DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG9426 and KLHL8

DIOPT Version :9

Sequence 1:	NP_609616.1	Gene:	CG9426 / 34719	FlyBaseID:	FBgn0032485	Length:	627	Species:	Drosophila melanogaster
Sequence 2:	NP_001278932.1	Gene:	KLHL8 / 57563	HGNCID:	18644	Length:	620	Species:	Homo sapiens

Alignment Length:	568	Identity:	172/568 - (30%)
Similarity:	267/568 - (47%)	Gaps:	38/568 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    72 NLNQLREQSRFCDVEIIAGMATLSAHRAVLSAASAYFEAMFRPELGLNEVKQKSVVLHTIDGDIL 136
            :|.:..|....|||.:..|...:|.|:.||:....||.|||..|:.  |.||..:.:...|||.:
Human    56 SLLRFYENGELCDVTLKVGSKLISCHKLVLACVIPYFRAMFLSEMA--EAKQTLIEIRDFDGDAI 118

  Fly   137 HILLDFIYTGRCEITQSNVQELLAAADMLQLNEVVDGCCEFLCRELHASNALGILRFAEAHNCES 201
            ..|:.|:|:.|..:|..|||.||.||.:||:..|...|||::....|.||.|.:..|||:||...
Human   119 EDLVKFVYSSRLTLTVDNVQPLLYAACILQVELVARACCEYMKLHFHPSNCLAVRAFAESHNRID 183

  Fly   202 LAKSALNFVHANFPAVTLEDEFLETPQTLLSQLLNSELLRVDSESQVFQAALRWIKHDVTQRRCY 266
            |...|..:...:|..|...::|:......|.:||:|..|.:::|.||:.||::|:..:......:
Human   184 LMDMADQYACDHFTEVVECEDFVSVSPQHLHKLLSSSDLNIENEKQVYNAAIKWLLANPQHHSKW 248

  Fly   267 VFDVLSHVRMALVPVKVIDKALKDDCRDMSVKIALRSICRDIASK--------RGQLVP-----L 318
            :.:.|:.||:.|:||   |..:....::..||..|:  |||:..:        ..:.||     :
Human   249 LDETLAQVRLPLLPV---DFLMGVVAKEQIVKQNLK--CRDLLDEARNYHLHLSSRAVPDFEYSI 308

  Fly   319 RVCPRQLAKKNIYIIGGSHRDTPRTWNSADCIFETVAKFDIFRREWTETAPMEVGRILPGVSALN 383
            |..||:.....::.:||       ...|.| .|.::..:.|.:..|.....|...|...||.::.
Human   309 RTTPRKHTAGVLFCVGG-------RGGSGD-PFRSIECYSINKNSWFFGPEMNSRRRHVGVISVE 365

  Fly   384 GKIYVVGGERGSQILANGEVYDPQNDVWQPIAPMIVPRCEFGLCTMGGNLFAVGGWIGDDIGGSM 448
            ||:|.|||..|::.|.:.|::||..:.|...|.|...|....|.::||.::|:||...:.....:
Human   366 GKVYAVGGHDGNEHLGSMEMFDPLTNKWMMKASMNTKRRGIALASLGGPIYAIGGLDDNTCFNDV 430

  Fly   449 ECYDPEQDLWKLMGSMPQPRFSMGVVSFEGLIYIVGGCTTTTRHLPDLISFNPVTKEWNELARMQ 513
            |.||.|.|.|..:..|..||..:|.|:....:|.||| ......|..:..::|...:|.|:..|.
Human   431 ERYDIESDQWSTVAPMNTPRGGVGSVALVNHVYAVGG-NDGMASLSSVERYDPHLDKWIEVKEMG 494

  Fly   514 TARCQMGVAVLDRYLYVVGGSSISQDILSSVERYSFDEDKWTTVCALNVPRAIPAVVAADGLLYV 578
            ..|...||:.|...||||||.. ....|||||||....:||..|.||..||....:....|.::.
Human   495 QRRAGNGVSKLHGCLYVVGGFD-DNSPLSSVERYDPRSNKWDYVAALTTPRGGVGIATVMGKIFA 558

  Fly   579 AGGDQPCEVNFYRAQVTINAVECYDPLSDTWKNCPDLPVSRSEAGAVV 626
            .||        :.....:|.||.:||:.:.|:....:...|:.||..|
Human   559 VGG--------HNGNAYLNTVEAFDPVLNRWELVGSVSHCRAGAGVAV 598

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9426	NP_609616.1	BTB	73..179	CDD:279045	40/105 (38%)
		PHA03098	78..558	CDD:222983	153/492 (31%)
		BACK	187..289	CDD:285009	29/101 (29%)
		Kelch	330..384	CDD:128874	11/53 (21%)
		KELCH repeat	374..417	CDD:276965	16/42 (38%)
		Kelch	385..431	CDD:128874	15/45 (33%)
		KELCH repeat	421..465	CDD:276965	13/43 (30%)
		Kelch	<447..478	CDD:128874	11/30 (37%)
		Kelch_6	467..516	CDD:290672	13/48 (27%)
		KELCH repeat	468..512	CDD:276965	11/43 (26%)
		Kelch_1	515..557	CDD:279660	19/41 (46%)
		KELCH repeat	516..561	CDD:276965	21/44 (48%)
		KELCH repeat	564..617	CDD:276965	10/52 (19%)
		Kelch	575..627	CDD:128874	12/52 (23%)
KLHL8	NP_001278932.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..35
		BTB	57..161	CDD:279045	40/105 (38%)
		PHA03098	60..535	CDD:222983	152/491 (31%)
		BACK	169..271	CDD:285009	29/104 (28%)
		Kelch	319..366	CDD:128874	11/54 (20%)
		Kelch 1	319..366		11/54 (20%)
		KELCH repeat	356..399	CDD:276965	16/42 (38%)
		Kelch	367..413	CDD:128874	15/45 (33%)
		Kelch 2	367..413		15/45 (33%)
		KELCH repeat	403..447	CDD:276965	13/43 (30%)
		Kelch 3	415..460		14/44 (32%)
		Kelch	415..458	CDD:128874	14/42 (33%)
		KELCH repeat	450..495	CDD:276965	12/45 (27%)
		Kelch	461..502	CDD:128874	10/41 (24%)
		Kelch 4	462..507		13/45 (29%)
		KELCH repeat	497..542	CDD:276965	22/45 (49%)
		Kelch	508..554	CDD:128874	20/46 (43%)
		Kelch 5	508..554		20/46 (43%)
		KELCH repeat	544..586	CDD:276965	10/49 (20%)
		Kelch	555..599	CDD:128874	12/52 (23%)
		Kelch 6	556..601		12/51 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4441
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D312716at33208
OrthoFinder	1	1.000	-	-		FOG0000036
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.820