Protein Alignment l(2)k05911 and LPA

DIOPT Version :10

• Sequence 1: NP_723797.3
• Gene: l(2)k05911 / 34731
• FlyBaseID: FBgn0284244
• Length: 639
• Species: Drosophila melanogaster
• Sequence 2: NP_005568.2
• Gene: LPA / 4018
• HGNCID: 6667
• Length: 2040
• Species: Homo sapiens
• Alignment Length: 712
• Identity: 174/712 - (24%)
• Similarity: 246/712 - (34%)
• Gaps: 233/712 - (32%)

  Fly   105 PGEGSKCLTSRGQPGVCVRIDGCRQYYR--LARQISIFTLRQW---------------PQANGLG 152
            |.|.:....|.|... |.|.||  |.||  |:..|:..|.:.|               |.|   |
Human  1373 PSEEAPTENSTGVQD-CYRGDG--QSYRGTLSTTITGRTCQSWSSMTPHWHRRIPLYYPNA---G 1431

  Fly   153 LNGNMCNFFDMLGRVNNGICCTDIDAN----SFGVFPLPGTTTTTTTTTEMPSVVADEEDREHVI 213
            |..|.|...|...|.    .|..:|.:    ...:...|.|.::..||..:..|.:.|...|...
Human  1432 LTRNYCRNPDAEIRP----WCYTMDPSVRWEYCNLTRCPVTESSVLTTPTVAPVPSTEAPSEQAP 1492

  Fly   214 PEGE--VEGVYPPD-----------------------VP----RPEEPIDNANSVED---TPD-- 244
            ||..  |:..|..|                       :|    |..|...||...|:   .||
Human  1493 PEKSPVVQDCYHGDGRSYRGISSTTVTGRTCQSWSSMIPHWHQRTPENYPNAGLTENYCRNPDSG 1557

  Fly   245 ---------------FQDINTIEGNPPGADKKPEAEPV--------GEPVEQ-PISTQPASTIH- 284
                           :.::........|..:.|...||        ..|.|| |:..|   ..|
Human  1558 KQPWCYTTDPCVRWEYCNLTQCSETESGVLETPTVVPVPSMEAHSEAAPTEQTPVVRQ---CYHG 1619

  Fly   285 ---PYQWPFGSFAGGQ----WPPALP-THPPTTGGWP-----------PPLPTHP------PNHH 324
               .|:..|.:...|:    |....| .|..|...:|           |...|.|      |:..
Human  1620 NGQSYRGTFSTTVTGRTCQSWSSMTPHRHQRTPENYPNDGLTMNYCRNPDADTGPWCFTMDPSIR 1684

  Fly   325 YP---------------THPTTGGVPST------------------KRTTPRPTSPARPTTTRRP 356
            :.               ..||...|||.                  |:.|....:|.:....:.|
Human  1685 WEYCNLTRCSDTEGTVVAPPTVIQVPSLGPPSEQDCMFGNGKGYRGKKATTVTGTPCQEWAAQEP 1749

  Fly   357 ------------------TYPSYP-----SPVTTTTTTRR-------PVSGTSSEGLPLQCGNKN 391
                              .|...|     .|...|...|:       |:..:||    ..|| |.
Human  1750 HRHSTFIPGTNKWAGLEKNYCRNPDGDINGPWCYTMNPRKLFDYCDIPLCASSS----FDCG-KP 1809

  Fly   392 PVTPDQ--ERIVGGINASPHEFPW-IAVLFKSGKQFCGGSLITNSHILTAAHCV---ARMTSWDV 450
            .|.|.:  ..||||..|.||.:|| :::..:.||.||||:||:...:||||||:   :|.:|:.|
Human  1810 QVEPKKCPGSIVGGCVAHPHSWPWQVSLRTRFGKHFCGGTLISPEWVLTAAHCLKKSSRPSSYKV 1874

  Fly   451 AALTAHLGDYNIGTDFEVQHVSRRIKRLVRHKGFEFSTLHNDVAILTLSEPVPFTREIQPICLPT 515
             .|.||   ..:..:..||.:  .:.||.      ......|:|:|.||.|...|.::.|.|||
Human  1875 -ILGAH---QEVNLESHVQEI--EVSRLF------LEPTQADIALLKLSRPAVITDKVMPACLP- 1926

  Fly   516 SP----SQQSRSYSGQVATVAGWGSLREN-GPQPSILQKVDIPIWTNAECAR-KYGRAAPGGIIE 574
            ||    :.::..|      :.|||..:.. |  ..:|::..:.:..|..|.. ||
Human  1927 SPDYMVTARTECY------ITGWGETQGTFG--TGLLKEAQLLVIENEVCNHYKY---------- 1973

  Fly   575 SMICAGQAAK--DSCSGDSGGPMVINDGGRYTQVGIVSWGIGCGKGQYPGVYTRVTSLLPWI 634
              |||...|:  |||.||||||:|..:..:|...|:.|||:||.:...||||.||:..:.||
Human  1974 --ICAEHLARGTDSCQGDSGGPLVCFEKDKYILQGVTSWGLGCARPNKPGVYARVSRFVTWI 2033

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
l(2)k05911	NP_723797.3	CLIP	111..174	CDD:197829	21/79 (27%)
		PTZ00449	<198..>376	CDD:185628	53/324 (16%)
		Tryp_SPc	400..637	CDD:238113	85/247 (34%)
LPA	NP_005568.2	Kringle	28..105	CDD:395005
		Kringle	142..219	CDD:395005
		Kringle	256..333	CDD:395005
		Kringle	370..447	CDD:395005
		Kringle	484..561	CDD:395005
		Kringle	598..675	CDD:395005
		Kringle	712..789	CDD:395005
		Kringle	826..903	CDD:395005
		KR	938..1019	CDD:214527
		Kringle	1054..1131	CDD:395005
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1147..1166
		KR	1166..1246	CDD:214527
		KR	1272..1352	CDD:214527
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1365..1388		4/15 (27%)
		KR	1386..1466	CDD:214527	21/89 (24%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1476..1497		5/20 (25%)
		KR	1500..1581	CDD:214527	10/80 (13%)
		KR	1614..1695	CDD:214527	14/83 (17%)
		Kringle	1720..1799	CDD:395005	10/78 (13%)
		Tryp_SPc	1820..2034	CDD:238113	85/247 (34%)