Protein Alignment Drep4 and DFFB

DIOPT Version :9

• Sequence 1: NP_609631.1
• Gene: Drep4 / 34734
• FlyBaseID: FBgn0028406
• Length: 450
• Species: Drosophila melanogaster
• Sequence 2: NP_001269598.1
• Gene: DFFB / 1677
• HGNCID: 2773
• Length: 362
• Species: Homo sapiens
• Alignment Length: 423
• Identity: 108/423 - (25%)
• Similarity: 171/423 - (40%)
• Gaps: 138/423 - (32%)

  Fly    59 RKYGIGANSLEMLIAKAKSKFPLLE--PHLYLASDGFEVSDDEYLKSLP--AQTLFIVSGPDAVI 119
            ||:|:...|.:.::.|...:|.|.|  ..|.|..||.|:::| |..|:|  |:.:.:..|
Human    17 RKFGVAGRSCQEVLRKGCLRFQLPERGSRLCLYEDGTELTED-YFPSVPDNAELVLLTLG----- 75

  Fly   120 TTDADFEFEKMRQQSPLLK--------VADI---------FYD-------------FIEQHPEKF 154
            ......|::.:.:...||.        |||:         |::             ..||.|::
Human    76 QAWQGCEWQGLWRMCLLLDRHLLFVPLVADVSDIRRFLSAFHEPQVGLIQAAQQLLCDEQAPQR- 139

  Fly   155 RRMITEYEHQKQRRVLDNSKTHLSLKAEHVEWFTGGEERFHSKEEAMATRAQTRVRGYY------ 213
            :|::.:..|...:.:...:      :||...||.|.|.||.||...:....::|:|.|.
Human   140 QRLLADLLHNVSQNIAAET------RAEDPPWFEGLESRFQSKSGYLRYSCESRIRSYLREVSSY 198

  Fly   214 -----YKAKEELTRNPLYRQNAKARQVINSVLEKFRYLLIGCDFFSMMFDRNCKQKHEFLKQHLG 273
                 .:|:||..|            |:.|:.::.|.:    .:....|||..|
Human   199 PSTVGAEAQEEFLR------------VLGSMCQRLRSM----QYNGSYFDRGAK----------- 236

  Fly   274 DEETDAGRIPSKRLRQVIREYTKENCILDEWSTSLCSDLGDFYCQGSYSENGNSCSKQHTINPYA 338
                                          ..:.||:..|.|.|||.:  :.:||..:|:||||:
Human   237 ------------------------------GGSRLCTPEGWFSCQGPF--DMDSCLSRHSINPYS 269

  Fly   339 SRENLILFQVWNLDHQIELCRTILPALVANVEELVSHPQTKCSIHKKQVVDISVLEYFLE-IFSL 402
            :||:.|||..|||||.||..|||:|.||..::|           ...:.||   .|||.. :|:.
Human   270 NRESRILFSTWNLDHIIEKKRTIIPTLVEAIKE-----------QDGREVD---WEYFYGLLFTS 320

  Fly   403 KNLKLVHIVCHEKAQRSNRSNGRLLCSDCHEYR 435
            :||||||||||:|      :..:|.|.....|:
Human   321 ENLKLVHIVCHKK------TTHKLNCDPSRIYK 347

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Drep4	NP_609631.1	CIDE_N	46..121	CDD:119367	19/65 (29%)
		DFF40	151..435	CDD:286333	79/295 (27%)
DFFB	NP_001269598.1	CIDE_N_CAD	4..80	CDD:119368	19/68 (28%)
		DFF40	124..347	CDD:286333	81/308 (26%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165143589
Domainoid	1	1.000	92	1.000	Domainoid score	I7634
eggNOG	1	0.900	-	-		E1_28U0V
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H3241
Inparanoid	1	1.050	105	1.000	Inparanoid score	I4950
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG49709
OrthoDB	1	1.010	-	-		D1254881at2759
OrthoFinder	1	1.000	-	-		FOG0007418
OrthoInspector	1	1.000	-	-		oto90769
orthoMCL	1	0.900	-	-		OOG6_109655
Panther	1	1.100	-	-	LDO	PTHR13067
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5293
SonicParanoid	1	1.000	-	-		X5550
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	16	15.800