DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Drep4 and dffb

DIOPT Version :9

Sequence 1:	NP_609631.1	Gene:	Drep4 / 34734	FlyBaseID:	FBgn0028406	Length:	450	Species:	Drosophila melanogaster
Sequence 2:	NP_001120636.1	Gene:	dffb / 100145806	XenbaseID:	XB-GENE-990152	Length:	340	Species:	Xenopus tropicalis

Alignment Length:	416	Identity:	110/416 - (26%)
Similarity:	185/416 - (44%)	Gaps:	106/416 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    35 SSSESRGTAGAPMRGYKVTDNERTRKYGIGANSLEMLIAKAKSKFPLLEPH--LYLASDGFEVSD 97
            :|:|.:      :|.||:......:||||...:|..|..||..||.|..|.  :.|..||.|||
Frog     6 TSTEKK------IRCYKIRTLHSQQKYGIACKNLAELKQKACRKFQLDCPTTCVCLYEDGTEVS- 63

  Fly    98 DEYLKSLPAQTLFIVSGP----DAVITTDADFEFEKMRQQSPLLKVA-DIFYDFIEQHPEKFRRM 157
            :|||:::|..|:.::..|    ...::....|......:|:.:::.| .:..|  |..|::.:.:
Frog    64 EEYLETVPDNTVLLLLTPGQTWQGYVSDIERFLNAFYARQTCIVEAAHKLLAD--EDAPKRQKLL 126

  Fly   158 ITEYEHQKQRRVLDNSKTHLSLKAEHVEWFTGGEERFHSKEEAMATRAQTRVRGYYYKAK----- 217
            :....:..:..:.:|.|       :...||.|.|.||.:|...|....::|||.|..:.:
Frog   127 VDFISNLNENILAENRK-------DDESWFEGIESRFKNKSSYMRYSCESRVRSYMKEVQSHTDS 184

  Fly   218 -EELTRNPLYRQNAKARQVINSVLEKFRYLLI-GCDFFSMMFDRNCKQKHEFLKQHLGDEETDAG 280
             |.:||:       :.:::|:::.::.|.:.. ||     .|||. :||
Frog   185 VEPVTRD-------EYKRIIDAMYDELRAVKYNGC-----YFDRT-EQK---------------- 220

  Fly   281 RIPSKRLRQVIREYTKENCILDEWSTSLCSDLGDFYCQGSYSENGNSCSKQHTINPYASRENLIL 345
                                    ...||:..|.|.|||.:  :.::||.:|:||||::||..||
Frog   221 ------------------------LNRLCTSEGWFSCQGPF--DADACSSRHSINPYSNRECRIL 259

  Fly   346 FQVWNLDHQIELCRTILPALVANVEELVSHPQTKCSIHKKQVVDISVLEYFLEIFSLKNLKLVHI 410
            |..|||||:||..|||:|.||..::|             :...:::...:|..:|:.:||.||||
Frog   260 FSTWNLDHKIEKKRTIIPCLVKALKE-------------RNEREVNWQYFFSLLFTKENLNLVHI 311

  Fly   411 VCHEKAQRSNRSNGRLLCSDCHE-YR 435
            .||:|...:       |..||.: ||
Frog   312 ACHKKTSHN-------LSLDCSQIYR 330

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Drep4	NP_609631.1	CIDE_N	46..121	CDD:119367	27/80 (34%)
Drep4	NP_609631.1	DFF40	151..435	CDD:286333	74/291 (25%)
dffb	NP_001120636.1	CIDE_N_CAD	11..87	CDD:119368	27/82 (33%)
dffb	NP_001120636.1	DFF40	107..330	CDD:286333	77/306 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	90	1.000	Domainoid score	I7681
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H3241
Inparanoid	1	1.050	113	1.000	Inparanoid score	I4712
OMA	1	1.010	-	-		QHG49709
OrthoDB	1	1.010	-	-		D1254881at2759
OrthoFinder	1	1.000	-	-		FOG0007418
OrthoInspector	1	1.000	-	-		oto104564
Panther	1	1.100	-	-	LDO	PTHR13067
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5293
SonicParanoid	1	1.000	-	-		X5550
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	12	12.110