DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG9426 and KLHL1

DIOPT Version :9

Sequence 1:	NP_609616.1	Gene:	CG9426 / 34719	FlyBaseID:	FBgn0032485	Length:	627	Species:	Drosophila melanogaster
Sequence 2:	NP_065917.1	Gene:	KLHL1 / 57626	HGNCID:	6352	Length:	748	Species:	Homo sapiens

Alignment Length:	624	Identity:	197/624 - (31%)
Similarity:	306/624 - (49%)	Gaps:	57/624 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 NPTGGGGDGDFFGQNLGSGATAASHRTNLPS------YCNAQYPFKVLSNLNQLREQSRFCDVEI 87
            |.:...|:|  .|..|.|...:.:.:::|.|      |....:..:....:....:|.:.|||.:
Human   154 NSSQATGEG--CGHRLSSTGHSMTPQSDLDSSSSEEFYQAVHHAEQTFRKMESYLKQQQLCDVIL 216

  Fly    88 IAGMATLSAHRAVLSAASAYFEAMFRPELGLNEVKQKSVVLHTIDGDILHILLDFIYTGRCEITQ 152
            |.|...:.|||.|||:.|.||.|||..:  :.|.||:.:.:..||.:.|..|:.|.|||..|:.:
Human   217 IVGNRKIPAHRLVLSSVSDYFAAMFTSD--VCEAKQEEIKMEGIDPNALWDLVQFAYTGCLELKE 279

  Fly   153 SNVQELLAAADMLQLNEVVDGCCEFLCRELHASNALGILRFAEAHNCESLAKSALNFVHANFPAV 217
            ..::.|||||.:|||.:||:.||.||.:.||.||.|||..||:|..|..|.|.|.::...|...|
Human   280 DTIENLLAAACLLQLPQVVEVCCHFLMKLLHPSNCLGIRAFADAQGCIELMKVAHSYTMENIMEV 344

  Fly   218 TLEDEFLETPQTLLSQLLNSELLRVDSESQVFQAALRWIKHDVTQRRCYVFD-VLSHVRMALVPV 281
            ....|||..|...|.:||.|:.:.|..|..:|.|.:.|:|:|: |.||.... :|:.:|:.|:|.
Human   345 IRNQEFLLLPAEELHKLLASDDVNVPDEETIFHALMMWVKYDM-QSRCNDLSMLLAFIRLPLLPP 408

  Fly   282 KVI----DKAL-KDD--CRDMSVKIALRSICRDIASKRGQLVPL-RVCPRQLAKKNIYIIGGSHR 338
            :::    :.|| |:|  |:    |:.|.::...:..:|..|:.. |..||:.....:|.:||...
Human   409 QILADLENHALFKNDLECQ----KLILEAMKYHLLPERRTLMQSPRTKPRKSTVGTLYAVGGMDN 469

  Fly   339 DTPRTWNSADCIFETVAKFDIFRREWTETAPMEVGRILPGVSALNGKIYVVGGERGSQILANGEV 403
            :...|         |:.|:|:....|.:...|...|:..||:.::.|::|:||..|.:.|...|.
Human   470 NKGAT---------TIEKYDLRTNLWIQAGMMNGRRLQFGVAVIDDKLFVIGGRDGLKTLNTVEC 525

  Fly   404 YDPQNDVWQPIAPMIVPRCEFGLCTMGGNLFAVGGWIGDDIGGSMECYDPEQDLWKLMGSMPQPR 468
            |:|:...|..:.||...|...|:..:.|.::||||..|.....::|.:||:...|..:.||...|
Human   526 YNPKTKTWTVLPPMSTHRHGLGVTVLEGPIYAVGGHDGWSYLNTVERWDPQSQQWTFVASMSIAR 590

  Fly   469 FSMGVVSFEGLIYIVGG-----CTTTTRHLPDLISFNPVTKEWNELARMQTARCQMGVAVLDRYL 528
            .::||.:..|.:|.|||     |.::..:      ::|.|.:||..|.|...|..:|||..|.:|
Human   591 STVGVAALNGKLYSVGGRDGSSCLSSMEY------YDPHTNKWNMCAPMCKRRGGVGVATCDGFL 649

  Fly   529 YVVGG-----SSISQDILSSVERYSFDEDKWTTVCALNVPRAIPAVVAADGLLYVAGGDQPCEVN 588
            |.|||     |:....:|..||||....|.||.|..|::||....|......||..||
Human   650 YAVGGHDAPASNHCSRLLDYVERYDPKTDTWTMVAPLSMPRDAVGVCLLGDRLYAVGG------- 707

  Fly   589 FYRAQVTINAVECYDPLSDTWKNCPDLPVSRSEAGAVVV 627
             |..|..:|.:|.|||.::.|.....|.:.|:.|..||:
Human   708 -YDGQTYLNTMESYDPQTNEWTQMASLNIGRAGACVVVI 745

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9426	NP_609616.1	BTB	73..179	CDD:279045	43/105 (41%)
		PHA03098	78..558	CDD:222983	166/498 (33%)
		BACK	187..289	CDD:285009	36/107 (34%)
		Kelch	330..384	CDD:128874	12/53 (23%)
		KELCH repeat	374..417	CDD:276965	13/42 (31%)
		Kelch	385..431	CDD:128874	14/45 (31%)
		KELCH repeat	421..465	CDD:276965	13/43 (30%)
		Kelch	<447..478	CDD:128874	9/30 (30%)
		Kelch_6	467..516	CDD:290672	15/53 (28%)
		KELCH repeat	468..512	CDD:276965	14/48 (29%)
		Kelch_1	515..557	CDD:279660	19/46 (41%)
		KELCH repeat	516..561	CDD:276965	20/49 (41%)
		KELCH repeat	564..617	CDD:276965	15/52 (29%)
		Kelch	575..627	CDD:128874	16/51 (31%)
KLHL1	NP_065917.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	22..93
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	151..182		7/29 (24%)
		PHA03098	206..728	CDD:222983	182/551 (33%)
		Kelch 1	460..506		12/54 (22%)
		KELCH repeat	496..539	CDD:276965	13/42 (31%)
		Kelch 2	507..553		14/45 (31%)
		KELCH repeat	543..587	CDD:276965	13/43 (30%)
		Kelch 3	555..600		14/44 (32%)
		KELCH repeat	590..633	CDD:276965	14/48 (29%)
		Kelch 4	601..647		15/51 (29%)
		KELCH repeat	637..687	CDD:276965	20/49 (41%)
		Kelch 5	649..700		19/50 (38%)
		KELCH repeat	690..734	CDD:276965	14/51 (27%)
		Kelch 6	701..747		17/53 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4441
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D312716at33208
OrthoFinder	1	1.000	-	-		FOG0000036
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X9
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.820