DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG9426 and dbo

DIOPT Version :9

Sequence 1:	NP_609616.1	Gene:	CG9426 / 34719	FlyBaseID:	FBgn0032485	Length:	627	Species:	Drosophila melanogaster
Sequence 2:	NP_524989.2	Gene:	dbo / 53556	FlyBaseID:	FBgn0040230	Length:	623	Species:	Drosophila melanogaster

Alignment Length:	635	Identity:	210/635 - (33%)
Similarity:	310/635 - (48%)	Gaps:	58/635 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 NGNTS-PNANANQNANQNPTGGGGDGDFFGQNLGSGATAASHRTNLPSYCNAQYPFKVLSNLNQL 76
            :|:|: |...|......|.|.||      |.::||.|..........|:.:.::|...|:.||.|
  Fly     7 SGSTAQPRDAAVTGTGGNSTAGG------GSSVGSTAVDRPPSPARLSHTSEKHPKVTLTELNML 65

  Fly    77 REQSRFCDVEIIAGMATLSAHRAVLSAASAYFEAMFRPELGLNEVKQKSVVLHTIDGDILHILLD 141
            |.....|||.:..|...:.|||.:|||.|:||.|||..|  |.|.:|..|.:..||.:.:.:|:|
  Fly    66 RRHRELCDVVLNVGGRKIFAHRVILSACSSYFCAMFTGE--LEESRQTEVTIRDIDENAMELLID 128

  Fly   142 FIYTGRCEITQSNVQELLAAADMLQLNEVVDGCCEFLCRELHASNALGILRFAEAHNCESLAKSA 206
            |.||....:.:||||.||.||.:|||.|:.|.|||||.|:|..:|.|||..||:.|:|..|.:.|
  Fly   129 FCYTAHIIVEESNVQTLLPAACLLQLVEIQDICCEFLKRQLDPTNCLGIRAFADTHSCRELLRIA 193

  Fly   207 LNFVHANFPAVTLEDEFLETPQTLLSQLLNSELLRVDSESQVFQAALRWIKHDVTQRRCYVFDVL 271
            ..|...||..|...:|||..|...|..::.|:.|.|.||.|||.|.:.|:|::|.:||.::..||
  Fly   194 DKFTQHNFQEVMESEEFLLLPVGQLVDIICSDELNVRSEEQVFNAVMSWLKYNVAERRQHLAQVL 258

  Fly   272 SHVRMALVPVKVIDKALKDDCRDMSVKIALRS--ICRDIA--SKRGQLVPL--------RVCPRQ 324
            .|||:.|:..|.:...:..|       :.:||  .|||:.  :|...|:|.        |..||:
  Fly   259 QHVRLPLLSPKFLVGTVGSD-------LLVRSDEACRDLVDEAKNYLLLPQERPLMQGPRTRPRK 316

  Fly   325 LAKKN--IYIIGGSHRDTPRTWNSADCIFETVAKFDIFRREWTETAPMEVGRILPGVSALNGKIY 387
            ..::.  ::.:||        |.|.|.| .:|.:||....:|...|||...|...||:.||..:|
  Fly   317 PTRRGEVLFAVGG--------WCSGDAI-ASVERFDPQTNDWKMVAPMSKRRCGVGVAVLNDLLY 372

  Fly   388 VVGGERGSQILANGEVYDPQNDVWQ-PIAPMIVPRCEFGLCTMGGNLFAVGGWIGDDIGGSMECY 451
            .|||..|...|.:.|.||||.:.|. .:||....|...|:..:.|.|:||||..|......:|.|
  Fly   373 AVGGHDGQSYLNSIERYDPQTNQWSCDVAPTTSCRTSVGVAVLDGFLYAVGGQDGVQCLNHVERY 437

  Fly   452 DPEQDLWKLMGSMPQPRFSMGVVSFEGLIYIVGG----CTTTTRHLPDLISFNPVTKEWNELARM 512
            ||:::.|..:..|...|..:.|....|.:|.:||    |...|     :..::|...:|..::.|
  Fly   438 DPKENKWSKVAPMTTRRLGVAVAVLGGFLYAIGGSDGQCPLNT-----VERYDPRHNKWVAVSPM 497

  Fly   513 QTARCQMGVAVLDRYLYVVGGSSISQDILSSVERYSFDEDKWTTVCALNVPRAIPAVVAADGLLY 577
            .|.|..:|.||.:.|:|.|||.....: |||.|||:...:.|:.:.|:...|:...:...:|.||
  Fly   498 STRRKHLGCAVFNNYIYAVGGRDDCME-LSSAERYNPLTNTWSPIVAMTSRRSGVGLAVVNGQLY 561

  Fly   578 VAGGDQPCEVNFYRAQVTINAVECYDPLSDTWKNCPDLPVSRSEAGAVVV 627
            ..||        :.....:..:|.|||.::.|:.|..:...|...|..|:
  Fly   562 AVGG--------FDGSAYLKTIEVYDPETNQWRLCGCMNYRRLGGGVGVM 603

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9426	NP_609616.1	BTB	73..179	CDD:279045	49/105 (47%)
		PHA03098	78..558	CDD:222983	175/498 (35%)
		BACK	187..289	CDD:285009	39/101 (39%)
		Kelch	330..384	CDD:128874	17/53 (32%)
		KELCH repeat	374..417	CDD:276965	18/43 (42%)
		Kelch	385..431	CDD:128874	16/46 (35%)
		KELCH repeat	421..465	CDD:276965	14/43 (33%)
		Kelch	<447..478	CDD:128874	8/30 (27%)
		Kelch_6	467..516	CDD:290672	12/52 (23%)
		KELCH repeat	468..512	CDD:276965	10/47 (21%)
		Kelch_1	515..557	CDD:279660	16/41 (39%)
		KELCH repeat	516..561	CDD:276965	17/44 (39%)
		KELCH repeat	564..617	CDD:276965	12/52 (23%)
		Kelch	575..627	CDD:128874	12/51 (24%)
dbo	NP_524989.2	BTB_POZ_KLHL20_KLEIP	49..176	CDD:349558	55/128 (43%)
		PHA03098	69..587	CDD:222983	187/549 (34%)
		KELCH repeat	359..403	CDD:276965	18/43 (42%)
		KELCH repeat	407..451	CDD:276965	14/43 (33%)
		KELCH repeat	454..497	CDD:276965	10/47 (21%)
		KELCH repeat	501..545	CDD:276965	17/44 (39%)
		KELCH repeat	548..593	CDD:276965	12/52 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45464355
Domainoid	1	1.000	52	1.000	Domainoid score	I4252
eggNOG	1	0.900	-	-		E1_KOG4441
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	57	1.000	Inparanoid score	I2576
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D312716at33208
OrthoFinder	1	1.000	-	-		FOG0000036
OrthoInspector	1	1.000	-	-		otm2846
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24412
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X9
	10	9.900