Protein Alignment CG9426 and Klhl5

DIOPT Version :10

• Sequence 1: NP_609616.1
• Gene: CG9426 / 34719
• FlyBaseID: FBgn0032485
• Length: 627
• Species: Drosophila melanogaster
• Sequence 2: NP_780383.2
• Gene: Klhl5 / 71778
• MGIID: 1919028
• Length: 708
• Species: Mus musculus
• Alignment Length: 616
• Identity: 193/616 - (31%)
• Similarity: 308/616 - (50%)
• Gaps: 68/616 - (11%)

  Fly    46 SGATAASHRTNLPSYCNAQYP------FKVLSNL--------NQLREQSRFCDVEIIAGMATLSA 96
            |.::..|:.:...|.|.|..|      |:.|::.        |.||.: :.|||.::||...:.|
Mouse   123 SSSSRTSNSSQTLSSCQAMEPCSSDEFFQALNHAEQTFKKMENYLRHK-QLCDVILVAGDRRIPA 186

  Fly    97 HRAVLSAASAYFEAMFRPELGLNEVKQKSVVLHTIDGDILHILLDFIYTGRCEITQSNVQELLAA 161
            ||.|||:.|.||.|||..:  :.|.:|:.:.:..::.:.|..|:.:.||||.|:.:.|::.||:.
Mouse   187 HRLVLSSVSDYFAAMFTND--VREARQEEIKMEGVEPNSLWSLIQYAYTGRLELKEDNIECLLST 249

  Fly   162 ADMLQLNEVVDGCCEFLCRELHASNALGILRFAEAHNCESLAKSALNFVHANFPAVTLEDEFLET 226
            |.:|||::||:.||:||.::||.||.|||..||:|..|..|.|.|.|:...:|..|....||:..
Mouse   250 ACLLQLSQVVEACCKFLMKQLHPSNCLGIRSFADAQGCTDLHKVAHNYTMEHFMEVIRNQEFVLL 314

  Fly   227 PQTLLSQLLNSELLRVDSESQVFQAALRWIKHDVTQRRCYVFDVLSHVRMALVPVKVI----DKA 287
            |...:::||.|:.:.:.:|..:..|.|.|::||:.|||..:..:|:::|:.|:..:.:    :.|
Mouse   315 PANEIAKLLASDDMNIPNEETILNALLTWVRHDLEQRRKDLSRLLAYIRLPLLAPQFLADMENNA 379

  Fly   288 L-KDD--CRDM---SVKIALRSICRDIASKRGQLVPLRVCPRQLAKKNIYIIGGSHRDTPRTWNS 346
            | :||  |:.:   ::|..|      :..:|..|...|..||:.....::.:||.......|
Mouse   380 LFRDDIECQKLIMEAMKYHL------LPERRPMLQSPRTKPRKSTVGTLFAVGGMDSTKGAT--- 435

  Fly   347 ADCIFETVAKFDIFRREWTETAPMEVGRILPGVSALNGKIYVVGGERGSQILANGEVYDPQNDVW 411
                  ::.|:|:....||..|.|...|:..||:.|:.|:|||||..|.:.|...|.|:|:...|
Mouse   436 ------SIEKYDLRTNMWTPVANMNGRRLQFGVAVLDDKLYVVGGRDGLKTLNTVECYNPKTKTW 494

  Fly   412 QPIAPMIVPRCEFGLCTMGGNLFAVGGWIGDDIGGSMECYDPEQDLWKLMGSMPQPRFSMGVVSF 476
            ..:.||...|...|:..:.|.::||||..|.....::|.:||:...|..:.:|..||.::||...
Mouse   495 SVMPPMSTHRHGLGVAVLEGPMYAVGGHDGWSYLNTVERWDPQARQWNFVATMSTPRSTVGVAVL 559

  Fly   477 EGLIYIVGG-----CTTTTRHLPDLISFNPVTKEWNELARMQTARCQMGVAVLDRYLYVVGG--- 533
            .|.:|.|||     |      |..:..|:|.|.:|...|:|...|..:||...:..||.:||
Mouse   560 SGKLYAVGGRDGSSC------LKSVECFDPHTNKWTLCAQMSKRRGGVGVTTWNGLLYAIGGHDA 618

  Fly   534 --SSISQDILSSVERYSFDEDKWTTVCALNVPRAIPAVVAADGLLYVAGGDQPCEVNFYRAQVTI 596
              |:::..:...||||....|.||.|.:::|.|....|......||..||        |..|..:
Mouse   619 PTSNLTSRLSDCVERYDPKTDVWTAVASMSVSRDAVGVCLLGDKLYAVGG--------YDGQTYL 675

  Fly   597 NAVECYDPLSDTWKNCPDLPVSRSEAGAVVV 627
            |.||.|||.::.|.....|.:.|  |||.||
Mouse   676 NIVEAYDPQTNEWTQVAPLCLGR--AGACVV 704

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG9426	NP_609616.1	BTB_POZ_KLHL27_IPP	63..189	CDD:349565	50/139 (36%)
		PHA03098	78..558	CDD:222983	158/499 (32%)
		KELCH repeat	374..417	CDD:276965	16/42 (38%)
		KELCH repeat	421..465	CDD:276965	12/43 (28%)
		KELCH repeat	468..512	CDD:276965	15/48 (31%)
		KELCH repeat	516..561	CDD:276965	16/49 (33%)
		KELCH repeat	564..617	CDD:276965	16/52 (31%)
		Kelch	575..627	CDD:128874	18/51 (35%)
Klhl5	NP_780383.2	PHA03098	173..695	CDD:222983	175/552 (32%)
		KELCH repeat	457..500	CDD:276965	16/42 (38%)
		KELCH repeat	504..548	CDD:276965	12/43 (28%)
		KELCH repeat	551..594	CDD:276965	15/48 (31%)
		KELCH repeat	598..648	CDD:276965	16/49 (33%)
		KELCH repeat	651..694	CDD:276965	15/50 (30%)