DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment KIF24 and Kif24

DIOPT Version :9

Sequence 1:	XP_011516163.1	Gene:	KIF24 / 347240	HGNCID:	19916	Length:	1399	Species:	Homo sapiens
Sequence 2:	NP_077203.2	Gene:	Kif24 / 109242	MGIID:	1918345	Length:	1356	Species:	Mus musculus

Alignment Length:	1382	Identity:	991/1382 - (71%)
Similarity:	1099/1382 - (79%)	Gaps:	40/1382 - (2%)

- Green bases have known domain annotations that are detailed below.

Human    32 MASWLYECLCEAELAQYYSHFTALGLQKIDELAKITMKDYSKLGVHDMNDRKRLFQLIKIIKIMQ 96
            ||||||||||||||||||.|||||||||||||||:||||||:|||||||||||||||||||||||
Mouse     1 MASWLYECLCEAELAQYYPHFTALGLQKIDELAKVTMKDYSRLGVHDMNDRKRLFQLIKIIKIMQ 65

Human    97 EEDKAVSIPERHLQTSSLRIKSQELRSGPRRQLNFDSPADNKDRNASNDGFEMCSLSDFSANEQK 161
            |||||:.|||..||.|||..|.:|.||||||||:||||:.:||:.|:|   |..|||:||.:|||
Mouse    66 EEDKALGIPEHPLQASSLYTKPREFRSGPRRQLHFDSPSASKDKMANN---ETGSLSNFSVDEQK 127

Human   162 STYLKVLEHMLPDDSQYHTKTGILNATAGDSYVQTEISTSLFSPNYLSAILGDCDIPIIQRISHV 226
            ||||||||||||||||..||....:|:|.|:.:|||.:..|||.||.|..||:||||:|||:|||
Mouse   128 STYLKVLEHMLPDDSQCQTKIRAPDASAADASMQTETNAPLFSSNYFSPQLGNCDIPVIQRVSHV 192

Human   227 SGYNYGIPHSCIRQNTSEKQNPWTEMEKIRVCVRKRPLGMREVRRGEINIITVEDKETLLVHEKK 291
            |||||||||||:||.|||  |||||||||||||||||||:|||||||:|:|||||||||||||||
Mouse   193 SGYNYGIPHSCVRQITSE--NPWTEMEKIRVCVRKRPLGVREVRRGEVNVITVEDKETLLVHEKK 255

Human   292 EAVDLTQYILQHVFYFDEVFGEACTNQDVYMKTTHPLIQHIFNGGNATCFAYGQTGAGKTYTMIG 356
            ||||||||||||||||||||||||:|||||:||.|||||||||||:|||||||||||||||||||
Mouse   256 EAVDLTQYILQHVFYFDEVFGEACSNQDVYLKTAHPLIQHIFNGGSATCFAYGQTGAGKTYTMIG 320

Human   357 THENPGLYALAAKDIFRQLEVSQPRKHLFVWISFYEIYCGQLYDLLNRRKRLFAREDSKHMVQIV 421
            ||:||||||||||||||||:|||.|::|||||||||||||||||||||||||||||||||:|||.
Mouse   321 THQNPGLYALAAKDIFRQLKVSQSRRNLFVWISFYEIYCGQLYDLLNRRKRLFAREDSKHVVQIA 385

Human   422 GLQELQVDSVELLLEVILKGSKERSTGATGVNADSSRSHAVIQIQIKDSAKRTFGRISFIDLAGS 486
            ||:|||||||||||:|||||||||||||||||||||||||:||||||||||||||||||||||||
Mouse   386 GLRELQVDSVELLLQVILKGSKERSTGATGVNADSSRSHAIIQIQIKDSAKRTFGRISFIDLAGS 450

Human   487 ERAADARDSDRQTKMEGAEINQSLLALKECIRALDQEHTHTPFRQSKLTQVLKDSFIGNAKTCMI 551
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse   451 ERAADARDSDRQTKMEGAEINQSLLALKECIRALDQEHTHTPFRQSKLTQVLKDSFIGNAKTCMI 515

Human   552 ANISPSHVATEHTLNTLRYADRVKELKKGIKCCTSVTSRNRTSGNSSPKRIQSSPGALSEDKCSP 616
            |||||||:|||||||||||||||||||||:|||.|.||:|:||.|:|||||||||..|..|||||
Mouse   516 ANISPSHIATEHTLNTLRYADRVKELKKGVKCCASATSQNQTSANASPKRIQSSPVTLPGDKCSP 580

Human   617 KKVKLGFQQSLTVAAPGSTRGKVHPLTSHPPNIPFTSAPKVSGKRGGSRGSPSQEWVIHASPVKG 681
            ||||||.|||||| |||.|:.|.|||.||.||:||||.||..||:..|||||:.||.:.|||.||
Mouse   581 KKVKLGLQQSLTV-APGPTKVKAHPLASHVPNVPFTSGPKTPGKKSSSRGSPTPEWDMKASPRKG 644

Human   682 TVRSGHVAKKKPEESAPLCSEKNRMGNKTVLGWESRASGPGEGLVRGKLSTKCKKVQTVQPVQKQ 746
            |.|||| :.||..|||||||||:::|:|..:|||.|||.|||||:|.:|.|:.||||.|||||||
Mouse   645 TTRSGH-SIKKGAESAPLCSEKSQIGSKIAVGWEGRASDPGEGLLRVRLPTRGKKVQPVQPVQKQ 708

Human   747 LVSRVELSFGNAHHRAEYSQDSQRGTPARPASEAWTNIPPHQKEREEHLRFYHQQFQQPPLLQQK 811
            |:||..| ..|:|| .|.:|||:.||||..|.|||||....|||||||||||||||||||||:||
Mouse   709 LLSRPRL-LANSHH-LEATQDSKVGTPAGLAPEAWTNPILQQKEREEHLRFYHQQFQQPPLLKQK 771

Human   812 LKYQPLKRSLRQYRPPEGQLTNETPPLFHSYSENHDGAQVEELDDSDFSEDSFSHISSQRATKQR 876
            |.||||:|.|.|:||.||:|.:||....||..||.||||.|:|||||||||||||.|||.|.||.
Mouse   772 LNYQPLQRLLCQHRPSEGRLQSETGFPLHSNPENRDGAQAEDLDDSDFSEDSFSHGSSQPAMKQG 836

Human   877 NT-LENSEDSFFLHQTWGQGPEKQVAERQQS-LFSSPRTGDKKDLTKSWVDSRDP-INHRRAALD 938
            :| ||.|..||||||.....||:|.|||||. ||||...|.||....|||.|||| |:|||.||.
Mouse   837 STALERSGSSFFLHQDREHSPEEQAAERQQCLLFSSETDGSKKRPADSWVYSRDPIISHRRGALS 901

Human   939 HSCSPSKGPVDWSR-ENSTSSGPSPRDSLAEKPYCSQVDFIYRQERGGGSSFDLRKDASQSEVSG 1002
            .|.|||....|||: |:|.||||||:|:.|:||..|||||::.|:.|.....|:|.:|..|||..
Mouse   902 QSHSPSMVCPDWSKEEDSASSGPSPKDNRAQKPSSSQVDFVHHQKPGEAQVSDIRLEAFTSEVPE 966

Human  1003 ENEGNLPSPE-EDGFTISLSHVAVPGSPDQRDTVTTPLREVSADGPIQVTSTVKNGHAVPG---- 1062
            :.||:|.||. |:|.:..||||||.|||||||.|.|||||||.:   :||.|       ||
Mouse   967 QAEGSLSSPSPENGLSFPLSHVAVSGSPDQRDRVCTPLREVSEN---RVTHT-------PGRVNS 1021

Human  1063 -----EDPRGQLGTHAEYASGLMSPLTMSLLENPDNEGSPPSEQLVQDGATHSLVAESTGGPVVS 1122
                 ||...|:...:..|||||:||||||||.|.:|.....||:.||||.:..:||..|||...
Mouse  1022 STPFQEDSGEQIQMCSANASGLMAPLTMSLLETPCHEDLSSLEQIAQDGAGYGFMAEIVGGPAAG 1086

Human  1123 HTVPSGDQEAALPVSSATRHLWLSSSPPDNKPGGDLPALSPSPIRQHPADKLPSREADLGEACQS 1187
            |||||.||||||||||||..||||||||||:|.|||||||||||.||..||||.|     ||.|:
Mouse  1087 HTVPSYDQEAALPVSSATECLWLSSSPPDNRPSGDLPALSPSPIHQHSPDKLPGR-----EAYQT 1146

Human  1188 RETVLFSHEHMGSEQYDADAEETGLDGSWGFPGKPFTTIHMGVPHSGPTLTPRTGSSDVADQLWA 1252
            |..:|....||||:.||..||||.|.||..||.||.:.||.|||:|.|.||..||||:...:.||
Mouse  1147 RRPILLPENHMGSKLYDDRAEETELGGSLTFPRKPSSNIHAGVPYSTPFLTSCTGSSNGVGRPWA 1211

Human  1253 QERKHPTRLGWQEFGLSTDPIKLPCNSENVTWLKPRPISRCLARPSSPLVPSCSPKTAGTLRQPT 1317
            |||||||.:..||...|||..| |..:|::.||:.||||||| ...||:|||||.|...|....|
Mouse  1212 QERKHPTGVSCQELVSSTDSNK-PHYNEDIAWLRHRPISRCL-DSDSPVVPSCSSKALRTYCPLT 1274

Human  1318 LEQAQQVVIRAHQEQLDEMAELGFKEETLMSQLASNDFEDFVTQLDEIMVLKSKCIQSLRSQLQL 1382
            .||||||:||||:|||||||||..||||||:|:.|||||||||||||||.|||:|||||||||||
Mouse  1275 PEQAQQVIIRAHKEQLDEMAELDLKEETLMTQMDSNDFEDFVTQLDEIMALKSRCIQSLRSQLQL 1339

Human  1383 YLTCHGPTAAPEGTVPS 1399
            |||.|.|.||||.||.|
Mouse  1340 YLTSHRPAAAPERTVVS 1356

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
KIF24	XP_011516163.1	SAM_KIF24-like	34..93	CDD:188940	55/58 (95%)
		KISc_KIF2_like	254..575	CDD:276818	302/320 (94%)
		Kinesin	260..576	CDD:278646	297/315 (94%)
Kif24	NP_077203.2	SAM_KIF24-like	3..62	CDD:188940	55/58 (95%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	93..119		16/28 (57%)
		KISc_KIF2_like	218..539	CDD:276818	302/320 (94%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	552..581		20/28 (71%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	597..664		42/67 (63%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	788..840		34/51 (67%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	897..947		28/49 (57%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	964..998		19/33 (58%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1109..1140		25/30 (83%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C83951599
Domainoid	1	1.000	921	1.000	Domainoid score	I2072
eggNOG	0	0.000	Not matched by this tool.
HGNC	1	1.500	-	-
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H52346
Inparanoid	1	1.050	1860	1.000	Inparanoid score	I1895
Isobase	1	0.950	-	0	Normalized mean entropy	S12009
NCBI	1	1.000	-	-
OMA	1	1.010	-	-		QHG35817
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0009890
OrthoInspector	1	1.000	-	-		oto122420
orthoMCL	1	0.900	-	-		OOG6_100492
Panther	1	1.100	-	-	LDO	PTHR47971
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R12933
SonicParanoid	1	1.000	-	-		X11314
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	17	17.340