DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mRF1 and Mtrf1l

DIOPT Version :9

Sequence 1:	NP_609617.1	Gene:	mRF1 / 34720	FlyBaseID:	FBgn0032486	Length:	392	Species:	Drosophila melanogaster
Sequence 2:	NP_780583.1	Gene:	Mtrf1l / 108853	MGIID:	1918830	Length:	373	Species:	Mus musculus

Alignment Length:	388	Identity:	168/388 - (43%)
Similarity:	237/388 - (61%)	Gaps:	32/388 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 LRLGYL--ARR-WA---------STDPLSIQNEKLQAYLESLRQEYYAVRVNAAGNSKSYARLAQ 61
            :|.|:|  ||| ||         .::.|..:...|:|:||.      .|...|.|....|.:||.
Mouse     1 MRSGFLSGARRLWARRAFSRTPPPSEELLARGGPLRAFLER------RVGSEAGGLDAGYPQLAA 59

  Fly    62 LEGVVSALEQRRVLERHITSAKDMEAEKDEDMRELMREENEVYVDLLGKQDQALLQELLTL---S 123
            ...::|.      .||.:...:.:..:::||:::|...|    :.|..||...|..::::|   |
Mouse    60 AARLLSE------KERELRDTESLLHDENEDLKKLAESE----IALCQKQITELKHQIISLLVPS 114

  Fly   124 DDEEYPALIFGLNAGAGGQEAMLFAQELYEMYTGYFEHMGWEWEEFASEGTDIGGLRHASLMVSG 188
            ::.:...||..:.||.||||||||..|:::||..|.....|.:|......:::|||||||..|.|
Mouse   115 EEMDGSDLILEVTAGVGGQEAMLFTSEMFDMYQQYAAFKRWHFETLEYFPSELGGLRHASASVGG 179

  Fly   189 EDAFRWLRYEAGVHRVQRVPATEKSGRMHTSTASITVIPRPADIQVHIAEKDLKIETKRASGAGG 253
            .:|:|.:::|.|||||||||.|||.||:||||.::.::|:|.:|::.|..|||:|:|||||||||
Mouse   180 PEAYRHMKFEGGVHRVQRVPKTEKQGRIHTSTMTVAILPQPTEIKLVINPKDLRIDTKRASGAGG 244

  Fly   254 QHVNTTDSAVRIVHLPTGLAVEAQSERSQLKNRELAMKRLRSRLVQQQLESVEASKMATKKAQQG 318
            ||||||||||||||||||:..|.|.|||||||||||||:||:||....||...|.:...:|.|.|
Mouse   245 QHVNTTDSAVRIVHLPTGIISECQQERSQLKNRELAMKKLRARLYSMHLEEETAKRYNARKIQVG 309

  Fly   319 SLNRNEKIRTYNFVQDRITDHRIQGGTLHNLNGFLKGGDQLSGLIEKLQLEHRRERLKELLDR 381
            :..|:||||||||.|:|:||||| ..:||:|..|::|...|..:|:.|:.....|.|.|::.|
Mouse   310 TKGRSEKIRTYNFPQNRVTDHRI-NKSLHDLESFMQGDCLLDDMIQSLKDCSDYEALVEMISR 371

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mRF1	NP_609617.1	prfA	35..378	CDD:234801	155/345 (45%)
		PCRF	58..222	CDD:281461	63/166 (38%)
		RF-1	234..338	CDD:278876	68/103 (66%)
Mtrf1l	NP_780583.1	PCRF	57..214	CDD:281461	63/166 (38%)
		PrfB	123..355	CDD:224107	130/232 (56%)
		RF-1	224..329	CDD:278876	68/104 (65%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	146	1.000	Domainoid score	I4523
eggNOG	1	0.900	-	-		E1_COG0216
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H5905
Inparanoid	1	1.050	283	1.000	Inparanoid score	I2853
Isobase	1	0.950	-	0	Normalized mean entropy	S1289
OMA	1	1.010	-	-		QHG62484
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001423
OrthoInspector	1	1.000	-	-		otm43404
orthoMCL	1	0.900	-	-		OOG6_101033
Panther	1	1.100	-	-	LDO	PTHR43804
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1085
SonicParanoid	1	1.000	-	-		X991
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	15	14.810