DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Prosalpha6T and PRE5

DIOPT Version :9

Sequence 1:	NP_609623.1	Gene:	Prosalpha6T / 34726	FlyBaseID:	FBgn0032492	Length:	289	Species:	Drosophila melanogaster
Sequence 2:	NP_014045.1	Gene:	PRE5 / 855362	SGDID:	S000004931	Length:	234	Species:	Saccharomyces cerevisiae

Alignment Length:	236	Identity:	113/236 - (47%)
Similarity:	154/236 - (65%)	Gaps:	6/236 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MFRNQYDNDTTTWSPQGRLFQVEYAMEAVKQGAATVGLKGTDYAVLAALCRTSKDTNTLQRKIMP 65
            ||||.||.||.|:||.|||||||||:||:|||:.||||:...:|||.||.|.:.:.::.|:||:.
Yeast     1 MFRNNYDGDTVTFSPTGRLFQVEYALEAIKQGSVTVGLRSNTHAVLVALKRNADELSSYQKKIIK 65

  Fly    66 VDDHVGMSIAGLTADARVVCQYMRTECMAYRHSYNAEFPVRRLVSNLGNKLQTTTQRYDRRPYGV 130
            .|:|:|:|:|||..||||:..|:|.:|......:|.:..|.|....|.:|.|..||.|..|||||
Yeast    66 CDEHMGLSLAGLAPDARVLSNYLRQQCNYSSLVFNRKLAVERAGHLLCDKAQKNTQSYGGRPYGV 130

  Fly   131 GLLVAGYDEQGPHIYQVMPTANVLNCKAMAIGSRSQSARTYLERNMESF--EDCDMDELICHAIQ 193
            |||:.|||:.|.|:.:..|:.||......|||:|||.|:|||||.:::|  .|.:.||||...::
Yeast   131 GLLIIGYDKSGAHLLEFQPSGNVTELYGTAIGARSQGAKTYLERTLDTFIKIDGNPDELIKAGVE 195

  Fly   194 AIRGSLGSDD--VENLTINVAIVGKDVPFKMFTEAENQKYV 232
            ||..||..:.  |:||:|  ||||||.||.::......||:
Yeast   196 AISQSLRDESLTVDNLSI--AIVGKDTPFTIYDGEAVAKYI 234

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Prosalpha6T	NP_609623.1	PRE1	4..233	CDD:223711	110/233 (47%)
Prosalpha6T	NP_609623.1	proteasome_alpha_type_1	6..215	CDD:239718	101/212 (48%)
PRE5	NP_014045.1	Ntn_hydrolase	6..217	CDD:412394	101/212 (48%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157343184
Domainoid	1	1.000	152	1.000	Domainoid score	I920
eggNOG	1	0.900	-	-		E1_COG0638
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H2080
Inparanoid	1	1.050	213	1.000	Inparanoid score	I802
Isobase	1	0.950	-	0	Normalized mean entropy	S372
OMA	1	1.010	-	-		QHG53705
OrthoFinder	1	1.000	-	-		FOG0003679
OrthoInspector	1	1.000	-	-		otm46859
orthoMCL	1	0.900	-	-		OOG6_102143
Panther	1	1.100	-	-	O	PTHR11599
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1003
SonicParanoid	1	1.000	-	-		X2552
TreeFam	1	0.960	-	-
	16	15.740