DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG9426 and Klhl1

DIOPT Version :9

Sequence 1:	NP_609616.1	Gene:	CG9426 / 34719	FlyBaseID:	FBgn0032485	Length:	627	Species:	Drosophila melanogaster
Sequence 2:	NP_444335.2	Gene:	Klhl1 / 93688	MGIID:	2136335	Length:	751	Species:	Mus musculus

Alignment Length:	619	Identity:	197/619 - (31%)
Similarity:	307/619 - (49%)	Gaps:	65/619 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    41 GQNLGSGATAASH----RTNLPSYC---------NAQYPFKVLSNLNQLREQSRFCDVEIIAGMA 92
            |:..|...|:.:|    :::|.|..         :|:..|:.:.|   ..:|.:.|||.:|.|..
Mouse   163 GEGCGHRLTSTNHSLTPQSDLDSSSSEEFYQAVHHAEQSFRKMEN---YLKQQQLCDVILIVGNR 224

  Fly    93 TLSAHRAVLSAASAYFEAMFRPELGLNEVKQKSVVLHTIDGDILHILLDFIYTGRCEITQSNVQE 157
            .:.|||.|||:.|.||.|||..:  :.|.||:.:.:..||.:.|..|:.|.|||..|:.:..::.
Mouse   225 KIPAHRLVLSSVSDYFAAMFTSD--VCEAKQEEIKMEGIDPNALWDLVQFAYTGCLELKEDTIEN 287

  Fly   158 LLAAADMLQLNEVVDGCCEFLCRELHASNALGILRFAEAHNCESLAKSALNFVHANFPAVTLEDE 222
            |||||.:|||.:||:.||.||.:.||.||.|||..||:|..|..|.|.|.::...|...|....|
Mouse   288 LLAAACLLQLPQVVEVCCHFLMKLLHPSNCLGIRAFADAQGCIELMKVAHSYTMENIMEVIRNQE 352

  Fly   223 FLETPQTLLSQLLNSELLRVDSESQVFQAALRWIKHDVTQRRCYVFD-VLSHVRMALVPVKVI-- 284
            ||..|...|.:||.|:.:.|..|..:|.|.:.|:|:|: ||||.... :|:.:|:.|:|.:::
Mouse   353 FLLLPAEELHKLLASDDVNVPDEETIFHALMMWVKYDM-QRRCSDLSMLLAFIRLPLLPPQILAD 416

  Fly   285 --DKAL-KDD--CRDMSVKIALRSICRDIASKRGQLVPL-RVCPRQLAKKNIYIIGGSHRDTPRT 343
              :.|| |:|  |:    |:.|.::...:..:|..|:.. |..||:.....:|.:||...:...|
Mouse   417 LENHALFKNDLECQ----KLILEAMKYHLLPERRTLMQSPRTKPRKSTVGTLYAVGGMDNNKGAT 477

  Fly   344 WNSADCIFETVAKFDIFRREWTETAPMEVGRILPGVSALNGKIYVVGGERGSQILANGEVYDPQN 408
                     |:.|:|:....|.:...|...|:..||:.::.|::|:||..|.:.|...|.|:|:.
Mouse   478 ---------TIEKYDLRTNLWIQAGMMNGRRLQFGVAVIDDKLFVIGGRDGLKTLNTVECYNPKT 533

  Fly   409 DVWQPIAPMIVPRCEFGLCTMGGNLFAVGGWIGDDIGGSMECYDPEQDLWKLMGSMPQPRFSMGV 473
            ..|..:.||...|...|:..:.|.::||||..|.....::|.:||:...|..:.||...|.::||
Mouse   534 KTWTVLPPMSTHRHGLGVTVLEGPIYAVGGHDGWSYLNTVERWDPQSQQWTYVASMSIARSTVGV 598

  Fly   474 VSFEGLIYIVGG-----CTTTTRHLPDLISFNPVTKEWNELARMQTARCQMGVAVLDRYLYVVGG 533
            .:..|.:|.|||     |.::..:      ::|.|.:|:..|.|...|..:|||..|.:||.|||
Mouse   599 AALNGKLYSVGGRDGSSCLSSMEY------YDPHTNKWSMCAPMCKRRGGVGVATCDGFLYAVGG 657

  Fly   534 -----SSISQDILSSVERYSFDEDKWTTVCALNVPRAIPAVVAADGLLYVAGGDQPCEVNFYRAQ 593
                 |:....:|..||||....|.||.|..|::||....|......||..||        |..|
Mouse   658 HDAPASNHCSRLLDYVERYDPKTDTWTMVAPLSMPRDAVGVCLLGDRLYAVGG--------YDGQ 714

  Fly   594 VTINAVECYDPLSDTWKNCPDLPVSRSEAGAVVV 627
            ..:|.:|.|||.::.|.....|.:.|:.|..||:
Mouse   715 TYLNTMESYDPQTNEWTQMASLNIGRAGACVVVI 748

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9426	NP_609616.1	BTB	73..179	CDD:279045	43/105 (41%)
		PHA03098	78..558	CDD:222983	166/498 (33%)
		BACK	187..289	CDD:285009	37/107 (35%)
		Kelch	330..384	CDD:128874	12/53 (23%)
		KELCH repeat	374..417	CDD:276965	13/42 (31%)
		Kelch	385..431	CDD:128874	14/45 (31%)
		KELCH repeat	421..465	CDD:276965	13/43 (30%)
		Kelch	<447..478	CDD:128874	9/30 (30%)
		Kelch_6	467..516	CDD:290672	14/53 (26%)
		KELCH repeat	468..512	CDD:276965	13/48 (27%)
		Kelch_1	515..557	CDD:279660	19/46 (41%)
		KELCH repeat	516..561	CDD:276965	20/49 (41%)
		KELCH repeat	564..617	CDD:276965	15/52 (29%)
		Kelch	575..627	CDD:128874	16/51 (31%)
Klhl1	NP_444335.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	25..54
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	69..98
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	157..184		4/20 (20%)
		BTB	205..308	CDD:279045	43/107 (40%)
		PHA03098	209..731	CDD:222983	182/551 (33%)
		BACK	317..416	CDD:285009	35/99 (35%)
		Kelch 1	463..509		12/54 (22%)
		Kelch	464..509	CDD:128874	12/53 (23%)
		Kelch_1	498..543	CDD:279660	14/44 (32%)
		KELCH repeat	499..542	CDD:276965	13/42 (31%)
		Kelch 2	510..556		14/45 (31%)
		KELCH repeat	546..590	CDD:276965	13/43 (30%)
		Kelch	558..603	CDD:128874	14/44 (32%)
		Kelch 3	558..603		14/44 (32%)
		KELCH repeat	593..636	CDD:276965	13/48 (27%)
		Kelch	604..650	CDD:128874	14/51 (27%)
		Kelch 4	604..650		14/51 (27%)
		KELCH repeat	640..690	CDD:276965	20/49 (41%)
		Kelch	652..703	CDD:128874	19/50 (38%)
		Kelch 5	652..703		19/50 (38%)
		KELCH repeat	693..737	CDD:276965	14/51 (27%)
		Kelch 6	704..750		17/53 (32%)
		Kelch	704..748	CDD:128874	16/51 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4441
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D312716at33208
OrthoFinder	1	1.000	-	-		FOG0000036
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X9
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.820