKKKSECLQLKILVLQNELERQKKALGR--EVALLH 266

  Fly   320 QQQIAPLTLYNAQQLTRRIEALSSQQRLLKAERETFRQRNERTRQLLKEMREQREAQQWELHSQR 384
            :||||         |..:..|.|::...|:.::|:           |.|:|::..|
Human   267 KQQIA---------LQDKGSAFSAEHLKLQLQKES-----------LNELRKECTA--------- 302

  Fly   385 HRLEKERLELRTLAPQHLEQRDQKRQIERQVERRMSTLVLELQEIYNIQNVGGRQFSICGIAFPH 449
                |..|.|:|.|               |:..|...|:.||..||.|.....:.:.:||:..|:
Human   303 ----KRELFLKTNA---------------QLTIRCRQLLSELSYIYPIDLNEHKDYFVCGVKLPN 348

  Fly   450 MEQYTSESRQAANAQLLDNVSPLAVSAALGYVAHLVQMLAIIMDRPLRNRILYEPSKARIVDDIK 514
            .|.:          |..|:.|   ::.||||.||||.|::..:..|||..|:::.|::.|.|:|.
Human   349 SEDF----------QAKDDGS---IAVALGYTAHLVSMISFFLQVPLRYPIIHKGSRSTIKDNIN 400

  Fly   515 E-LTYTTREFPLYTRSILPSQQTKYAIYLLRQNVSQLCFDI-TGQCDLRNTFGNL---LELFSTL 574
            : ||...||||||.:. ....|..|.:|||.:|::||.:.. .|..|||.|..||   :|....:
Human   401 DKLTEKEREFPLYPKG-GEKLQFDYGVYLLNKNIAQLRYQHGLGTPDLRQTLPNLKNFMEHGLMV 464

  Fly   575 RYIE------------RTQRDEVDERDGTAVGAGCGEARLANGLTAPHLSQS-HSSVDMNH---V 623
            |.|:            ..:|..:       .|.||.....::.:..|....| ....|:..   :
Human   465 RCIKPQMSCFQFGAKPSWKRQPL-------TGNGCDRHHTSSAIPVPKRQSSIFGGADVGFSGGI 522

  Fly   624 PLP-----TGVNAVKDALLQQLLPPGVSEALA-----IEGYASTQRICRSVGSYSDGEDEF 674
            |.|     ...::..:.|..:..||..:.|||     :.....|:|...|:.|..|...:|
Human   523 PSPDKGHRKRASSENERLQYKTPPPSYNSALAQPVTTVPSMGETERKITSLSSSLDTSLDF 583

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Uvrag	NP_609632.1	Atg14	329..574	CDD:287195	70/249 (28%)
UVRAG	NP_001373600.1	C2	44..>118	CDD:175973	21/92 (23%)
UVRAG	NP_001373600.1	Atg14	184..442	CDD:370867	87/321 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165145142
Domainoid	1	1.000	87	1.000	Domainoid score	I8021
eggNOG	1	0.900	-	-		E1_KOG2896
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	92	1.000	Inparanoid score	I5092
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1081121at2759
OrthoFinder	1	1.000	-	-		FOG0005474
OrthoInspector	1	1.000	-	-		oto91446
orthoMCL	1	0.900	-	-		OOG6_104014
Panther	1	1.100	-	-	LDO	PTHR15157
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R105
SonicParanoid	1	1.000	-	-		X5873
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	13	12.790