DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment CG9426 and KLHL12

DIOPT Version :9

Sequence 1:NP_609616.1 Gene:CG9426 / 34719 FlyBaseID:FBgn0032485 Length:627 Species:Drosophila melanogaster
Sequence 2:XP_011508137.1 Gene:KLHL12 / 59349 HGNCID:19360 Length:623 Species:Homo sapiens


Alignment Length:618 Identity:201/618 - (32%)
Similarity:297/618 - (48%) Gaps:70/618 - (11%)


- Green bases have known domain annotations that are detailed below.


  Fly    46 SGATAASHRTN--LPSYC------------NAQYPFKVLSNLNQLREQSRFCDVEIIAGMATLSA 96
            |||...:.||:  |..:|            ...:...:|:::|.||:.:..|||.:........|
Human    37 SGAQLQNPRTHFVLSPHCFMGGIMAPKDIMTNTHAKSILNSMNSLRKSNTLCDVTLRVEQKDFPA 101

  Fly    97 HRAVLSAASAYFEAMFRPELGLNEVKQKSVVLHTIDGDILHILLDFIYTGRCEITQSNVQELLAA 161
            ||.||:|.|.||.|||..|  |:|..:..|.:..:....:.|||||:||....:|..||||||.|
Human   102 HRIVLAACSDYFCAMFTSE--LSEKGKPYVDIQGLTASTMEILLDFVYTETVHVTVENVQELLPA 164

  Fly   162 ADMLQLNEVVDGCCEFLCRELHASNALGILRFAEAHNCESLAKSALNFVHANFPAVTLEDEFLET 226
            |.:|||..|...|||||..:|..||.|||..|||.|||..|.::|..|...:||.|...:||:..
Human   165 ACLLQLKGVKQACCEFLESQLDPSNCLGIRDFAETHNCVDLMQAAEVFSQKHFPEVVQHEEFILL 229

  Fly   227 PQTLLSQLLNSELLRVDSESQVFQAALRWIKHDVTQRRCYVFDVLSHVRMALVPVKVIDKALKDD 291
            .|..:.:|:..:.::||||..||:|.:.|:||...:|...:.::|.:|||.|:..:.|     .|
Human   230 SQGEVEKLIKCDEIQVDSEEPVFEAVINWVKHAKKEREESLPNLLQYVRMPLLTPRYI-----TD 289

  Fly   292 CRDMSVKIALRSICRDIASK----------RGQLVPLRVCPRQLAKKNIYIIGGSHRDTPRTWNS 346
            ..|....|.....|||:..:          |.|:...|...|..|.:.:.::||        :.|
Human   290 VIDAEPFIRCSLQCRDLVDEAKKFHLRPELRSQMQGPRTRARLGANEVLLVVGG--------FGS 346

  Fly   347 ADCIFETVAKFDIFRREWTETAPMEVGRILPGVS---------ALNGKIYVVGGERGSQILANGE 402
            .....:.|.|:|...:||:         .||.::         :|:.:|||:||..|...|::.|
Human   347 QQSPIDVVEKYDPKTQEWS---------FLPSITRKRRYVASVSLHDRIYVIGGYDGRSRLSSVE 402

  Fly   403 VYD---PQNDVWQPIAPMIVPRCEFGLCTMGGNLFAVGGWIGDDIGGSMECYDPEQDLWKLMGSM 464
            ..|   .::.||..:|||.|.|...|..|:|..::..||:.|.....|||.|||..|.|.::|.|
Human   403 CLDYTADEDGVWYSVAPMNVRRGLAGATTLGDMIYVSGGFDGSRRHTSMERYDPNIDQWSMLGDM 467

  Fly   465 PQPRFSMGVVSFEGLIYIVGGCTTTTRHLPDLISFNPVTKEWNELARMQTARCQMGVAVLDRYLY 529
            ...|...|:|...|:||.:|| ......|..:..::|.|..|..:..|.|.|...|||:|:.::|
Human   468 QTAREGAGLVVASGVIYCLGG-YDGLNILNSVEKYDPHTGHWTNVTPMATKRSGAGVALLNDHIY 531

  Fly   530 VVGGSSISQDILSSVERYSFDEDKWTTVCALNVPRAIPAVVAADGLLYVAGGDQPCEVNFYRAQV 594
            ||||...:.. |||||.|:...|.||||.::..||.........|.||...|        |....
Human   532 VVGGFDGTAH-LSSVEAYNIRTDSWTTVTSMTTPRCYVGATVLRGRLYAIAG--------YDGNS 587

  Fly   595 TINAVECYDPLSDTWKNCPDLPVSRSEAGAVVV 627
            .::::|||||:.|:|:....:...|.:||..|:
Human   588 LLSSIECYDPIIDSWEVVTSMGTQRCDAGVCVL 620

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG9426NP_609616.1 BTB 73..179 CDD:279045 46/105 (44%)
PHA03098 78..558 CDD:222983 171/501 (34%)
BACK 187..289 CDD:285009 36/101 (36%)
Kelch 330..384 CDD:128874 11/62 (18%)
KELCH repeat 374..417 CDD:276965 15/54 (28%)
Kelch 385..431 CDD:128874 18/48 (38%)
KELCH repeat 421..465 CDD:276965 16/43 (37%)
Kelch <447..478 CDD:128874 13/30 (43%)
Kelch_6 467..516 CDD:290672 14/48 (29%)
KELCH repeat 468..512 CDD:276965 12/43 (28%)
Kelch_1 515..557 CDD:279660 19/41 (46%)
KELCH repeat 516..561 CDD:276965 21/44 (48%)
KELCH repeat 564..617 CDD:276965 13/52 (25%)
Kelch 575..627 CDD:128874 14/51 (27%)
KLHL12XP_011508137.1 BTB 78..181 CDD:279045 45/104 (43%)
PHA03098 101..556 CDD:222983 165/480 (34%)
BACK 190..291 CDD:285009 37/105 (35%)
KELCH repeat 329..370 CDD:276965 12/57 (21%)
Kelch 337..384 CDD:128874 11/63 (17%)
KELCH repeat 374..420 CDD:276965 13/45 (29%)
Kelch 385..434 CDD:128874 18/48 (38%)
KELCH repeat 424..467 CDD:276965 16/42 (38%)
Kelch 436..481 CDD:128874 16/44 (36%)
KELCH repeat 471..514 CDD:276965 12/43 (28%)
Kelch 482..528 CDD:128874 15/46 (33%)
KELCH repeat 518..562 CDD:276965 21/44 (48%)
Kelch 529..575 CDD:128874 18/46 (39%)
KELCH repeat 565..610 CDD:276965 13/52 (25%)
Kelch 576..620 CDD:128874 14/51 (27%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG4441
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D312716at33208
OrthoFinder 1 1.000 - - FOG0000036
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X9
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
54.820

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