Protein Alignment mRF1 and MTRF1L

DIOPT Version :10

• Sequence 1: NP_609617.1
• Gene: mRF1 / 34720
• FlyBaseID: FBgn0032486
• Length: 392
• Species: Drosophila melanogaster
• Sequence 2: NP_061914.3
• Gene: MTRF1L / 54516
• HGNCID: 21051
• Length: 380
• Species: Homo sapiens
• Alignment Length: 375
• Identity: 161/375 - (42%)
• Similarity: 231/375 - (61%)
• Gaps: 26/375 - (6%)

  Fly    15 ARRWAST-----DPLSIQNEKLQAYLESLRQEYYAVRVNAAGNSKSYARLAQLEGVVSALEQRRV 74
            |||..|:     :.|..:...|:.:||  ||        |...:....|..:|..|:..|.::
Human    22 ARRPLSSGSPPLEELFTRGGPLRTFLE--RQ--------AGSEAHLKVRRPELLAVIKLLNEK-- 74

  Fly    75 LERHITSAKDMEAEKDEDMRELMREENEVYV---DLLGKQDQALLQELLTLSDDEEYPALIFGLN 136
             ||.:...:.:..:::||:|:|  .|||:.:   ::...:.|.:|  ||..|::.:...||..:.
Human    75 -ERELRETEHLLHDENEDLRKL--AENEITLCQKEITQLKHQIIL--LLVPSEETDENDLILEVT 134

  Fly   137 AGAGGQEAMLFAQELYEMYTGYFEHMGWEWEEFASEGTDIGGLRHASLMVSGEDAFRWLRYEAGV 201
            ||.||||||||..|:::||..|.....|.:|......:::|||||||..:.|.:|:|.:::|.||
Human   135 AGVGGQEAMLFTSEIFDMYQQYAAFKRWHFETLEYFPSELGGLRHASASIGGSEAYRHMKFEGGV 199

  Fly   202 HRVQRVPATEKSGRMHTSTASITVIPRPADIQVHIAEKDLKIETKRASGAGGQHVNTTDSAVRIV 266
            |||||||.|||.||:||||.::.::|:|.:|.:.|..|||:|:||||||||||||||||||||||
Human   200 HRVQRVPKTEKQGRVHTSTMTVAILPQPTEINLVINPKDLRIDTKRASGAGGQHVNTTDSAVRIV 264

  Fly   267 HLPTGLAVEAQSERSQLKNRELAMKRLRSRLVQQQLESVEASKMATKKAQQGSLNRNEKIRTYNF 331
            |||||:..|.|.|||||||:||||.:||::|....||.....:...:|.|.||..|:||||||||
Human   265 HLPTGVVSECQQERSQLKNKELAMTKLRAKLYSMHLEEEINKRQNARKIQIGSKGRSEKIRTYNF 329

  Fly   332 VQDRITDHRIQGGTLHNLNGFLKGGDQLSGLIEKLQLEHRRERLKELLDR 381
            .|:|:||||| ..|||:|..|::|...|..|::.|:.....|.|.|::.:
Human   330 PQNRVTDHRI-NKTLHDLETFMQGDYLLDELVQSLKEYADYESLVEIISQ 378

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mRF1	NP_609617.1	PrfA	35..378	CDD:439986	154/345 (45%)
MTRF1L	NP_061914.3	PrfA	63..366	CDD:439986	146/310 (47%)
		GGQ domain. /evidence=ECO:0000250|UniProtKB:Q80VP5	236..300		47/63 (75%)
		GGQ. /evidence=ECO:0000269|PubMed:37141370	250..252		1/1 (100%)