DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mRF1 and Mtrf1l

DIOPT Version :9

Sequence 1:	NP_609617.1	Gene:	mRF1 / 34720	FlyBaseID:	FBgn0032486	Length:	392	Species:	Drosophila melanogaster
Sequence 2:	NP_001020894.1	Gene:	Mtrf1l / 361473	RGDID:	1598312	Length:	373	Species:	Rattus norvegicus

Alignment Length:	388	Identity:	166/388 - (42%)
Similarity:	237/388 - (61%)	Gaps:	32/388 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 LRLGYL--ARR-WA---------STDPLSIQNEKLQAYLESLRQEYYAVRVNAAGNSKSYARLAQ 61
            :|.|:|  ||| ||         .::.|..:...|:|:||.        ||.:...... |...|
  Rat     1 MRSGFLRSARRLWARRAISRMPPPSEELLARGGPLRAFLER--------RVGSEAGGLD-AGSPQ 56

  Fly    62 LEGVVSALEQRRVLERHITSAKDMEAEKDEDMRELMREENEVYVDLLGKQDQALLQELLTL---S 123
            |......|.::   ||.:...:.:..:::||:::|...|    :.|..|:...|...:::|   |
  Rat    57 LAAAARLLNEK---ERELRDTESLLHDENEDLKKLAESE----IALCQKEIAELKHRIISLLVPS 114

  Fly   124 DDEEYPALIFGLNAGAGGQEAMLFAQELYEMYTGYFEHMGWEWEEFASEGTDIGGLRHASLMVSG 188
            :|.:...||..:.||.||||||||..|:::||..|.....|.:|......:::|||||||..:.|
  Rat   115 EDMDGSDLILEVTAGVGGQEAMLFTSEMFDMYQQYAAFKRWHFETLEYFPSELGGLRHASASIGG 179

  Fly   189 EDAFRWLRYEAGVHRVQRVPATEKSGRMHTSTASITVIPRPADIQVHIAEKDLKIETKRASGAGG 253
            .:|:|.:::|.|||||||||.||:.||:||||.::.::|:|.:|::.|..|||:|:|||||||||
  Rat   180 PEAYRHMKFEGGVHRVQRVPKTERQGRIHTSTMTVAILPQPTEIKLVINPKDLRIDTKRASGAGG 244

  Fly   254 QHVNTTDSAVRIVHLPTGLAVEAQSERSQLKNRELAMKRLRSRLVQQQLESVEASKMATKKAQQG 318
            ||||||||||||||||||:..|.|.|||||||||||||:||:||...:||...|.:.:.:|.|.|
  Rat   245 QHVNTTDSAVRIVHLPTGIISECQQERSQLKNRELAMKKLRARLYSMRLEEETAKRYSARKIQVG 309

  Fly   319 SLNRNEKIRTYNFVQDRITDHRIQGGTLHNLNGFLKGGDQLSGLIEKLQLEHRRERLKELLDR 381
            :..|:||||||||.|:|:||||| ..:||:|..|::|...|..||:.|:.....|.|.|::.|
  Rat   310 TKGRSEKIRTYNFPQNRVTDHRI-NKSLHDLESFMQGDCLLDDLIQSLKDYSDYESLVEMISR 371

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mRF1	NP_609617.1	prfA	35..378	CDD:234801	153/345 (44%)
		PCRF	58..222	CDD:281461	61/166 (37%)
		RF-1	234..338	CDD:278876	68/103 (66%)
Mtrf1l	NP_001020894.1	PCRF	57..214	CDD:281461	60/163 (37%)
		PrfB	123..355	CDD:224107	129/232 (56%)
		RF-1	224..329	CDD:278876	68/104 (65%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	148	1.000	Domainoid score	I4339
eggNOG	1	0.900	-	-		E1_COG0216
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H5905
Inparanoid	1	1.050	282	1.000	Inparanoid score	I2804
OMA	1	1.010	-	-		QHG62484
OrthoDB	1	1.010	-	-		D1313171at2759
OrthoFinder	1	1.000	-	-		FOG0001423
OrthoInspector	1	1.000	-	-		otm45473
orthoMCL	1	0.900	-	-		OOG6_101033
Panther	1	1.100	-	-	LDO	PTHR43804
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X991
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	14	13.840