DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG9426 and KLHL28

DIOPT Version :9

Sequence 1:NP_609616.1 Gene:CG9426 / 34719 FlyBaseID:FBgn0032485 Length:627 Species:Drosophila melanogaster
Sequence 2:NP_001295041.1 Gene:KLHL28 / 54813 HGNCID:19741 Length:585 Species:Homo sapiens


Alignment Length:603 Identity:176/603 - (29%)
Similarity:274/603 - (45%) Gaps:113/603 - (18%)


- Green bases have known domain annotations that are detailed below.


  Fly    58 PSYCNAQ----YPFKVLSNLNQLREQSRFCDVEIIAGMATLSAHRAVLSAASAYFEAMFRPELGL 118
            |:|..|.    :..::|..||.||:....||:.:..|...:.||:.||::.|.||:|||..  .|
Human    20 PTYMLANLTHLHSEQLLQGLNLLRQHHELCDIILRVGDVKIHAHKVVLASVSPYFKAMFTG--NL 82

  Fly   119 NEVKQKSVVLHTIDGDILHILLDFIYTGRCEITQSNVQELLAAADMLQLNEVVDGCCEFLCRELH 183
            :|.:...|....||...|..::::.|||...|:|..|:.||.||::||:..|:..||.||..:|.
Human    83 SEKENSEVEFQCIDETALQAIVEYAYTGTVFISQDTVESLLPAANLLQIKLVLKECCAFLESQLD 147

  Fly   184 ASNALGILRFAEAHNCESLAKSALNFVHANFPAVTLEDEFLETPQTLLSQLLNSELLRVDSESQV 248
            ..|.:||.||||.:.|..|..:|..::..||.||...:||.|.....|.::::::.|.|.:|..|
Human   148 PGNCIGISRFAETYGCRDLYLAATKYICQNFEAVCQTEEFFELTHADLDEIVSNDCLNVATEETV 212

  Fly   249 FQAALRWIKHDVTQRRCYVFDVLSHVRMALVPVKVIDK------ALKDD--CRDM---------- 295
            |.|...|||:||.:|:.|:..:|:.||:.|:.||.:.:      .::||  |:.:          
Human   213 FYALESWIKYDVQERQKYLAQLLNSVRLPLLSVKFLTRLYEANHLIRDDRTCKHLLNEALKYHFM 277

  Fly   296 -------------SVKIALRSICRDIASKRG-------------------QLVPLRVCPRQ---- 324
                         ..:.|.:.:|. :..|.|                   .|.||.: ||.    
Human   278 PEHRLSHQTVLMTRPRCAPKVLCA-VGGKSGLFACLDSVEMYFPQNDSWIGLAPLNI-PRYEFGI 340

  Fly   325 -LAKKNIYIIGG------------SHRDTPRTWNSADCIFETVAKFDIFRREWTETAPMEVGRIL 376
             :..:.:|:|||            .|.::...||.     :|        ..||....|...|..
Human   341 CVLDQKVYVIGGIATNVRPGVTIRKHENSVECWNP-----DT--------NTWTSLERMNESRST 392

  Fly   377 PGVSALNGKIYVVGGERGSQILANGEVYDPQNDVWQPIAPMIVPRCEFGLCTMGGNLFAVGGWIG 441
            .||..|.|::|.:||..|...|.:.|.|.|:...|||:|||...|..|....:.|.::|:||: |
Human   393 LGVVVLAGELYALGGYDGQSYLQSVEKYIPKIRKWQPVAPMTTTRSCFAAAVLDGMIYAIGGY-G 456

  Fly   442 DDIGGSMECYDPEQDLWKLMGSMPQPRFSMGVVSFEGLIYIVGGCTTTTRHLPDLISFNPVTKEW 506
            .....|:|.|||.:|.|:::.||...|...||....|.|::|||....: ||..:..::|...:|
Human   457 PAHMNSVERYDPSKDSWEMVASMADKRIHFGVGVMLGFIFVVGGHNGVS-HLSSIERYDPHQNQW 520

  Fly   507 NELARMQTARCQMGVAVLDRYLYVVGGSSISQDILSSVERYSFDEDKWTTVCALNVPRAIPAVVA 571
            .....|:..|..:|.||:|.|||||||.| ....|::|::|....|.|               :.
Human   521 TVCRPMKEPRTGVGAAVIDNYLYVVGGHS-GSSYLNTVQKYDPISDTW---------------LD 569

  Fly   572 ADGLLYVAGGDQPCEVNF 589
            :.|::|       |..||
Human   570 SAGMIY-------CRCNF 580

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG9426NP_609616.1 BTB 73..179 CDD:279045 39/105 (37%)
PHA03098 78..558 CDD:222983 163/546 (30%)
BACK 187..289 CDD:285009 36/107 (34%)
Kelch 330..384 CDD:128874 15/65 (23%)
KELCH repeat 374..417 CDD:276965 17/42 (40%)
Kelch 385..431 CDD:128874 16/45 (36%)
KELCH repeat 421..465 CDD:276965 15/43 (35%)
Kelch <447..478 CDD:128874 12/30 (40%)
Kelch_6 467..516 CDD:290672 13/48 (27%)
KELCH repeat 468..512 CDD:276965 12/43 (28%)
Kelch_1 515..557 CDD:279660 18/41 (44%)
KELCH repeat 516..561 CDD:276965 18/44 (41%)
KELCH repeat 564..617 CDD:276965 5/26 (19%)
Kelch 575..627 CDD:128874 4/15 (27%)
KLHL28NP_001295041.1 PHA03098 49..567 CDD:222983 162/537 (30%)
KELCH repeat 335..386 CDD:276965 11/63 (17%)
KELCH repeat 390..433 CDD:276965 17/42 (40%)
KELCH repeat 437..479 CDD:276965 14/42 (33%)
KELCH repeat 483..527 CDD:276965 12/44 (27%)
KELCH repeat 530..573 CDD:276965 18/58 (31%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG4441
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D312716at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X9
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
54.820

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