DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mRF1 and Mtrf1

DIOPT Version :9

Sequence 1:	NP_609617.1	Gene:	mRF1 / 34720	FlyBaseID:	FBgn0032486	Length:	392	Species:	Drosophila melanogaster
Sequence 2:	XP_017171428.1	Gene:	Mtrf1 / 211253	MGIID:	2384815	Length:	462	Species:	Mus musculus

Alignment Length:	375	Identity:	140/375 - (37%)
Similarity:	218/375 - (58%)	Gaps:	23/375 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 QNEKLQAYLESLRQEYYAVRVNAAGNSKS----------YARLAQLEGVVSAL-EQRRVLERHIT 80
            :::.||.|:|.|.:||..:.....|.|::          :|:||.|..|...: |..:.:|...:
Mouse    83 KHKALQKYMEDLNKEYQTLDQCLQGISENEGDRRALHRRHAQLAPLAAVYQEIQEAEQAIEELES 147

  Fly    81 SAKDMEAEKDEDMRELMREENEVYVDLLGKQDQALLQELLTLSDDEEYPALIFGLNAG--AGGQE 143
            ..|.:..:.::.::||:.||.::....:.:....||:.|:. .:..::..:|..:.:|  .||..
Mouse   148 LCKSLNKQDEKQLQELVSEERQIIDQKIHRLYSELLERLVP-KEKYDWSDVILEVTSGRTTGGDI 211

  Fly   144 AMLFAQELYEMYTGYFEHMGWEWEEFASEGTDIGGLRHASLMVSGEDAFRWLRYEAGVHRVQRVP 208
            ...|.:|:::||..|..:..|::|.......|.|||.||:..:||:..::.|:||.|:|||||:|
Mouse   212 CQQFTREIFDMYQNYSYYKHWKFELLNYTPADYGGLHHAAARISGDSVYKHLKYEGGIHRVQRIP 276

  Fly   209 ATEKSGRM---HTSTASITVIPRPADI-----QVHIAEKDLKIETKRASGAGGQHVNTTDSAVRI 265
            ....|.||   ||.|.|:.|:|:|.::     .|.:..|||:::|.||.|||||||||||||||:
Mouse   277 EVGLSSRMQRIHTGTMSVIVLPQPDEVTSPGQDVKVDPKDLRVDTFRARGAGGQHVNTTDSAVRL 341

  Fly   266 VHLPTGLAVEAQSERSQLKNRELAMKRLRSRLVQQQLESVEASKMATKKAQQGSLNRNEKIRTYN 330
            ||:||||.||.|.|||||||:|:|::.||:||.||.:|.....:...:|.|.|:..::|:|||||
Mouse   342 VHIPTGLVVECQQERSQLKNKEIALRVLRARLYQQIIEKDRCQQQNARKLQVGTRAQSERIRTYN 406

  Fly   331 FVQDRITDHRIQGGTLHNLNGFLKGGDQLSGLIEKLQLEHRRERLKELLD 380
            |.|||:||||| ...:.::..||:|...|..|||:|......|.:.|.||
Mouse   407 FTQDRVTDHRI-AYEVRDIKEFLRGEKCLDQLIERLLQSADEEAISEFLD 455

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mRF1	NP_609617.1	prfA	35..378	CDD:234801	134/363 (37%)
		PCRF	58..222	CDD:281461	49/169 (29%)
		RF-1	234..338	CDD:278876	60/103 (58%)
Mtrf1	XP_017171428.1	prfA	116..452	CDD:234801	128/337 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	146	1.000	Domainoid score	I4523
eggNOG	1	0.900	-	-		E1_COG0216
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	283	1.000	Inparanoid score	I2853
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG62484
OrthoDB	1	1.010	-	-		D1313171at2759
OrthoFinder	1	1.000	-	-		FOG0001423
OrthoInspector	1	1.000	-	-		otm43404
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR43804
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X991
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	10	9.980