DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ski6 and EXOSC4

DIOPT Version :9

Sequence 1:	NP_001260437.1	Gene:	Ski6 / 34721	FlyBaseID:	FBgn0032487	Length:	246	Species:	Drosophila melanogaster
Sequence 2:	NP_061910.1	Gene:	EXOSC4 / 54512	HGNCID:	18189	Length:	245	Species:	Homo sapiens

Alignment Length:	238	Identity:	127/238 - (53%)
Similarity:	169/238 - (71%)	Gaps:	7/238 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSGKYDLLSEQGLRLDGRRPHELRRIKCKLGVFEQPDGSAYMEQGNTKVLAAVYGPHQAKGNQT- 64
            |:| .:|||:||.|:||||..|||:|:.::|||.|.|||||:||||||.||.|||||:.:|::.
Human     1 MAG-LELLSDQGYRVDGRRAGELRKIQARMGVFAQADGSAYIEQGNTKALAVVYGPHEIRGSRAR 64

  Fly    65 ----ESVINCQYSQATFSTAERKNRPRGDRKSLEFKLYLQQALSAAIKSELYPRSQIDIYVEVLQ 125
                .:::|||||.|||||.|||.||.|||||.|..|.|:|...|||.::|:|||||||||:|||
Human    65 ALPDRALVNCQYSSATFSTGERKRRPHGDRKSCEMGLQLRQTFEAAILTQLHPRSQIDIYVQVLQ 129

  Fly   126 DDGANYAVALNAATLALIDAGICLNEFIVACTASLSKSNIPLTDISQFEEVSGGPKLTVAALPTA 190
            .||..||..:||||||::||||.:.:|:.||:|.. .....|.|:|..||.:|||:|.:|.||.:
Human   130 ADGGTYAACVNAATLAVLDAGIPMRDFVCACSAGF-VDGTALADLSHVEEAAGGPQLALALLPAS 193

  Fly   191 EKIAFLEMSERFHIDHLETVIETAMAGCREIRDILEAAVKEHL 233
            .:||.|||..|.|.||||.|:|.|....|::..:|:..|::|:
Human   194 GQIALLEMDARLHEDHLERVLEAAAQAARDVHTLLDRVVRQHV 236

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ski6	NP_001260437.1	PRK03983	7..231	CDD:235187	124/228 (54%)
Ski6	NP_001260437.1	RNase_PH_RRP41	12..233	CDD:206775	120/225 (53%)
EXOSC4	NP_061910.1	RNase_PH_RRP41	11..237	CDD:206775	121/227 (53%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165152421
Domainoid	1	1.000	166	1.000	Domainoid score	I3912
eggNOG	1	0.900	-	-		E1_COG0689
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H6017
Inparanoid	1	1.050	252	1.000	Inparanoid score	I3220
Isobase	1	0.950	-	0	Normalized mean entropy	S936
OMA	1	1.010	-	-		QHG53663
OrthoDB	1	1.010	-	-		D1394468at2759
OrthoFinder	1	1.000	-	-		FOG0001991
OrthoInspector	1	1.000	-	-		oto89577
orthoMCL	1	0.900	-	-		OOG6_101074
Panther	1	1.100	-	-	LDO	PTHR11953
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1218
SonicParanoid	1	1.000	-	-		X3242
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	17	16.750