DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mRF1 and MTRF1L

DIOPT Version :9

Sequence 1:	NP_609617.1	Gene:	mRF1 / 34720	FlyBaseID:	FBgn0032486	Length:	392	Species:	Drosophila melanogaster
Sequence 2:	NP_061914.3	Gene:	MTRF1L / 54516	HGNCID:	21051	Length:	380	Species:	Homo sapiens

Alignment Length:	375	Identity:	161/375 - (42%)
Similarity:	231/375 - (61%)	Gaps:	26/375 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 ARRWAST-----DPLSIQNEKLQAYLESLRQEYYAVRVNAAGNSKSYARLAQLEGVVSALEQRRV 74
            |||..|:     :.|..:...|:.:||  ||        |...:....|..:|..|:..|.::
Human    22 ARRPLSSGSPPLEELFTRGGPLRTFLE--RQ--------AGSEAHLKVRRPELLAVIKLLNEK-- 74

  Fly    75 LERHITSAKDMEAEKDEDMRELMREENEVYV---DLLGKQDQALLQELLTLSDDEEYPALIFGLN 136
             ||.:...:.:..:::||:|:|  .|||:.:   ::...:.|.:|  ||..|::.:...||..:.
Human    75 -ERELRETEHLLHDENEDLRKL--AENEITLCQKEITQLKHQIIL--LLVPSEETDENDLILEVT 134

  Fly   137 AGAGGQEAMLFAQELYEMYTGYFEHMGWEWEEFASEGTDIGGLRHASLMVSGEDAFRWLRYEAGV 201
            ||.||||||||..|:::||..|.....|.:|......:::|||||||..:.|.:|:|.:::|.||
Human   135 AGVGGQEAMLFTSEIFDMYQQYAAFKRWHFETLEYFPSELGGLRHASASIGGSEAYRHMKFEGGV 199

  Fly   202 HRVQRVPATEKSGRMHTSTASITVIPRPADIQVHIAEKDLKIETKRASGAGGQHVNTTDSAVRIV 266
            |||||||.|||.||:||||.::.::|:|.:|.:.|..|||:|:||||||||||||||||||||||
Human   200 HRVQRVPKTEKQGRVHTSTMTVAILPQPTEINLVINPKDLRIDTKRASGAGGQHVNTTDSAVRIV 264

  Fly   267 HLPTGLAVEAQSERSQLKNRELAMKRLRSRLVQQQLESVEASKMATKKAQQGSLNRNEKIRTYNF 331
            |||||:..|.|.|||||||:||||.:||::|....||.....:...:|.|.||..|:||||||||
Human   265 HLPTGVVSECQQERSQLKNKELAMTKLRAKLYSMHLEEEINKRQNARKIQIGSKGRSEKIRTYNF 329

  Fly   332 VQDRITDHRIQGGTLHNLNGFLKGGDQLSGLIEKLQLEHRRERLKELLDR 381
            .|:|:||||| ..|||:|..|::|...|..|::.|:.....|.|.|::.:
Human   330 PQNRVTDHRI-NKTLHDLETFMQGDYLLDELVQSLKEYADYESLVEIISQ 378

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mRF1	NP_609617.1	prfA	35..378	CDD:234801	154/345 (45%)
		PCRF	58..222	CDD:281461	65/166 (39%)
		RF-1	234..338	CDD:278876	65/103 (63%)
MTRF1L	NP_061914.3	PCRF	63..221	CDD:281461	64/164 (39%)
		PrfB	130..353	CDD:224107	124/223 (56%)
		RF-1	231..336	CDD:278876	65/104 (63%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	139	1.000	Domainoid score	I4791
eggNOG	1	0.900	-	-		E1_COG0216
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H5905
Inparanoid	1	1.050	275	1.000	Inparanoid score	I2972
Isobase	1	0.950	-	0	Normalized mean entropy	S1289
OMA	1	1.010	-	-		QHG62484
OrthoDB	1	1.010	-	-		D1313171at2759
OrthoFinder	1	1.000	-	-		FOG0001423
OrthoInspector	1	1.000	-	-		otm41346
orthoMCL	1	0.900	-	-		OOG6_101033
Panther	1	1.100	-	-	LDO	PTHR43804
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1085
SonicParanoid	1	1.000	-	-		X991
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	16	15.820