Protein Alignment l(2)k05911 and TMPRSS12

DIOPT Version :10

• Sequence 1: NP_723797.3
• Gene: l(2)k05911 / 34731
• FlyBaseID: FBgn0284244
• Length: 639
• Species: Drosophila melanogaster
• Sequence 2: NP_872365.2
• Gene: TMPRSS12 / 283471
• HGNCID: 28779
• Length: 348
• Species: Homo sapiens
• Alignment Length: 331
• Identity: 100/331 - (30%)
• Similarity: 147/331 - (44%)
• Gaps: 51/331 - (15%)

  Fly   322 NHHYPTHPTTGGVPSTKRTTPRPTSPARPTTTRRPTYPSYPSPVTTTTTTRRPVSGTSSEGLPLQ 386
            :|.|..|.:..|   ..|..|.|          .|...|..:........||...|..:|    .
Human    16 SHLYSDHYSPSG---RHRLGPSP----------EPAASSQQAEAVRKRLRRRREGGAHAE----D 63

  Fly   387 CGNKNPVTP--DQERIVGGINASPHEFPWIAVL-FKSGK---QFCGGSLITNSHILTAAHCVARM 445
            ||.. |:..  ...||:||..|....:||:..| .|.|:   ..|||:|:....:||||||....
Human    64 CGTA-PLKDVLQGSRIIGGTEAQAGAWPWVVSLQIKYGRVLVHVCGGTLVRERWVLTAAHCTKDA 127

  Fly   446 TSWDVAALTAHLGDYNIGTDFEVQHVSR-RIKRLVRHKGFEFSTLHNDVAILTLSEPVPFTREIQ 509
            :  |....||.:|..||...:  .|..: :||.::.|..|...:..||:|:..|.:.|.:...||
Human   128 S--DPLMWTAVIGTNNIHGRY--PHTKKIKIKAIIIHPNFILESYVNDIALFHLKKAVRYNDYIQ 188

  Fly   510 PICLPTSPSQ----QSRSYSGQVATVAGWGSLRENGPQPSILQKVDIPIWTNAEC--ARKYGRAA 568
            |||||....|    .::.:      ::|||..:|.|...:|||..::...:...|  .|.|
Human   189 PICLPFDVFQILDGNTKCF------ISGWGRTKEEGNATNILQDAEVHYISREMCNSERSY---- 243

  Fly   569 PGGII-ESMICAG--QAAKDSCSGDSGGPMV--INDGGRYTQVGIVSWGIGCGKGQYPGVYTRVT 628
             |||| .:..|||  ..|.|:|.||||||::  :.:..|:..:||.|:|.|||:..:||||...:
Human   244 -GGIIPNTSFCAGDEDGAFDTCRGDSGGPLMCYLPEYKRFFVMGITSYGHGCGRRGFPGVYIGPS 307

  Fly   629 SLLPWI 634
            ....|:
Human   308 FYQKWL 313

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
l(2)k05911	NP_723797.3	CLIP	111..174	CDD:197829
		PTZ00449	<198..>376	CDD:185628	11/53 (21%)
		Tryp_SPc	400..637	CDD:238113	83/251 (33%)
TMPRSS12	NP_872365.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	24..46		6/34 (18%)
		Tryp_SPc	78..316	CDD:238113	83/251 (33%)